WordNet

any of several fat-soluble organic compounds having as a basis 17 carbon atoms in four rings; many have important physiological effects
an enzyme that catalyzes its substrate to an isomeric form

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Extraordinarily high aldosterone, 901.0 ng/dL, in a patient with primary aldosteronism: an insight into the underlying mechanism.

Okubo Y1, Sato Y, Nakasone Y, Shirotori K, Oguchi K, Matsushita T, Nishikawa T, Yamazaki Y, Sasano H, Komatsu M, Yamauchi K, Aizawa T.
Endocrine journal.Endocr J.2016 Feb 29;63(2):127-33. doi: 10.1507/endocrj.EJ15-0398. Epub 2015 Nov 7.
A 43-yr-old hypertensive male was admitted due to hypokalemia (1.8 mEq/L) and renal dysfunction (eGFR, 20.0 mL/min/1.73 m(2)). His plasma aldosterone was 901.0 ng/dL, plasma renin activity 5.7 ng/mL/hr, and aldosterone/renin activity ratio 158. Angiotensin II (AII) was 0.7 pg/mL, ACTH <1.0 pg/mL,
PMID 26549209

Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.

Liu Y1, Su X2, Hao J3, Chen M4, Liu W5, Liao X6, Li G7.
International journal of molecular sciences.Int J Mol Sci.2016 Jan 13;17(1). pii: E96. doi: 10.3390/ijms17010096.
Prolactin family 7, subfamily d, member 1 (PRL7D1) is found in mouse placenta. Our recent work showed that PRL7D1 is also present in mouse testis Leydig cells, and the expression of PRL7D1 in the testis exhibits an age-related increase. In the present study, we generated transgenic mice with Leydig
PMID 26771609

The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases.

Rižner TL1.
Frontiers in pharmacology.Front Pharmacol.2016 Feb 18;7:30. doi: 10.3389/fphar.2016.00030. eCollection 2016.
Gynecological diseases such as endometriosis, adenomyosis and uterine fibroids, and gynecological cancers including endometrial cancer and ovarian cancer, affect a large proportion of women. These diseases are estrogen dependent, and their progression often depends on local estrogen formation. In pe
PMID 26924986

Immunolocalization of murine type VI 3β-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta.

Yamamura Koki,Doi Masao,Hayashi Hida,Ota Takumi,Murai Iori,Hotta Yunhong,Komatsu Rie,Okamura Hitoshi
Molecular and cellular endocrinology 382(1), 131-138, 2013-09-25
… The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is essential for the biosynthesis of all active steroid hormones, such as those secreted from the adrenal gland, testis, ovary, skin and placenta. … However, potential contributions of this enzyme to the steroid hormone synthesis outside the adrenal glands are poorly understood. …
NAID 120005347108

The Activity and Localization of 3β-hydroxysteroid Dehydrogenase/Δ⁵-Δ⁴ Isomerase and Release of Androstenedione and Progesterone by Uterine Tissues During Early Pregnancy and the Estrous Cycle in Pigs

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Journal of Reproduction and Development 59(1), 49-58, 2013
… Steroid hormones are produced by the porcine uterus. … We hypothesized that the uterus in pigs possesses active 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) responsible for progesterone and androstenedione production, that uterine steroids may supplement the amount of steroid hormones produced by embryos and corpus luteum and that these steroids are necessary for maintenance of pregnancy. …
NAID 130001854905

Horinouchi Masae,Hayashi Toshiaki,Kudo Toshiaki
The Journal of steroid
… Steroid degradation by Comamonas testosteroni and Nocardia restrictus have been intensively studied for the purpose of obtaining materials for steroid drug synthesis. … testosteroni degrades side chains and converts single/double bonds of certain steroid compounds to produce androsta-1,4-diene 3,17-dione or the derivative. …
NAID 120002769903