subcapsular

adj.

(眼の)嚢下の

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1. 網膜色素変性症：治療 retinitis pigmentosa treatment
2. 吸入ステロイドの主な副作用 major side effects of inhaled glucocorticoids
3. 成人における白内障 cataract in adults
4. 網膜色素変性症：臨床症状および診断 retinitis pigmentosa clinical presentation and diagnosis
5. 筋強直性ジストロフィー：病因、臨床的特徴、および診断 myotonic dystrophy etiology clinical features and diagnosis

English Journal

Molecular characterization and expression of porcine Siglec-5.

Escalona Z1, Alvarez B1, Uenishi H2, Toki D2, Yuste M1, Revilla C1, Gómez Del Moral M3, Alonso F1, Ezquerra A1, Domínguez J4.Author information 1Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain.2National Institute of Agrobiological Sciences (NIAS), 2 Ikenodai, Tsukuba, Ibaraki 305-8602, Japan.3Dpto. de Biología Celular, Facultad de Medicina, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040 Madrid, Spain.4Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra de la Coruña Km 7.5, 28040 Madrid, Spain. Electronic address: juncal@inia.es.AbstractIn this study we describe the characterization of the porcine orthologue of Siglec-5. A cDNa clone was obtained from a porcine cDNa library derived from swine small intestine which encodes a 555 a-a type 1 transmembrane protein with sequence homology to human Siglec-5. This protein consists of four Ig-like domains, a transmembrane region, and a cytoplasmic tail with two tyrosine-based signalling motifs. When expressed as a recombinant protein fused to the Fc region of human IgG1, porcine Siglec-5 was able to bind porcine red blood cells in a sialic acid-dependent manner. Monoclonal antibodies (mAb) were developed against porcine Siglec-5 and used to analyse its expression in bone marrow and blood cells, and lymphoid tissues. Porcine Siglec-5 expression was mainly restricted to myelomonocytic cells and their precursors, being detected also, although at low levels, on plasmacytoid dendritic cells and B lymphocytes. In lymphoid tissues, ellipsoids of the spleen and subcapsular and medullar sinuses of lymph nodes were positive for Siglec-5. These mAbs were able to precipitate, from granulocyte lysates, a protein of approximately 85kDa under non-reducing conditions, indicating that porcine Siglec-5 is expressed as a monomer in the plasma membrane.
Developmental and comparative immunology.Dev Comp Immunol.2014 May;44(1):206-16. doi: 10.1016/j.dci.2013.12.013. Epub 2013 Dec 29.
In this study we describe the characterization of the porcine orthologue of Siglec-5. A cDNa clone was obtained from a porcine cDNa library derived from swine small intestine which encodes a 555 a-a type 1 transmembrane protein with sequence homology to human Siglec-5. This protein consists of four
PMID 24382335

Key architectural changes in tumor-negative lymph nodes from metastatic-free oral cancer patients are valuable prognostic factors.

Vered M1, Schiby G, Schnaiderman-Shapiro A, Novikov I, Bello IO, Salo T, Rytkönen A, Kauppila JH, Dobriyan A, Yahalom R, Taicher S, Dayan D.Author information 1Institute of Pathology, The Chaim Sheba Medical Center, Tel Hashomer, Israel, lmy@netvision.net.il.AbstractRegional lymph node (LN) metastasis in oral cancer patients is the most significant grave prognostic factor. We evaluated the relationship between clinical outcomes and different histopathological changes in tumor-negative LNs (LN0) selected from neck dissections without metastatic disease (pN0). A total of 435 LN0 selected from pN0 neck dissections (up to three nodes in each level) were scored for histopathological parameters of LN areas, capsule thickness, subcapsular and medullary sinus ectasia, lobular architecture and percent of cortical reactive follicles. These were compared to 328 LN0 selected from neck dissections with metastases (pN+) after exclusion of metastatic LNs. Data were presented by maximum scores of each parameter in I-III (close) and in IV-V (distant) levels. Limited data from level V and regression analyses inferred that the values in level IV represented the worst changes for most patients. Cox proportional hazard regression on each parameter in close and distant levels demonstrated that capsule thickness, number of lobules and percent of reactive follicles were significantly associated with time to death from disease. The higher the change in distant levels, the shorter the time to death, while the higher the change in close levels (given a stable change in distant levels), the longer the time to death. After adjustment for gender, age and location, only the effect of the percent of reactive follicles retained their significant effect. Logistic regression of metastases demonstrated that all parameters except for percent of reactive follicles were significantly associated with risk of metastases, with differences between close and distant levels similar to those found for time to death. After adjustment for gender, age and location, only the area and number of lobes retained their significance. The findings of this study suggested that selective histopathological changes in tumor-negative LNs in metastatic-free patients provide new valuable prognostic parameters.
Clinical & experimental metastasis.Clin Exp Metastasis.2014 Mar;31(3):327-38. doi: 10.1007/s10585-013-9631-4. Epub 2014 Jan 7.
Regional lymph node (LN) metastasis in oral cancer patients is the most significant grave prognostic factor. We evaluated the relationship between clinical outcomes and different histopathological changes in tumor-negative LNs (LN0) selected from neck dissections without metastatic disease (pN0). A
PMID 24395336

Hepatic tumours in children with biliary atresia: Single-centre experience in 13 cases and review of the literature.

Yoon HJ1, Jeon TY2, Yoo SY1, Kim JH1, Eo H1, Lee SK3, Kim JS4.Author information 1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.2Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address: hathor97.jeon@samsung.com.3Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.4Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.AbstractAIM: To establish the risks of developing of hepatic tumours and to investigate their clinical and imaging findings in children with biliary atresia (BA) after Kasai portoenterostomy (Kasai).
Clinical radiology.Clin Radiol.2014 Mar;69(3):e113-9. doi: 10.1016/j.crad.2013.10.017. Epub 2013 Dec 9.
AIM: To establish the risks of developing of hepatic tumours and to investigate their clinical and imaging findings in children with biliary atresia (BA) after Kasai portoenterostomy (Kasai).MATERIALS AND METHODS: Among 157 children who had undergone Kasai for BA over an 18 year period, patients who
PMID 24332171

Japanese Journal

内視鏡超音波ガイド下経胃的膵仮性嚢胞ドレナージにより治療した腎被膜下嚢胞の1例

木村博子,神波大己,熱田雄 [他]
泌尿器科紀要 58(8), 421-424, 2012-08
NAID 40019387933

白内障手術時に得られた前嚢における水晶体上皮細胞のアポトーシス

山本香織/篠崎和美/堀貞夫
東京女子医科大学雑誌 82(E1), E101-E108, 2012-01-31
目的:白内障において、水晶体上皮細胞がアポトーシスに陥っている数および分布を観察し、さらにこれらと、白内障に影響する因子との関連があるか検討したので報告する。,対象および方法:対象は、白内障手術時に水晶体前嚢片の採取が可能であった29眼である。全身疾患および背景因子は、糖尿病があるものは13例15眼、糖尿病がないものは11例14眼で、この中にはアトピー性皮膚炎1例1眼、ステロイド全身投与歴2例3眼 …
NAID 110008767960

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