- 関
- spirapril
WordNet
- a complex consisting of an organic base in association with hydrogen chloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/04/27 14:37:42」(JST)
[Wiki en表示]
Spirapril
|
Systematic (IUPAC) name |
(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
|
Clinical data |
Trade names |
Renormax |
AHFS/Drugs.com |
International Drug Names |
Pregnancy
category |
|
Routes of
administration |
Oral |
Legal status |
Legal status |
|
Pharmacokinetic data |
Bioavailability |
50% |
Metabolism |
converted to spiraprilat |
Biological half-life |
30 to 35 hours |
Excretion |
Hepatic and renal |
Identifiers |
CAS Number |
83647-97-6 Y |
ATC code |
C09AA11 (WHO) |
PubChem |
CID 5311447 |
IUPHAR/BPS |
6575 |
DrugBank |
DB01348 N |
ChemSpider |
4470933 Y |
UNII |
96U2K78I3V Y |
KEGG |
D08529 Y |
ChEMBL |
CHEMBL431 Y |
Chemical data |
Formula |
C22H30N2O5S2 |
Molar mass |
466.616 g/mol |
SMILES
-
O=C(OCC)[C@@H](N[C@H](C(=O)N2[C@H](C(=O)O)CC1(SCCS1)C2)C)CCc3ccccc3
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InChI
-
InChI=1S/C22H30N2O5S2/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27)/t15-,17-,18-/m0/s1 Y
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Key:HRWCVUIFMSZDJS-SZMVWBNQSA-N Y
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NY (what is this?) (verify) |
Spirapril hydrochloride (Renormax) is an ACE inhibitor antihypertensive drug used to treat hypertension. It belongs to dicarboxy group of ACE inhibitors.[citation needed]
Spiraprilat — the active metabolite
Like many ACE inhibitors, this prodrug is converted to the active metabolite spiraprilat following oral administration. Unlike other members of the group, it is eliminated both by renal and hepatic routes, which may allow for greater use in patients with renal impairment.[1] However, data on its effect upon the renal function are conflicting.[2]
References
- ^ Shohat J, Wittenberg C, Erman A, Rosenfeld J, Boner G (1999). "Acute and chronic effects of spirapril, alone or in combination with isradipine on kidney function and blood pressure in patients with reduced kidney function and hypertension.". Scand J Urol Nephrol 33 (1): 57–62. doi:10.1080/003655999750016294. PMID 10100366.
- ^ Noble S, Sorkin E (1995). "Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension.". Drugs 49 (5): 750–66. doi:10.2165/00003495-199549050-00008. PMID 7601014.
Antihypertensives: agents acting on the renin–angiotensin system (C09)
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ACE inhibitors
("-pril") |
- Sulfhydryl-containing: Captopril
- Rentiapril
- Zofenopril
- Dicarboxylate-containing: Enalapril#
- Benazepril
- Cilazapril
- Delapril
- Imidapril
- Lisinopril (+HCT)
- Moexipril
- Perindopril
- Quinapril (+HCT)
- Ramipril
- Spirapril
- Temocapril
- Trandolapril
- Phosphonate-containing: Fosinopril (+HCT)
- Other/ungrouped: Alacepril
|
|
AIIRAs/
("-sartan") |
- Azilsartan
- Candesartan
- Eprosartan
- Fimasartan
- Irbesartan
- Losartan (+HCT)
- Olmesartan (+amlodipine)
- Tasosartan§
- Telmisartan (+HCT)
- Valsartan (+HCT, +amlodipine, +sacubitril)
|
|
Renin inhibitors/
("-kiren") |
- Aliskiren (+amlodipine, +amlodipine and HCT)
- Remikiren§
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
UpToDate Contents
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English Journal
- Administration-time differences in effects of hypertension medications on ambulatory blood pressure regulation.
- Hermida RC1, Ayala DE, Fernández JR, Mojón A, Smolensky MH, Fabbian F, Portaluppi F.
- Chronobiology international.Chronobiol Int.2013 Mar;30(1-2):280-314. doi: 10.3109/07420528.2012.709448. Epub 2012 Oct 19.
- Specific features of the 24-h blood pressure (BP) pattern are linked to progressive injury of target tissues and risk of cardiovascular disease (CVD) events. Several studies have consistently shown an association between blunted asleep BP decline and risk of fatal and nonfatal CVD events. Thus, ther
- PMID 23077971
- Perfusion calorimetry in the characterization of solvates forming isomorphic desolvates.
- Baronsky J1, Preu M, Traeubel M, Urbanetz NA.
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2011 Sep 18;44(1-2):74-82. doi: 10.1016/j.ejps.2011.06.008. Epub 2011 Jun 25.
- In this study, the potential of perfusion calorimetry in the characterization of solvates forming isomorphic desolvates was investigated. Perfusion calorimetry was used to expose different hydrates forming isomorphic desolvates (emodepside hydrates II-IV, erythromycin A dihydrate and spirapril hydro
- PMID 21726637
- Effect of angiotensin-converting enzyme inhibitor quadropril on dynamic parameters of vascular tone under conditions of NO synthesis blockade in normotensive and spontaneously hypertensive rats.
- Sonin DL1, Galagoudza MM, Syrensky AV, Tsyrlin VA.
- Bulletin of experimental biology and medicine.Bull Exp Biol Med.2011 Jul;151(3):311-3.
- The role of NO in the mechanism of quadropril modulation of the flow-dependent vasodilation was examined in normotensive (Wistar) and spontaneously hypertensive (SHR) rats. The abdominal aorta was cannulated and autoperfused at different volume rates to obtain the pressure-flow curves. In the first
- PMID 22451874
Related Links
- Buy Spirapril Hydrochloride (CAS 94841-17-5), an Angiotensin-converting enzyme (ACE) inhibitor, from Santa Cruz. MF: C22H31ClN2O5S2, MW: 503.07 ... アプリケーション: An Angiotensin-converting enzyme (ACE) inhibitor CAS ...
- LGM Pharma is a Spirapril Hydrochloride CAS# 83647-97-6 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more. ... LGM Pharma is a Spirapril Hydrochloride 83647-97-6 active pharmaceutical ingredient supplier distributor, based in the USA.
Related Pictures
★リンクテーブル★
[★]
- 英
- spirapril、spirapril hydrochloride
- 関
- 塩酸スピラプリル
[★]
- 英
- spirapril hydrochloride
- 関
- スピラプリル
[★]
スピラプリル
- 関
- spirapril hydrochloride
[★]
塩酸塩、ハイドロクロライド