Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/24 13:36:02」(JST)

wiki en

Sucrase is the name given to a number of enzymes that catalyze the hydrolysis of sucrose to fructose and glucose. The enzyme invertase, which occurs more commonly in plants, also hydrolyzes sucrose but by a different mechanism.^[1]

Types

EC 3.2.1.10 is sucrase-isomaltase
EC 3.2.1.26 is invertase
EC 3.2.1.48 is sucrose alpha-glucosidase

Physiology

Sucrose intolerance (also known as Congenital Sucrase-Isomaltase Deficiency (CSID) or Sucrase-isomaltase deficiency) occurs when sucrase is not secreted in the small intestine. With sucrose intolerance, the result of consuming sucrose is excess gas production and often diarrhea and malabsorption. Lactose intolerance is a related disorder that reflects an individual's inability to hydrolyze the disaccharide lactose.

Sucrase is secreted by the tips of the villi of the epithelium in the small intestine. Its levels are reduced in response to villi-blunting events such as celiac sprue and the inflammation associated with the disorder. The levels increase in Pregnancy/Lactation and Diabetes as the villi hypertrophy.

Use in chemical analysis

Sucrose itself is a non-reducing sugar and therefore will not test positive with Benedict's solution. In order to test for sucrose, the sample is treated with sucrase. The sucrose is hydrolysed into glucose and fructose, with glucose being a reducing sugar, which in turn tests positive with Benedict's solution^{[citation needed]}.

References

^ Hubert Schiweck, Margaret Clarke, Günter Pollach "Sugar” in Ullmann’s Encyclopedia of Industrial Chemistry 2007, Wiley-VCH, Weinheim. doi:10.1002/14356007.a25_345.pub2

External links

Sucrase at the US National Library of Medicine Medical Subject Headings (MeSH)
Diagnosis of sucrase deficiency

This hydrolase article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 栄養の吸収および吸収不良の機序 mechanisms of nutrient absorption and malabsorption
2. 小児における慢性下痢の原因の概要 overview of the causes of chronic diarrhea in children
3. 小児における腎結石症の疫学および危険因子 epidemiology of and risk factors for nephrolithiasis in children
4. ロタウイルス感染の臨床症状および診断 clinical manifestations and diagnosis of rotavirus infection
5. 熱帯性スプルー tropical sprue

English Journal

Effects of medium-chain triglycerides on intestinal morphology and energy metabolism of intrauterine growth retarded weanling piglets.

Zhang LL1, Zhang H1, Li Y1, Wang T1.
Archives of animal nutrition.Arch Anim Nutr.2017 Jun;71(3):231-245. doi: 10.1080/1745039X.2017.1312812.
PMID 28429991

Phenolic compounds increase the transcription of mouse intestinal maltase-glucoamylase and sucrase-isomaltase.

Simsek M1, Quezada-Calvillo R, Nichols BL, Hamaker BR.
Food & function.Food Funct.2017 May 24;8(5):1915-1924. doi: 10.1039/c7fo00015d.
PMID 28443839

A potential anti-tumor effect of leukotriene C4 through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells.

Mehdawi LM1, Satapathy SR1, Gustafsson A2, Lundholm K2, Alvarado-Kristensson M3, Sjölander A1.
Oncotarget.Oncotarget.2017 May 23;8(21):35033-35047. doi: 10.18632/oncotarget.16591.
PMID 28402256

Japanese Journal

血糖値上昇抑制効果を有する機能性糖質L-アラビノースの生理機能研究と工業生産技術の開発

柴沼清,出川洋子,宮脇洋之,世利謙二,讃井和子
応用糖質科学 : 日本応用糖質科学会誌 = Bulletin of applied glycoscience 1(1), 65-69, 2011-01-20
NAID 10027412282

Jejunal Induction of SI and SGLT1 Genes in Rats by High-Starch/Low-Fat Diet Is Associated with Histone Acetylation and Binding of GCN5 on the Genes

INOUE Seiya,MOCHIZUKI Kazuki,GODA Toshinao
Journal of Nutritional Science and Vitaminology 57(2), 162-169, 2011
… The intestinal expression of genes involved in carbohydrate digestion and absorption, such as sucrase-isomaltase (SI) and sodium-dependent glucose cotransporter (SGLT1), is higher in rodents fed a high-starch/low-fat (HS) diet than in those fed a low-starch/high-fat (LS) diet. …
NAID 130000822219