English Journal

Modifications of Sphingolipid Content Affect Tolerance to Hemibiotrophic and Necrotrophic Pathogens by Modulating Plant Defense Responses in Arabidopsis.

Magnin-Robert M1, Le Bourse D1, Markham J1, Dorey S1, Clément C1, Baillieul F1, Dhondt-Cordelier S2.
Plant physiology.Plant Physiol.2015 Nov;169(3):2255-74. doi: 10.1104/pp.15.01126. Epub 2015 Sep 16.
Sphingolipids are emerging as second messengers in programmed cell death and plant defense mechanisms. However, their role in plant defense is far from being understood, especially against necrotrophic pathogens. Sphingolipidomics and plant defense responses during pathogenic infection were evaluate
PMID 26378098

Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy.

Wisse P1, de Geus MA1, Cross G1, van den Nieuwendijk AM1, van Rooden EJ1, van den Berg RJ1, Aerts JM1, van der Marel GA1, Codée JD1, Overkleeft HS1.
The Journal of organic chemistry.J Org Chem.2015 Jul 17;80(14):7258-65. doi: 10.1021/acs.joc.5b00823. Epub 2015 Jun 25.
In this paper, a new synthetic route toward 6-hydroxysphingosine and α-hydroxy ceramide is described. The synthesis employs a cross-metathesis to unite a sphingosine head allylic alcohol with a long-chain fatty acid alkene that also bears an allylic alcohol group. To allow for a productive CM coupl
PMID 26061009

Japanese Journal

4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin

Shirakura Yoshiyuki,Kikuchi Kanako,Matsumura Kenji,Mukai Katsuyuki,Mitsutake Susumu,Igarashi Yasuyuki
Lipids in Health and Disease 11, 108, 2012-08-31
… In this study, we assessed the effect of 4,8-sphingadienine (d18:2) and 4-hydroxy-8-sphingenine (t18:1), derived from konjac glucosylceramide, on stimulating ceramide production. … Results: We noted the upregulation of genes related to de novo ceramide synthesis as well as of those encoding the elongases of very long-chain fatty acids by d18:2 and t18:1, but not by glucosylceramide and 4-sphingenine. …
NAID 120004979562

Identification of glucosylceramides containing sphingatrienine in maize and rice using ion trap mass spectrometry.

Sugawara Tatsuya,Duan Jingjing,Aida Kazuhiko,Tsuduki Tsuyoshi,Hirata Takashi
Lipids 45(5), 451-455, 2010-05-00
… In addition, 4-hydroxy-8-sphingenine (t18:1) and sphingatrienine (d18:3) were found in maize and rice glucosylceramides, and in the case of rice, sphingenine (d18:1) was also detected. …
NAID 120002462969

Related Pictures

Sphingosine , sphinganine and Sphingosine (4 sphingenine; 4-sphingenine) Sphingénine Sphingosine -1-phosphate (S1P) erythro- Sphingosine | CAS Fig. 2. Stereoisomers of sphingenine.