somatomedin

ソマトメジン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/19 03:11:22」(JST)

wiki en

[Wiki en表示]

Somatomedins are produced, predominantly by the liver, when growth hormones act on target tissue. Somatomedins inhibit the release of growth hormones by acting directly on anterior pituitary and by stimulating the secretion of somatostatin from the hypothalamus.

Somatomedins are a group of hormones that promote cell growth and division in response to stimulation by growth hormone (GH) also known as somatotropin (STH).

Somatomedins have similar biological effects to somatotropin.

In addition to their actions that stimulate growth, somatomedins also stimulate production of somatostatin, which suppresses growth hormone release. Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. Somatomedins are produced in many tissues and have autocrine and paracrine actions in addition to their endocrine action. The liver is thought to be the predominant source of circulating somatomedins.

Three forms include:

• somatomedin A, which is another name for insulin-like growth factor 2 (IGF-2)
• somatomedin B, which is derived from vitronectin
• somatomedin C, which is another name for insulin-like growth factor 1 (IGF-1)

References

External links

• Somatomedins at the US National Library of Medicine Medical Subject Headings (MeSH)
• Brs physiology

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. インスリン様成長因子 Iの生理学 physiology of insulin like growth factor i
• 2. 成長ホルモン不感受性症候群 growth hormone insensitivity syndromes
• 3. 小児における成長ホルモン欠乏症の治療 treatment of growth hormone deficiency in children
• 4. 先端巨大症の診断 diagnosis of acromegaly
• 5. 小児における成長ホルモン欠乏症の診断 diagnosis of growth hormone deficiency in children

English Journal

• miR-29, a potential therapeutic target for liver fibrosis.

• Bian EB1, Li J1, Zhao B2.
• Gene.Gene.2014 Jul 10;544(2):259-60. doi: 10.1016/j.gene.2014.04.076. Epub 2014 May 2.
• PMID 24792894

• GATA-4 induces changes in electrophysiological properties of rat mesenchymal stem cells.

• Li HX1, Zhou YF1, Jiang B1, Zhao X1, Jiang TB1, Li X1, Yang XJ2, Jiang WP1.
• Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jun;1840(6):2060-9. doi: 10.1016/j.bbagen.2014.02.020. Epub 2014 Feb 26.
• BACKGROUND: Transplanted mesenchymal stem cells (MSC) can differentiate into cardiac cells that have the potential to contribute to heart repair following ischemic injury. Overexpression of GATA-4 can significantly increase differentiation of MSC into cardiomyocytes (CM). However, the specific impac
• PMID 24582939

• Epigenetic regulation of the Igf2/H19 gene cluster.

• Nordin M1, Bergman D, Halje M, Engström W, Ward A.
• Cell proliferation.Cell Prolif.2014 Jun;47(3):189-99. doi: 10.1111/cpr.12106. Epub 2014 Apr 16.
• Igf2 (insulin-like growth factor 2) and H19 genes are imprinted in mammals; they are expressed unevenly from the two parental alleles. Igf2 is a growth factor expressed in most normal tissues, solely from the paternal allele. H19 gene is transcribed (but not translated to a protein) from the materna
• PMID 24738971

Japanese Journal

• 先端巨大症に伴う下顎前突症に対して顎矯正手術を施行した1例 : 骨格・咬合・鼻形態の変化

• 嵐山 貴徳,宮城 尚史,福田 純一,齋藤 功,高木 律男
• 日本顎変形症学会雑誌 = The Japanese journal of jaw deformities 21(1), 18-29, 2011-04-15
• … The GH and somatomedin levels were high. … Subsequently, since the GH and somatomedin levels decreased almost to the normal ranges, preoperative orthodontic treatment was initiated, and bilateral sagittal splitting ramus osteotomy was performed 18 months after the tumor resection. …
• NAID 10030789224

• The Relation between Concentric and Eccentric Exercise and the Carbohydrate Metabolism in Healthy Individuals

• バイオフィリア リハビリテーション研究 6(1), 27-34, 2010
• … Venous blood samples were drawn before and immediately after the test, and during 1-hour recovery for the determinations of hormonal and somatomedin concentrations. …
• NAID 130004937787

• The Relation between Concentric and Eccentric Exercise and the Carbohydrate Metabolism in Healthy Individuals

• ZEBROWSKA Aleksandra
• バイオフィリア リハビリテーション研究 6(1), 27-34, 2010
• … Venous blood samples were drawn before and immediately after the test, and during 1-hour recovery for the determinations of hormonal and somatomedin concentrations. …
• NAID 130000657800

Related Links

• IGF - Tokyo Metropolitan Institute of Gerontology

SOMATOMEDIN A IGF1R; INSULIN-LIKE GROWTH FACTOR I RECEPTOR キーワード インスリン様成長因子、成長ホルモン、IGFシグナル経路、癌 歴史とあらまし インスリン様成長因子（IGF）は成長ホルモンによる作用を仲介 する ...

• Somatomedin | definition of somatomedin by Medical dictionary

somatomedin [so″mah-to-me´din] any of a group of peptides found in the liver and in other tissues which mediate the effect of growth hormone (somatotropin) on cartilage; they are responsible for uptake of sulfate and increased ...

Related Pictures

---

★リンクテーブル★

リンク元	「インスリン様成長因子-I」「ソマトメジン」
拡張検索	「somatomedin receptor」「somatomedin-like substance」

「インスリン様成長因子-I」

　　[★]

英

insulin-like growth factor I insuline-like growth factor-I IGF-I IGF-1

同

インスリン様増殖因子I、インスリン様成長因子I。ソマトメジンC somatomedin C, ソマトメジン somatomedin

性状

• ペプチド

産生組織

• 肝臓を始めとする多くの臓器

標的組織

• 血行性にホルモンとして、自己分泌的、傍分泌的に作用。

作用

• IGF-IはGH依存性に種々の組織で合成、分泌され、主にオートクリン作用によって組織の増殖を促進する。

分泌の調整

• 分泌促進：成長ホルモン、インスリン
• 分泌抑制：絶食(GH↑だが)、エストロゲン、コルチゾール

「ソマトメジン」

　　[★]

英

somatomedin (PT), SM

同

インスリン様成長因子-I, IGF-I

関

インスリン様成長因子, インスリン様成長因子

→ インスリン様成長因子-I

• 肝臓で産生
• 成長ホルモンの生理作用発現のために必要らしい (PT.412)

「somatomedin receptor」

　　[★]

• ソマトメジン受容体、ソマトメジンレセプター

関

insulin-like growth factor receptor

「somatomedin-like substance」

　　[★] ソマトメジン活性物質