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- 1. Long-term antiplatelet therapy after coronary artery stenting in stable patients
- 2. 冠動脈ステント使用の一般原則 general principles of the use of intracoronary stents
- 3. ベアメタル冠動脈ステントと比較した薬剤溶出性冠動脈ステント drug eluting compared to bare metal intracoronary stents
- 4. 冠動脈ステント血栓症：発症率および危険因子 coronary artery stent thrombosis incidence and risk factors
- 5. 薬剤溶出性冠動脈ステントの比較 comparison of drug eluting intracoronary stents
- New stent surface materials: The impact of polymer-dependent interactions of human endothelial cells, smooth muscle cells, and platelets.
- Busch R1, Strohbach A2, Rethfeldt S2, Walz S2, Busch M2, Petersen S3, Felix S2, Sternberg K3.Author information 1University of Greifswald, Clinic for Internal Medicine B, Sauerbruchstraße, D-17475 Greifswald, Germany. Electronic address: firstname.lastname@example.orgUniversity of Greifswald, Clinic for Internal Medicine B, Sauerbruchstraße, D-17475 Greifswald, Germany.3University of Rostock, Institute for Biomedical Engineering, Friedrich-Barnewitz-Strasse 4, D-18119 Rostock, Germany.AbstractDespite the development of new coronary stent technologies, in-stent restenosis and stent thrombosis are still clinically relevant. Interactions of blood and tissue cells with the implanted material may represent an important cause of these side effects. We hypothesize material-dependent interaction of blood and tissue cells. The aim of this study is accordingly to investigate the impact of vascular endothelial cells, smooth muscle cells and platelets with various biodegradable polymers to identify a stent coating or platform material that demonstrates excellent endothelial-cell-supportive and non-thrombogenic properties. Human umbilical venous endothelial cells, human coronary arterial endothelial cells and human coronary arterial smooth muscle cells were cultivated on the surfaces of two established biostable polymers used for drug-eluting stents, namely poly(ethylene-co-vinylacetate) (PEVA) and poly(butyl methacrylate) (PBMA). We compared these polymers to new biodegradable polyesters poly(l-lactide) (PLLA), poly(3-hydroxybutyrate) (P(3HB)), poly(4-hydroxybutyrate) (P(4HB)) and a polymeric blend of PLLA/P(4HB) in a ratio of 78/22% (w/w). Biocompatibility tests were performed under static and dynamic conditions. Measurement of cell proliferation, viability, glycocalix width, eNOS and PECAM-1 mRNA expression revealed strong material dependency among the six polymer samples investigated. Only the polymeric blend of PLLA/P(4HB) achieved excellent endothelial markers of biocompatibility. Data show that PLLA and P(4HB) tend to a more thrombotic response, whereas the polymer blend is characterized by a lower thrombotic potential. These data demonstrate material-dependent endothelialization, smooth muscle cell growth and thrombogenicity. Although polymers such as PEVA and PBMA are already commonly used for vascular implants, they did not sufficiently meet the criteria for biocompatibility. The investigated biodegradable polymeric blend PLLA/P(4HB) evidently represents a promising material for vascular stents and stent coatings.
- Acta biomaterialia.Acta Biomater.2014 Feb;10(2):688-700. doi: 10.1016/j.actbio.2013.10.015. Epub 2013 Oct 19.
- Despite the development of new coronary stent technologies, in-stent restenosis and stent thrombosis are still clinically relevant. Interactions of blood and tissue cells with the implanted material may represent an important cause of these side effects. We hypothesize material-dependent interaction
- PMID 24148751
- On high-cycle fatigue of 316L stents.
- Barrera O, Makradi A, Abbadi M, Azaouzi M, Belouettar S.Author information a Henri Tudor Research Center , 29, Avenue John F. Kennedy, L-1855 , Luxembourg , G.D. of Luxembourg.AbstractThis paper deals with fatigue life prediction of 316L stainless steel cardiac stents. Stents are biomedical devices used to reopen narrowed vessels. Fatigue life is dominated by the cyclic loading due to the systolic and diastolic pressure and the design against premature mechanical failure is of extreme importance. Here, a life assessment approach based on the Dang Van high cycle fatigue criterion and on finite element analysis is applied to explore the fatigue reliability of 316L stents subjected to multiaxial fatigue loading. A finite element analysis of the stent vessel subjected to cyclic pressure is performed to carry out fluctuating stresses and strain at some critical elements of the stent where cracks or complete fracture may occur. The obtained results show that the loading path of the analysed stent subjected to a pulsatile load pressure is located in the safe region concerning infinite lifetime.
