関: sulfamethopyrazine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/02 14:49:43」(JST)

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Sulfalene (INN, USAN) or sulfametopyrazine (BAN) is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.^[2]^[3] There are only two countries in which it is currently still marketed: Thailand and Ireland.^[3]

References

^ ^a ^b ^c ^d "Sulfalene". MIMS Drug Information System. Retrieved 26 August 2011.
^ DrugBank DB00664
^ ^a ^b Brayfield, A, ed. (9 May 2013). "Sulfametopyrazine". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 28 March 2014.

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English Journal

An open randomized clinical trial in comparing two artesunate-based combination treatments on Plasmodium falciparum malaria in Nigerian children: artesunate/sulphamethoxypyrazine/pyrimethamine (fixed dose over 24 hours) versus artesunate/amodiaquine (fixed dose over 48 hours).

Ayede IA, Falade AG, Sowunmi A, Jansen FH.SourceDepartment of Paediatrics, College of Medicine, University College Hospital, Ibadan, Nigeria. idayede@yahoo.co.uk
Malaria journal.Malar J.2010 Dec 31;9:378.
BACKGROUND: Several studies have demonstrated the efficacy of artemisinin-combination therapy (ACT) across malaria zones of the world. Fixed dose ACT with shorter courses and fewer tablets may be key determinants to ease of administration and compliance.METHODS: Children aged one year to 13 years pr
PMID 21194422

Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance.

Okafor HU, Shu EN, Oguonu T.SourceDepartment of Paediatrics, College of Medicine, University of Nigeria, Enugu, Nigeria. huche57@yahoo.com
Journal of tropical pediatrics.J Trop Pediatr.2010 Dec;56(6):398-406. Epub 2010 Feb 8.
Combination therapy with artemesinin or non-artemesinin-based antimalarials (ACTs or NACTs) are known to retard the development and progression of drug resistance in Plasmodium falciparum (P. falciparum). The optimal antimalarial combinations in Africa are yet unknown. We evaluate the therapeutic ef
PMID 20144932

Japanese Journal

Sulfalene concentrations in plasma and blood cells of Plasmodium falciparum malaria cases after treatment with metakelfin using high-performance liquid chromatography

DUA Virendra K.,SARIN Reema,GUPTA N. C.,SHARMA V. P.
Journal of chromatography. B, Biomedical sciences and applications 714(2), 390-394, 1998-09-04
NAID 10024531270

Sulfamethoxypyrazine(Sulfalene)に関する研究

北本治 [他]
日本化学療法学会雑誌 16(6), 765-769, 1968-09
NAID 40017449538

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★リンクテーブル★

リンク元	「スルファレン」「sulfamethopyrazine」

「スルファレン」

Systematic (IUPAC) name
	4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
Clinical data
Trade names	Eadazine, Kelfizina, Kelfizine W, Longum
AHFS/Drugs.com	International Drug Names
Legal status	?
Routes	Oral
Pharmacokinetic data
Protein binding	60 to 80%
Half-life	60 to 65 hours
Excretion	Urinary
Identifiers
CAS number	152-47-6
ATC code	J01ED02 QJ01EQ19
PubChem	CID 9047
DrugBank	DB00664
ChemSpider	8695
UNII	T6BL4ZC15G
KEGG	D01216
Synonyms	Sulfametopyrazine
Chemical data
Formula	C11H12N4O3S
Mol. mass	280.304 g/mol
	SMILES O=S(=O)(Nc1nccnc1OC)c2ccc(N)cc2;
	InChI InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) ; Key:KXRZBTAEDBELFD-UHFFFAOYSA-N ;
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