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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/13 23:54:35」(JST)

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Novel protein-protein interaction between spermidine synthase and S-adenosylmethionine decarboxylase from Leishmania donovani.

Mishra AK1, Agnihotri P1, Srivastava VK1, Venkatesh Pratap J2.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2014 Dec 13. pii: S0006-291X(14)02173-1. doi: 10.1016/j.bbrc.2014.12.008. [Epub ahead of print]
Polyamine biosynthesis pathway has long been considered an essential drug target for trypanosomatids including Leishmania. S-adenosylmethionine decarboxylase (AdoMetDc) and spermidine synthase (SpdSyn) are enzymes of this pathway that catalyze successive steps, with the product of the former, decarb
PMID 25511700

The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.

Oliverio S1, Corazzari M, Sestito C, Piredda L, Ippolito G, Piacentini M.
Amino acids.Amino Acids.2014 Dec;46(12):2767-76. doi: 10.1007/s00726-014-1821-0. Epub 2014 Sep 14.
The exogenous administration of spermidine promotes longevity in many model organisms. It has been proposed that this anti-age activity of spermidine is related to this polyamine's ability to promote autophagy. Since spermidine is the substrate for the eIF5A post-translational modification by hypusi
PMID 25218134

Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients.

Bandino A1, Geerts D, Koster J, Bachmann AS.
Cellular oncology (Dordrecht).Cell Oncol (Dordr).2014 Dec;37(6):387-98. doi: 10.1007/s13402-014-0201-9. Epub 2014 Oct 15.
PURPOSE: Neuroblastoma (NB) is an aggressive pediatric malignancy that typically occurs in infants and children under the age of 5 years. High-stage tumors relapse frequently even after aggressive multimodal treatment, resulting in therapy resistance and eventually in patient death. Clearly, new bi
PMID 25315710

Overexpression of apple spermidine synthase 1 (MdSPDS1) leads to significant salt tolerance in tomato plants

Neily Mohamed Hichem,Baldet Pierre,Arfaoui Issam [他],SAITO Takeshi,LI Qiu-li,ASAMIZU Erika,MATSUKURA Chiaki,MORIGUCHI Takaya,EZURA Hiroshi
Plant biotechnology 28(1), 33-42, 2011-03-25
… The aim of this research is to study the effects of salt stress during different stages of development in transgenic tomato plants overexpressing the apple spermidine synthase gene (MdSPDS1) compared to wild type (WT) plants. … These changes were more prominent in WT plants compared to MdSPDS1 transgenic plants which accumulate significantly more polyamines, namely spermine and spermidine. …
NAID 10028258500

Enhanced polyamine accumulation alters carotenoid metabolism at the transcriptional level in tomato fruit over-expressing spermidine synthase

Neily Mohamed Hichem,Matsukura Chiaki,Maucourt Mickaël,Bernillon Stéphane,Deborde Catherine,Moing Annick,Yin Yong-Gen,Saito Takeshi,Mori Kentaro,Asamizu Erika,Rolin Dominique,Moriguchi Takaya,Ezura Hiroshi,松倉千昭,斉藤岳士,森健太郎,浅水恵理香,江面浩
Journal of plant physiology 168(3), 242-252, 2011-02
… We generated transgenic tomato plants that show a 1.5- to 2-fold increase in polyamine content by over-expressing the spermidine synthase gene, which encodes a key enzyme for polyamine biosynthesis. …
NAID 120003039690

Spermidine regulates insulin synthesis and cytoplasmic Ca[2+] in mouse beta-TC6 insulinoma cells