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any of several fat-soluble organic compounds having as a basis 17 carbon atoms in four rings; many have important physiological effects

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ステロイド(脂肪溶解性の有機化合物の総称)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/05 23:11:50」(JST)

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Steroid sulfatase (or steryl-sulfatase), formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.^[1]

Function[edit]

The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors the free steroid. This includes sulfated androgens and sulfated estrogens. The encoded protein is found in the endoplasmic reticulum, where it is present as a homodimer.^[1]

Clinical significance[edit]

A deficiency is associated with X-linked ichthyosis, a scaly-skin disease affecting roughly 1 in every 2,000-6,000 males.^[2]^[3]

References[edit]

^ ^a ^b "Entrez Gene: STS steroid sulfatase (microsomal), arylsulfatase C, isozyme S".
^ Alperin ES, Shapiro LJ (August 1997). "Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein". J. Biol. Chem. 272 (33): 20756–63. doi:10.1074/jbc.272.33.20756. PMID 9252398.
^ Ghosh D (December 2004). "Mutations in X-linked ichthyosis disrupt the active site structure of estrone/DHEA sulfatase". Biochim. Biophys. Acta 1739 (1): 1–4. doi:10.1016/j.bbadis.2004.09.003. PMID 15607112.

External links[edit]

Steryl-Sulfatase at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. ステロイドの中断 glucocorticoid withdrawal
2. ステロイドの全身投与の主な副作用 major side effects of systemic glucocorticoids
3. ステロイドの薬理学的使用 pharmacologic use of glucocorticoids
4. 早産による新生児の罹病および死亡を減少させるための出産前ステロイド療法 antenatal corticosteroid therapy for reduction of neonatal morbidity and mortality from preterm delivery
5. 気管支肺異形成症におけるステロイドの生後使用 postnatal use of glucocorticoids in bronchopulmonary dysplasia

English Journal

Genetic analysis of a 12-year-old boy with X-linked ichthyosis in association with sclerosing glomerulonephritis.

Song Y, Chen J, Yi Z, Dang X, Cheng D, Wu X, Tan Y.SourceDivision of Pediatric Nephrology, Department of Pediatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China.
Molecular medicine reports.Mol Med Rep.2013 Oct;8(4):1183-7. doi: 10.3892/mmr.2013.1625. Epub 2013 Aug 12.
In this study, we report the case of a 12-year-old male with X-linked ichthyosis (XLI) in association with glomerular sclerosis, and our investigation into the deletion pattern of the STS gene and the flanking regions in DNA samples of family members. We observed no features typical of renal osteody
PMID 23939749

17β-ESTRADIOL AND ESTRADIOL FATTY ACYL ESTERS AND ESTROGEN-CONVERTING ENZYME EXPRESSION IN ADIPOSE TISSUE IN OBESE MEN AND WOMEN.

Wang F, Vihma V, Soronen J, Turpeinen U, Hämäläinen E, Savolainen-Peltonen H, Mikkola TS, Naukkarinen J, Pietiläinen KH, Jauhiainen M, Yki-Järvinen H, Tikkanen MJ.SourceaFolkhälsan Research Center, Biomedicum Helsinki, 00290 Helsinki, Finland.
The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2013 Sep 30. [Epub ahead of print]
Context:Obesity is associated with increased circulating 17β-estradiol (E2) but less is known about E2 concentrations in adipose tissue. In addition to E2, adipose tissue synthesizes E2 fatty acyl esters (E2-FAE).Objective:The aim was to compare estrogen concentrations and expression of estrogen-co
PMID 24081738

Xp22.3 interstitial deletion: A recognizable chromosomal abnormality encompassing VCX3A and STS genes in a patient with X-linked ichthyosis and mental retardation.

Ben Khelifa H, Soyah N, Ben-Abdallah-Bouhjar I, Gritly R, Sanlaville D, Elghezal H, Saad A, Mougou-Zerelli S.SourceCytogenetic and Reproductive Biology Department, Farhat Hached University Teaching Hospital, Sousse, Tunisia; Common Service Units for Research in Genetics, Faculty of Medicine of Sousse, University of Sousse, Street Mohamed Karoui, Tunisia.
Gene.Gene.2013 Sep 25;527(2):578-83. doi: 10.1016/j.gene.2013.06.018. Epub 2013 Jun 18.
X-linked ichthyosis is a genetic disorder affecting the skin and caused by a deficit in the steroid sulfatase enzyme (STS), often associated with a recurrent microdeletion at Xp22.31. Most of the STS deleted patients have X-linked ichthyosis as the only clinical feature and it is believed that patie
PMID 23791652

Japanese Journal

水疱性類天疱瘡を合併したX連鎖性劣性魚鱗癬の1例

皮膚の科学 14(1), 12-16, 2015
NAID 130005076099

PS-146-4 Estrogen Receptor(ER)陽性乳癌におけるSteroid Sulfatase(STS)とOrganic Anion Transporter Peptide(OATP) 4A1の新規バイオマーカーとしての可能性(PS-146 乳腺基礎-2,ポスターセッション,第114回日本外科学会定期学術集会)

日本外科学会雑誌 115(臨時増刊号_2), 866, 2014-03-05
NAID 110009871070

Functional characterization of seven single-nucleotide polymorphisms of the steroid sulfatase gene found in a Japanese population

Journal of human genetics 58(5), 267-272, 2013-05-01
NAID 10031177221

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リンク元	「ステロイドスルファターゼ」「steryl-sulfatase」
関連記事	「sulfatase」

「ステロイドスルファターゼ」

Steroid sulfatase (microsomal), isozyme S
	; PDB rendering based on 1p49.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1P49
Identifiers
Symbols	STS; ARSC; ARSC1; ASC; ES; SSDD; XLI
External IDs	OMIM: 300747 HomoloGene: 47918 ChEMBL: 3559 GeneCards: STS Gene
EC number	3.1.6.2
Gene Ontology
Molecular function	• steryl-sulfatase activity; • sulfuric ester hydrolase activity; • metal ion binding;
Cellular component	• lysosome; • endosome; • endoplasmic reticulum; • endoplasmic reticulum lumen; • endoplasmic reticulum membrane; • Golgi apparatus; • plasma membrane; • membrane; • integral to membrane; • intracellular membrane-bounded organelle;
Biological process	• sphingolipid metabolic process; • glycosphingolipid metabolic process; • steroid catabolic process; • female pregnancy; • epidermis development; • post-translational protein modification; • cellular protein metabolic process; • small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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