ストレプトグラミン ストレプトグラミン系抗生物質
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/09 23:44:10」(JST)
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Streptogramins are a class of antibiotics.[1]
Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A and streptogramin B.
Members include:
- Quinupristin/dalfopristin
- Pristinamycin
- Virginiamycin
- NXL 103, an experimental streptogramin in clinical trials for the treatment of respiratory tract infections.[2]
References
- ^ University of Leeds: Antimicrobial Chemotherapy
- ^ Boucheer HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, et al. Bad Bugs, no drugs: No ESKAPE! An Update from the Infectious Society of America. Clin Infect Dis. 2009;48:1-12.
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Antibacterials: protein synthesis inhibitors (J01A, J01B, J01F, J01G, QJ01XQ)
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| 30S |
Aminoglycosides
(initiation inhibitors) |
| -mycin (Streptomyces) |
- Streptomycin#
- Dihydrostreptomycin
- Neomycin#
- Framycetin
- Paromomycin
- Ribostamycin
- Kanamycin#
- Amikacin
- Arbekacin
- Bekanamycin
- Dibekacin
- Tobramycin
- Spectinomycin#
- Hygromycin B
|
|
| -micin (Micromonospora) |
- Gentamicin#
- Netilmicin
- Sisomicin
- Plazomicin†
- Isepamicin
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|
|
Tetracycline antibiotics
(tRNA binding) |
| Tetracyclines |
- Doxycycline#
- Chlortetracycline
- Clomocycline
- Demeclocycline
- Lymecycline
- Meclocycline
- Metacycline
- Minocycline
- Oxytetracycline
- Penimepicycline
- Rolitetracycline
- Tetracycline
|
|
| Glycylcyclines |
|
|
| Fluorocyclines |
|
|
|
|
| 50S |
Oxazolidinone
(initiation inhibitors) |
- Eperezolid
- Linezolid
- Posizolid
- Radezolid
- Ranbezolid
- Sutezolid
- Tedizolid
|
|
| Peptidyl transferase |
| Amphenicols |
- Chloramphenicol#
- Azidamfenicol
- Thiamphenicol
- Florfenicol
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|
| Pleuromutilins |
- Retapamulin
- Tiamulin
- Valnemulin
|
|
|
| MLS (transpeptidation/translocation) |
| Macrolides |
- Azithromycin#
- Clarithromycin
- Dirithromycin
- Erythromycin#
- Flurithromycin
- Josamycin
- Midecamycin
- Miocamycin
- Oleandomycin
- Rokitamycin
- Roxithromycin
- Spiramycin
- Troleandomycin
- Tylosin
- Ketolides
- Telithromycin
- Cethromycin
- Solithromycin†
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|
| Lincosamides |
- Clindamycin#
- Lincomycin
- Pirlimycin
|
|
| Streptogramins |
- Pristinamycin
- Quinupristin/dalfopristin
- Virginiamycin
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|
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| EF-G |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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UpToDate Contents
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English Journal
- Clostridium difficile erm(B)-containing elements and the burden on the in vitro fitness.
- Wasels F, Spigaglia P, Barbanti F, Mastrantonio P.SourceIstituto Superiore di Sanità
- Journal of medical microbiology.J Med Microbiol.2013 Jun 5. [Epub ahead of print]
- In Clostridium difficile, resistance to the macrolide-lincosamide-streptogramin B group of antibiotics generally relies on erm(B) genes. In this study, we investigated elements with a genetic organisation different from Tn5398, the mobilizable non-conjugative element identified in C. difficile strai
- PMID 23741023
- Detection and new genetic environment of the pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in methicillin-resistant Staphylococcus aureus of swine origin.
- Li B, Wendlandt S, Yao J, Liu Y, Zhang Q, Shi Z, Wei J, Shao D, Schwarz S, Wang S, Ma Z.SourceShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China.
- The Journal of antimicrobial chemotherapy.J Antimicrob Chemother.2013 Jun;68(6):1251-5. doi: 10.1093/jac/dkt015. Epub 2013 Feb 5.
- OBJECTIVES: To investigate the genetic basis of pleuromutilin resistance in porcine methicillin-resistant Staphylococcus aureus (MRSA) and to map the genetic environment of the identified plasmid-borne resistance gene.METHODS: Seventy porcine MRSA isolates, which exhibited high MICs of tiamulin, val
- PMID 23386262
Japanese Journal
- MLSB構成型耐性黄色ブドウ球菌に対するYM133の特異的作用機序
- 北海道科学大学研究紀要 = Bulletin of Hokkaido University of Science (39), 15-20, 2015-03-30
- NAID 120005574668
- MLS[B]構成型耐性黄色ブドウ球菌に対するYM133 の特異的作用機序
- 研究紀要 = Bulletin of Hokkaido University of Science (39), 15-20, 2014
- NAID 40020456610
- 誘導型MLS[B]耐性黄色ブドウ球菌におけるマクロライド系薬の耐性誘導能の定量化
- 研究紀要 = Bulletin of Hokkaido University of Science (39), 21-26, 2014
- NAID 120005574669
Related Links
- Streptograminとは？goo Wikipedia (ウィキペディア) 。出典：Wikipedia（ウィキペディア）フリー百科事典。 Streptograminとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへスキップ ...
- 1. Curr Drug Targets. 2002 Aug;3(4):335-44. Streptogramin antibiotics: mode of action and resistance. Johnston NJ(1), Mukhtar TA, Wright GD. Author information: (1)Antimicrobial Research Centre, Department ...
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