- Computer methods in biomechanics and biomedical engineering.Comput Methods Biomech Biomed Engin.2014 Feb;17(3):239-50. doi: 10.1080/10255842.2012.677442. Epub 2012 May 16.
- This paper deals with fatigue life prediction of 316L stainless steel cardiac stents. Stents are biomedical devices used to reopen narrowed vessels. Fatigue life is dominated by the cyclic loading due to the systolic and diastolic pressure and the design against premature mechanical failure is of ex
- PMID 22587434
- Modelling intravascular delivery from drug-eluting stents with biodurable coating: investigation of anisotropic vascular drug diffusivity and arterial drug distribution.
- Zhu X, Pack DW, Braatz RD.Author information a Department of Chemical Engineering , Massachusetts Institute of Technology , Cambridge , MA 02139 , USA.AbstractIn-stent restenosis occurs in coronary arteries after implantation of drug-eluting stents with non-uniform restenosis thickness distribution in the artery cross section. Knowledge of the spatio-temporal drug uptake in the arterial wall is useful for investigating restenosis growth but may often be very expensive/difficult to acquire experimentally. In this study, local delivery of a hydrophobic drug from a drug-eluting stent implanted in a coronary artery is mathematically modelled to investigate the drug release and spatio-temporal drug distribution in the arterial wall. The model integrates drug diffusion in the coating and drug diffusion with reversible binding in the arterial wall. The model is solved by the finite volume method for both high and low drug loadings relative to its solubility in the stent coating with varied isotropic-anisotropic vascular drug diffusivities. Drug release profiles in the coating are observed to depend not only on the coating drug diffusivity but also on the properties of the surrounding arterial wall. Time dependencies of the spatially averaged free- and bound-drug levels in the arterial wall on the coating and vascular drug diffusivities are discussed. Anisotropic vascular drug diffusivities result in slightly different average drug levels in the arterial wall but with very different spatial distributions. Higher circumferential vascular diffusivity results in more uniform drug loading in the upper layers and is potentially beneficial in reducing in-stent restenosis. An analytical expression is derived which can be used to determine regions in the arterial with higher free-drug concentration than bound-drug concentration.
- Computer methods in biomechanics and biomedical engineering.Comput Methods Biomech Biomed Engin.2014 Feb;17(3):187-98. doi: 10.1080/10255842.2012.672815. Epub 2012 Apr 18.
- In-stent restenosis occurs in coronary arteries after implantation of drug-eluting stents with non-uniform restenosis thickness distribution in the artery cross section. Knowledge of the spatio-temporal drug uptake in the arterial wall is useful for investigating restenosis growth but may often be v
- PMID 22512464
- Clinical outcomes following percutaneous coronary intervention before and after introduction of drug-eluting stent
- Cardiovascular intervention and therapeutics 30(4), 338-346, 2015-10
- NAID 40020631637
- EDITORIAL : Late Failure of First-Generation Drug-Eluting Stents in Hemodialysis Patients
- Circulation journal : official journal of the Japanese Circulation Society 79(10), 2103-2105, 2015-10
- NAID 40020593288
- Two-Year Clinical Outcomes of Newer-Generation Drug-Eluting Stent Implantation Following Rotational Atherectomy for Heavily Calcified Lesions
- Circulation journal : official journal of the Japanese Circulation Society 79(9), 1938-1943, 2015-09
- NAID 40020565710
- A stent is a small mesh tube that's used to treat narrow or weak arteries. Arteries are blood vessels that carry blood away from your heart to other parts of your body. A stent is placed in an artery as part of a procedure ...
- 2015-08-21 第5回技術講習会のお知らせ 掲載しました。 2015-05-15 第33回研究会：開催案内、座長・演者案内、会場案内 更新 ... 日本Metallic Stents & Grafts研究会 事務局 奈良県立医科大学 放射線医学教室 〒634-8522 橿原市 ...
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