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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/04 04:06:35」(JST)

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Succinylation is a posttranslational modification where a succinyl group (-CO-CH₂-CH₂-CO-) is added to a lysine residue of a protein molecule. This modification is found in many proteins, including histones.^[1] The potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 and introduces a relatively large structural moiety (bigger than during acetylation or methylation), it is expected to lead to more significant changes in protein structure and function.^[2]

By analogy to acetylation, it has been suggested that succinyl-CoA is the cofactor of enzyme-mediated lysine succinylation.

References

^ Xie, Z.; Dai, J.; Dai, L.; Tan, M.; Cheng, Z.; Wu, Y.; Boeke, J. D.; Zhao, Y. (2012). "Lysine succinylation and lysine malonylation in histones". Molecular & Cellular Proteomics. 11 (5): 100–7. doi:10.1074/mcp.M111.015875. PMID 22389435.
^ Zhang, Z.; Tan, M.; Xie, Z.; Dai, L.; Chen, Y.; Zhao, Y. (2010). "Identification of lysine succinylation as a new post-translational modification". Nature Chemical Biology. 7 (1): 58–63. doi:10.1038/nchembio.495. PMC 3065206. PMID 21151122.

External links

Succinylation, Yet A Novel PTM Pathway for Biological Regulation, But Ready to Be Investigated
Succinyl group at ChEBI

English Journal

Preparation of iron bound succinylated milk protein concentrate and evaluation of its stability.

Shilpashree BG1, Arora S2, Sharma V3, Bajaj RK4, Tomar SK5.
Food chemistry.Food Chem.2016 Apr 1;196:800-7. doi: 10.1016/j.foodchem.2015.10.020. Epub 2015 Nov 13.
Major problems associated with the fortification of soluble iron salts include chemical reactivity and incompatibility with other components. Milk protein concentrate (MPC) are able to bind significant amount of iron due to the presence of both casein and whey protein. MPC in its native state posses
PMID 26593557

Green route to modification of wood waste, cellulose and hemicellulose using reactive extrusion.

Vaidya AA1, Gaugler M2, Smith DA2.
Carbohydrate polymers.Carbohydr Polym.2016 Jan 20;136:1238-50. doi: 10.1016/j.carbpol.2015.10.033. Epub 2015 Oct 22.
A large volume of wood waste is produced in timber processing industry which traditionally used in low value applications. Here, value addition to the wood waste (Sander dust) and cellulose, hemicellulose isolated thereof by functionalisation using cyclic anhydrides in a solvent-free and green react
PMID 26572467

Effect of succinylation on functional and morphological properties of starches from broken kernels of Pakistani Basmati and Irri rice cultivars.

Moin A1, Ali TM2, Hasnain A3.
Food chemistry.Food Chem.2016 Jan 15;191:52-8. doi: 10.1016/j.foodchem.2015.03.119. Epub 2015 Apr 2.
Starch extracted from broken kernels of Basmati and Irri rice varieties of Pakistani rice were subjected to modification by addition of succinic anhydride at levels of 2%, 4% and 5% based on dried weight of starch. The succinyl content of Irri rice starch increased with the concentration of succinic
PMID 26258701

Japanese Journal

Development of an Enzyme-Linked Immunosorbent Assay System to Determine the Presence of Antibodies Specific for Taxane Structures

Muto Satoshi,Kouyama Yuichi,Yokoyama Yuusaku,Okuno Hiroaki,Ishii Toshihiro,Masaka Toru,Matsuzawa Yasuo,Kawashima Tatsuo,Shirai Koji
Biological & Pharmaceutical Bulletin 34(4), 562-566, 2011
… After the succinylation reaction, three different products were obtained, and these were confirmed as 7-succinoyl DAB (7-DAB), 10-succinoyl DAB (10-DAB), and 7,10-disuccinoyl DAB (7,10-DAB) by 1H-NMR analysis. …
NAID 130000657848