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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/21 10:48:20」(JST)

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Spongiosis is mainly intercellular^[1] edema (abnormal accumulation of fluid) in the epidermis,^[2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification.^[3]

Additional images

Histopathological image of dyshidrotic dermatitis, showing focal spongiotic change in the epidermis.

References

^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. Chapter: Clinical and Pathologic Differential Diagnosis. ISBN 1-4160-2999-0.
^ Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
^ Marks, James G; Miller, Jeffery (2006). Lookingbill and Marks' Principles of Dermatology (4th ed.). Elsevier Inc. Page 28. ISBN 1-4160-3185-5.

UpToDate Contents

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1. 皮膚炎の概要 overview of dermatitis
2. アレルギー性接触皮膚炎の臨床的特徴および診断 clinical features and diagnosis of allergic contact dermatitis
3. 蕁麻疹性皮膚炎 urticarial dermatitis
4. Nail psoriasis
5. 皮膚の異型リンパ球浸潤と診断された患者に対するアプローチ approach to the patient with a diagnosis of atypical lymphocytic infiltrate of the skin

English Journal

Dynamic skin changes of acute radiation dermatitis revealed by in vivo reflectance confocal microscopy.

Vano-Galvan S, Fernandez-Lizarbe E, Truchuelo M, Diaz-Ley B, Grillo E, Sanchez V, Ríos-Buceta L, Paoli J, Sancho S, Montero A, Hernanz R, Ramos A, Jaen P, Gonzalez S.SourceDermatology Department, Ramon y Cajal University Hospital, Madrid, Spain Oncology Radiotherapy Department, Ramon y Cajal University Hospital, Madrid, Spain.
Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2013 Sep;27(9):1143-50. doi: 10.1111/j.1468-3083.2012.04680.x. Epub 2012 Aug 11.
Background A better knowledge of the dynamic biological changes that the skin undergoes in response to ionizing radiation is advisable to improve the management of radiation dermatitis, allowing selection of patients needing treatment or close monitoring. Objective To describe the evolution of
PMID 22882643

The spectrum of histopathologic patterns secondary to the topical application of EMLA(®) on vulvar epithelium: clinicopathological correlation in three cases.

Lewis FM, Agarwal A, Neill SM, Calonje JE, Stefanato CM.SourceSt John's Institute of Dermatology, Guy's & St Thomas' NHS Trust, London, UK.
Journal of cutaneous pathology.J Cutan Pathol.2013 Aug;40(8):708-13. doi: 10.1111/cup.12155. Epub 2013 Apr 17.
EMLA(®) (eutectic mixture of local anesthetics, 2.5% each of lidocaine and prilocaine in an oil and water emulsion) is used as a topical anesthetic. We report three cases of EMLA(®) -induced histopathologic changes on the vulvar epithelium. While there are some similar histopathologic features to
PMID 23590164

Unique N-Linked Glycosylation of CasBrE Env Influences Its Stability, Processing, and Viral Infectivity but Not Its Neurotoxicity.

Renszel KM, Traister RS, Lynch WP.SourceDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA.
Journal of virology.J Virol.2013 Aug;87(15):8372-87. doi: 10.1128/JVI.00392-13. Epub 2013 May 22.
The envelope protein (Env) from the CasBrE murine leukemia virus (MLV) can cause acute spongiform neurodegeneration analogous to that induced by prions. Upon central nervous system (CNS) infection, Env is expressed as multiple isoforms owing to differential asparagine (N)-linked glycosylation. Becau
PMID 23698308

Japanese Journal

Gastric mucosal changes induced by polyethylene glycol 400 administered by gavage in rats

UEDA Yoshihide,TSUBOI Masaru,OTA Yasufumi,MAKITA Maki,AOSHIMA Takuya,NAKAJIMA Madoka,NARAMA Isao
Journal of toxicological sciences 36(6), 811-815, 2011-12-01
… The changes consisted of infiltration of eosinophils and globule leukocytes, increased in the height of the entire mucosal layer, elongation of the surface mucous epithelial and mucous neck cell layers with increased intracellular mucous in the glandular stomach, and the spongiosis (intercellular edema) of the squamous epithelium in the forestomach. …
NAID 10030037050

症例報告遠心性環状紅斑(表在型)の1例

浜野真紀,中島広子,玉木毅
臨床皮膚科 65(2), 123-126, 2011-02-00
NAID 40018714188

シクロスポリンにより顕在化したセザリー症候群の1例

岩田洋平,小寺雅也,臼田俊和,豊田徳子,大城宏治,山岡俊文,村上榮,西村景子,松永佳世子
Skin Cancer 26(3), 316-322, 2011
　66歳，女性。2007年頃より近医で慢性湿疹として加療を続けるも難治であったため，2010年8月からシクロスポリンを開始された。内服開始約2ヵ月後に，皮疹の増悪を主訴に当科を受診した。皮膚生検では表皮内にCD4陽性異型リンパ球の密な浸潤を認め，末梢血にも異型リンパ球を認めた。Southern blot法を用いてTCR遺伝子再構成を検索したところ，cβ1遺伝子の再構成バンドが検出された。シクロスポ …
NAID 130002149386