stress-activated protein kinase

ストレス活性化タンパク質キナーゼ

WordNet

1. to stress, single out as important; "Dr. Jones emphasizes exercise in addition to a change in diet" (同)emphasize, emphasise, punctuate, accent, accentuate
2. special emphasis attached to something; "the stress was more on accuracy than on speed" (同)focus
3. difficulty that causes worry or emotional tension; "she endured the stresses and strains of life"; "he presided over the economy during the period of the greatest stress and danger"- R.J.Samuelson (同)strain
4. (physics) force that produces strain on a physical body; "the intensity of stress is expressed in units of force divided by units of area"
5. the relative prominence of a syllable or musical note (especially with regard to stress or pitch); "he put the stress on the wrong syllable" (同)emphasis, accent
6. put stress on; utter with an accent; "In Farsi, you accent the last syllable of each word" (同)accent, accentuate
7. aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
8. make (substances) radioactive
9. make active or more active; "activate an old file"
10. make more adsorptive; "activate a metal"
11. rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
12. (of e.g. a molecule) made reactive or more reactive (同)excited
13. (military) set up and placed on active assignment; "a newly activated unit"
14. (of sewage) treated with aeration and bacteria to aid decomposition
15. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
16. suffering severe physical strain or distress; "he dropped out of the race, clearly distressed and having difficulty breathing" (同)distressed
17. bearing a stress or accent; "an iambic foot consists of an unstressed syllable followed by a stressed syllable as in `delay" (同)accented

PrepTutorEJDIC

1. 〈U〉〈C〉(精神的・感情的な)『緊張』,ストレス / 〈U〉(…に対する)『強調』,力説《+on+名》 / 〈C〉〈U〉『強勢』,アクセント / 〈U〉(一般に)『圧迫』,圧力 / …‘を'『強調する』,力説する / 〈音節・語〉‘に'強勢(アクセント)を置く / 《まれ》（に）圧力をかける
2. …'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
3. 蛋白(たんばく)質

UpToDate Contents

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• 1. Reperfusion injury of the heart
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• 3. Hypertrophic cardiomyopathy: Gene mutations and clinical genetic testing
• 4. Factor V Leiden and activated protein C resistance
• 5. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia

English Journal

• Stress contributes to the development of central insulin resistance during aging: Implications for Alzheimer's disease.

• Solas M, Aisa B, Tordera RM, Mugueta MC, Ramírez MJ.SourceDepartment of Pharmacology, University of Navarra, 31008 Pamplona, Spain.
• Biochimica et biophysica acta.Biochim Biophys Acta.2013 Dec;1832(12):2332-9. doi: 10.1016/j.bbadis.2013.09.013. Epub 2013 Oct 1.
• It is becoming evident that chronic exposure to stress not only might result in insulin resistance or cognitive deficits, but may also be considered a risk factor for pathologies such as depression or Alzheimer's disease (AD). There is great interest in determining the molecular mechanisms underlyin
• PMID 24090692

• Effects of paeoniflorin on tumor necrosis factor-α-induced insulin resistance and changes of adipokines in 3T3-L1 adipocytes.

• Kong P, Chi R, Zhang L, Wang N, Lu Y.SourceDepartment of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Diseases, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, No.639, Zhizhaoju Road, Shanghai 200211, Shanghai, China. Electronic address: porenkong@gmail.com.
• Fitoterapia.Fitoterapia.2013 Dec;91:44-50. doi: 10.1016/j.fitote.2013.08.010. Epub 2013 Aug 23.
• TNFα plays an important role in the adipocyte dysfunction, including lipolysis acceleration, insulin resistance and changes of adipokines. Recently, we showed that paeoniflorin attenuates adipocyte lipolysis and inhibits the phosphorylation of ERK, JNK, IKK stimulated by TNFα. However, the effects
• PMID 23978582

• The ATF/CREB Transcription Factor Atf1 Is Essential for Full Virulence, Deoxynivalenol Production, and Stress Tolerance in the Cereal Pathogen Fusarium graminearum.

• Van Nguyen T, Kröger C, Bönnighausen J, Schäfer W, Bormann J.AbstractFusarium graminearum is a necrotrophic plant pathogen of cereals that produces mycotoxins such as deoxynivalenol (DON) and zearalenone (ZEA) in grains. The stress-activated mitogen-activated protein kinase FgOS-2 is a central regulator in F. graminearum and controls, among others, virulence and DON and ZEA production. Here, we characterized the ATF/CREB-activating transcription factor FgAtf1, a regulator that functions downstream of FgOS-2. We created deletion and overexpression mutants of Fgatf1, the latter being also in an FgOS-2 deletion mutant. FgAtf1 localizes to the nucleus and appears to interact with FgOS-2 under osmotic stress conditions. Deletion mutants in Fgatf1 (ΔFgatf1) are more sensitive to osmotic stress and less sensitive to oxidative stress compared with the wild type. Furthermore, sexual reproduction is delayed. ΔFgatf1 strains produced higher amounts of DON under in vitro induction conditions than that of the wild type. However, during wheat infection, DON production by ΔFgatf1 is strongly reduced. The ΔFgatf1 strains displayed strongly reduced virulence to wheat and maize. Interestingly, constitutive expression of Fgatf1 in the wild type led to hypervirulence on wheat, maize, and Brachypodium distachyon. Moreover, constitutive expression of Fgatf1 in the ΔFgOS-2 mutant background almost complements ΔFgOS-2-phenotypes. These data suggest that FgAtf1 may be the most important transcription factor regulated by FgOS-2.
• Molecular plant-microbe interactions : MPMI.Mol Plant Microbe Interact.2013 Dec;26(12):1378-94. doi: 10.1094/MPMI-04-13-0125-R.
• Fusarium graminearum is a necrotrophic plant pathogen of cereals that produces mycotoxins such as deoxynivalenol (DON) and zearalenone (ZEA) in grains. The stress-activated mitogen-activated protein kinase FgOS-2 is a central regulator in F. graminearum and controls, among others, virulence and DON
• PMID 23945004

Japanese Journal

• The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress Response

• PLOS genetics 11(9), e1005491, 2015-09
• NAID 120005672644

• Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice

• FEBS Letters 589(19), 2805-2811, 2015-07-03
• NAID 120005661921

• p38の機能と阻害薬の動向

• 日本薬理学雑誌 145(1), 21-26, 2015
• NAID 130004827711

Related Links

• The stress-activated protein kinase pathways.

15 Aug 1999 ... Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase pathways. This results in modification of ...

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★リンクテーブル★

リンク元	「ストレス活性化タンパク質キナーゼ」
関連記事	「stress」「activated」「activate」「kinase」「protein kinase」

「ストレス活性化タンパク質キナーゼ」

　　[★]

英

stress-activated protein kinase

「stress」

　　[★]

• n.

• ストレス、緊張、応力、力点

• v.

• 強調する

関

accent、accentuate、accentuation、emphasis、emphasize、highlight、power point、strain、tone、tonus、underscore

　 　 　 　 　 　 　

「activated」

　　[★]

• adj.

• 活性化の、活性化型の、賦活化の

関

activate、activated form、activation、turn on

　 　 　 　

「activate」

　　[★]

• v.

• 活性化する、賦活化する、賦活する

関

activated、activation、turn on

　 　 　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「protein kinase」

　　[★] プロテインキナーゼ

同

protein kinases