スピラプリラート、スピラプリラト
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/18 21:51:47」(JST)
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Systematic (IUPAC) name |
(8S)-7-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid |
Clinical data |
Legal status |
?
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Identifiers |
ATC code |
? |
UNII |
QS56V5Y7EC Y |
ChEMBL |
CHEMBL579 |
Chemical data |
Formula |
H26N2O5S2 |
Mol. mass |
438.6 g/mol |
SMILES
- C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
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InChI
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InChI=InChI=1S/C20H26N2O5S2/c1-13(21-15(18(24)25)8-7-14-5-3-2-4-6-14)17(23)22-12-20(28-9-10-29-20)11-16(22)19(26)27/h2-6,13,15-16,21H,7-12H2,1H3,(H,24,25)(H,26,27)/t13-,15-,16-/m0/s1
Key:FMMDBLMCSDRUPA-BPUTZDHNSA-N
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Spiraprilat is the active metabolite of Spirapril.
English Journal
- Accurate aqueous proton dissociation constants calculations for selected angiotensin-converting enzyme inhibitors.
- Sramko M1, Smiesko M, Remko M.
- Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2008 Jun;25(6):599-608.
- Studies that allow computing values of aqueous proton dissociation constants (pKa), gas phase proton affinities, and the free energy of solvation have been performed for six members of angiotensin-I-converting enzyme (ACE) inhibitor family (captopril, enalaprilat, imidaprilat, ramiprilat, perindopri
- PMID 18399693
- Drug interaction of spirapril hydrochloride monohydrate and hydrochlorothiazide. A clinical study to compare the pharmacokinetics after administration of spirapril hydrochloride monohydrate tablets, hydrochlorothiazide tablets and fixed combination bi-layer tablets.
- Schürer M1, Erb K, Junge K, Schäfer HF, Schulz HU, Amschler S, Krupp S, Hermann R.
- Arzneimittel-Forschung.Arzneimittelforschung.2003;53(6):414-9.
- The potential influence of concomitantly administered hydrochlorothiazide (CAS 58-93-5) on the pharmacokinetics of spirapril (CAS 94841-17-5)/spiraprilat (CAS 83602-05-5) and of concomitantly administered spirapril on the pharmacokinetics of hydrochlorothiazide was investigated in an open, randomise
- PMID 12872612
- Simultaneous determination of spirapril and spiraprilat in plasma by capillary gas chromatography-mass spectrometry.
- Schürer M1, Amschler S, Schulz HU, Schäfer HF.
- Arzneimittel-Forschung.Arzneimittelforschung.2003;53(5):307-13.
- A specific, sensitive and precise method for the simultaneous determination of spirapril (CAS 94841-17-5) and spiraprilat (CAS 83602-05-5) in human plasma is described. The method involves the use of enalapril as internal standard, solid-phase extraction, derivatization and capillary gas chromatogra
- PMID 12854357
Related Links
- Pharmacokinetic (PK) study The PK study was performed, in each individual patient, similarly for spirapril and spiraprilat with the Siphar pharmacokinetic software (14). Peak concentration (C max, ng/ml) and time to peak ...
- Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension. Noble, S., Sorkin, E.M. Drugs (1995) [Pubmed] Pharmacokinetic-pharmacodynamic model relating spiraprilat plasma ...
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スピラプリル
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