WordNet

a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/12 20:06:53」(JST)

wiki en

Sodium picosulfate (INN, also known as sodium picosulphate) is a contact laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery. It is sold under the trade names Sodipic Picofast, Laxoberal, Laxoberon,^[1] Purg-Odan, Picolax, Picoprep,^[2] Guttalax, and Pico-Salax^[3] among others.

Effects

Orally administered sodium picosulfate is generally used for thorough evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It works very quickly, so access to a toilet at all times is recommended. It starts off by making bowel movements looser and more frequent, but within an hour or so of taking it the patient should experience diarrhea.

The most common side effects of picosulfate are abdominal cramps and diarrhea.

The use of sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia.^[4] Patients are often required to drink large amounts of clear fluids to restablish the electrolyte balance as well as rehydrate.^[5]

References

^ Website of Merck Pakastan
^ Picoprep study at ingentaconnect 'Picoprep-3 Is a Superior Colonoscopy Preparation to Fleet: A Randomized, Controlled Trial Comparing the Two Bowel Preparations' study at St George Hospital, Sydney, NSW, Australia
^ PICO SALAX Product Information
^ ADRAC (February 2002). "Electrolyte disturbances with sodium picosulfate bowel cleansing products". Aust Adv Drug React Bull 21 (1). Free full text from the Australian Therapeutic Goods Administration
^ http://www.odanlab.com/picodan/purgodan/PurgOdan_patient_en.pdf

UpToDate Contents

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1. S状結腸鏡検査および大腸内視鏡検査のための前処置 bowel preparation for flexible sigmoidoscopy and colonoscopy
2. 成人における慢性便秘の管理 management of chronic constipation in adults

English Journal

Lack of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel group, multiple dose study in healthy lactating women.

Friedrich C, Richter E, Trommeshauser D, Kruif SD, Iersel TV, Mandel K, Gessner U.SourceTranslational Medicine, Boehringer Ingelheim Pharma GmbH & Co. KG.
Drug metabolism and pharmacokinetics.Drug Metab Pharmacokinet.2011 Jun 21. [Epub ahead of print]
Objective: The study-aim was to determine if administration of the prodrugs bisacodyl (Bisa) and sodium picosulfate (SPS) leads to excretion of their common active metabolite, BHPM in breast milk. Methods: Two groups of 8 healthy lactating women who stopped breast feeding, received multiple doses of
PMID 21697613

Service implications of implementing guidance for oral bowel cleansing agents in colonoscopy.

Flanagan PK, Ahmed MS, Tin SM, Sarkar S.SourceDepartment of Gastroenterology, Royal Liverpool University Hospital, Prescot Street, Liverpool, UK.
The journal of the Royal College of Physicians of Edinburgh.J R Coll Physicians Edinb.2011 Jun;41(2):100-5.
INTRODUCTION: Bowel preparation has led to serious adverse events. Consequently, regulatory and advisory bodies have issued guidance,including a risk stratification of patients,aiming to minimise this risk.AIMS: To determine the impact of the new guidance on our current practice of Picolax used in c
PMID 21677910

Japanese Journal

下痢モデルラット腸管組織内及び血漿中Peptide-YY(PYY)の変動とその治療薬Loperamideの影響

廣谷芳彦,三河尻恭子,池田賢二,名徳倫明,黒川信夫
藥學雜誌 128(9), 1311-1316, 2008-09-01
… In rats administered castor oil and sodium picosulfate, the intestinal mucosal PYY levels significantly decreased in a dose-dependent manner. …
NAID 110006873989

一般開業医のよく使う小児便秘の治療薬 : アンケート調査結果(東京女子医科大学東医療センター小児科開局40周年記念論文集)

岡田和子,若林康子,杉原茂孝
東京女子医科大学雑誌 77(臨時増刊号), E75-E77, 2007-05-31
… Medicine used for the constipation is most frequently glycerin enema in infants, followed by sodium picosulfate hydrate and senna. … In primary-school children sodium picosulfate hydrate is used most frequently, then senna, while in the older children mainly senna is used. …
NAID 110007525357

Related Pictures

★リンクテーブル★

リンク元	「ピコスルファート」

「ピコスルファート」

Sodium picosulfate
Systematic (IUPAC) name
	disodium (pyridin-2-ylmethylene)di-4,1-phenylene disulfate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	10040-45-6
ATC code	A06AB08; A06AB58 (combinations)
PubChem	CID 68654
ChemSpider	61910
UNII	LR57574HN8
Chemical data
Formula	C18H13NNa2O8S2
Mol. mass	481.409 g/mol
	SMILES [Na+].[Na+].[O-]S(=O)(=O)Oc1ccc(cc1)C(c2ccc(OS([O-])(=O)=O)cc2)c3ncccc3;
	InChI InChI=1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2 ; Key:GOZDTZWAMGHLDY-UHFFFAOYSA-L ;
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　　[★]

英: picosulfate
化: ピコスルファートナトリウム sodium picosulfate
商: アペリール、コンスーベン、シンラック、スナイリン、スルチミン、チャルドール、ピコダルム、ピコベン、ピコルーラ、ファースルー、ファレスタック、フルレール、ベルベロン、ヨーピス、ラキソデート、ラキソベロン
関: 緩下薬。下剤，浣腸剤

大腸刺激性下剤

参考

ラキソベロン内用液0.75%

http://www.info.pmda.go.jp/go/pack/2359005S1240_1_03/2359005S1240_1_03?view=body

[0] Website of Merck Pakastan

[1] Picoprep study at ingentaconnect 'Picoprep-3 Is a Superior Colonoscopy Preparation to Fleet: A Randomized, Controlled Trial Comparing the Two Bowel Preparations' study at St George Hospital, Sydney, NSW, Australia

[2] PICO SALAX Product Information

[3] ADRAC (February 2002). "Electrolyte disturbances with sodium picosulfate bowel cleansing products". Aust Adv Drug React Bull 21 (1). Free full text from the Australian Therapeutic Goods Administration

[4] ttp://www.odanlab.com/picodan/purgodan/PurgOdan_patient_en.pdf

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案内

sodium picosulfate