イポダートナトリウム、イオポダートナトリウム
- 関
- calcium iopodate、calcium ipodate、iopodate、ipodate、sodium ipodate
WordNet
- a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
PrepTutorEJDIC
- ソジウム,ナトリウム(金属元素;化学記号はNa)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/06 09:06:06」(JST)
[Wiki en表示]
Ipodate sodium
|
Systematic (IUPAC) name |
sodium 3-(3-{[(dimethylamino)methylidene]amino}-2,4,6-triiodophenyl)propanoate
|
Clinical data |
Routes of
administration |
oral, Intravenous |
Identifiers |
CAS Number |
5587-89-3 |
ATC code |
V08AC08 |
PubChem |
CID: 14651 |
ChemSpider |
13984 |
ChEMBL |
CHEMBL1201033 |
Chemical data |
Formula |
C12H12I3N2NaO2 |
Molecular mass |
619.93906 g/mol |
SMILES
-
CN(C)/C=N/c1c(cc(c(c1I)CCC(=O)[O-])I)I.[Na+]
|
InChI
-
InChI=1S/C12H13I3N2O2.Na/c1-17(2)6-16-12-9(14)5-8(13)7(11(12)15)3-4-10(18)19;/h5-6H,3-4H2,1-2H3,(H,18,19);/q;+1/p-1/b16-6+;
-
Key:ZFHZUGUCWJVEQC-FPUQOWELSA-M
|
Physical data |
Melting point |
168–169 °C (334–336 °F) |
Ipodate sodium (sodium iopodate) is an iodine-containing radiopaque contrast media used for X-rays. The drug is given orally and the resulting contrast allows for easy resolution of the bile duct and gall bladder. The drug goes by the trade name Oragrafin or Gastrografin.[1]
Contents
- 1 Other uses
- 1.1 Graves' disease
- 1.2 Thyroid Storm
- 2 References
Other uses
Although not FDA approved, ipodate sodium has been used to treat Graves' disease and thyroid storm, an extreme form of hyperthyroidism.
Graves' disease
Long-term treatment of Graves' disease with ipodate sodium (500 mg, daily) given by mouth reduced levels of T3 and T4 in the patients.[2] This was done with minimal side effects, indicating possible clinical usefulness. Iodine uptake was also noted to return to normal within seven days, indicating control with ipodate with rapid follow up treatment with 131I is feasible.
Thyroid Storm
In emergency situations, ipodate can be administered for thyroid storm. As the ipodate is metabolized, it releases iodine into circulation, helping bring the T3 and T4 levels back down. Ipodate also inhibits the conversion of T4 to T3 (which is more potent). It is not considered a first-line approach, as potassium iodide and beta blockers have less potential for side-effects. Ipodate sodium lacks FDA approval for this use.
References
- ^ http://www.drugs.com/cons/cholecystographic-agent.html
- ^ DC Shen, SY Wu, IJ Chopra, HW Huang, LR Shian, TY Bian, CY Jeng and DH Solomon (1985). "Long term treatment of Graves' hyperthyroidism with sodium ipodate". Journal of Clinical Endocrinology & Metabolism 61 (4): 723–727. doi:10.1210/jcem-61-4-723. PMID 3928675.
Contrast media (V08)
|
|
X-ray and CT |
Iodinated,
Water soluble
|
Nephrotropic,
high osmolar
|
- Diatrizoic acid#
- Metrizoic acid
- Iodamide
- Iotalamic acid
- Ioxitalamic acid
- Ioglicic acid
- Acetrizoic acid
- Iocarmic acid
- Methiodal
- Diodone
|
|
Nephrotropic,
low osmolar
|
- Metrizamide
- Iohexol#
- Ioxaglic acid
- Iopamidol
- Iopromide
- Iotrolan
- Ioversol
- Iopentol
- Iodixanol
- Iomeprol
- Iobitridol
- Ioxilan
|
|
Hepatotropic
|
- Iodoxamic acid
- Iotroxic acid
- Ioglycamic acid
- Adipiodone
- Iobenzamic acid
- Iopanoic acid
- Iocetamic acid
- Sodium iopodate
- Tyropanoic acid
- Calcium iopodate
|
|
|
Iodinated,
Water insoluble
|
- Ethyl esters of iodised fatty acids
- Iopydol
- Propyliodone
- Iofendylate
- Lipiodol
|
|
Non-iodinated
|
|
|
|
MRI |
Paramagnetic
|
- Gadolinium-based: Gadobenic acid
- Gadobutrol
- Gadodiamide
- Gadofosveset
- Gadolinium
- Gadopentetic acid
- Gadoteric acid
- Gadoteridol
- Gadoversetamide
- Gadoxetic acid
Other: Ferric ammonium citrate
|
|
Superparamagnetic
|
- Ferumoxsil
- Ferristene
- Iron oxide, nanoparticles
|
|
Other
|
|
|
|
Ultrasound |
- Microspheres of human albumin
- Microparticles of galactose
- Perflenapent
- Microspheres of phospholipids
- Sulfur hexafluoride
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
Thyroid therapy (H03)
|
|
Thyroid hormones |
- Levothyroxine#
- Liothyronine
- Liotrix
- Tiratricol
- Thyroid gland preparations
|
|
Antithyroid preparations |
Thyroid peroxidase
inhibitors (thioamide) |
- Thiouracils: Propylthiouracil#
- Methylthiouracil
- Benzylthiouracil
- Sulfur-containing imidazole derivatives: Carbimazole
- Methimazole
|
|
Block conversion of
T4 to T3 |
- Propylthiouracil#
- Ipodate
|
|
Sodium-iodide symporter
inhibitor |
- Perchlorate (Potassium perchlorate)
- Pertechnetate (Sodium pertechnetate)
|
|
Other |
- Diiodotyrosine
- Dibromotyrosine
|
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
Index of hormones
|
|
Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
|
|
Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
|
|
Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
|
|
|
UpToDate Contents
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English Journal
- Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases.
- Laurberg P1, Vestergaard H, Nielsen S, Christensen SE, Seefeldt T, Helleberg K, Pedersen KM.
- The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2007 Jun;92(6):2149-56. Epub 2007 Mar 27.
- CONTEXT: Graves' hyperthyroidism and multinodular toxic goiter lead to high serum T(3) compared with serum T(4). The source of this high T(3) has not been clarified.OBJECTIVE: Our objective was to assess the role of iodothyronine deiodinase type 1 (D1) and type 2 (D2) for T(3) production and to esti
- PMID 17389703
- Hashimoto's thyroiditis and the role of selenium. Current concepts.
- Mazokopakis EE1, Chatzipavlidou V.
- Hellenic journal of nuclear medicine.Hell J Nucl Med.2007 Jan-Apr;10(1):6-8.
- Hashimoto's thyroiditis (HT) is part of the spectrum of autoimmune thyroid diseases. Clinical manifestations of HT are variable and commonly include diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. Uncommonly, HT causes acute destruction of thyroi
- PMID 17450242
- AuthorsCheng KT.
- Links to resources such as full text articles and biological data" class="jig-ncbitoggler ui-ncbitoggler" href="#
Full Text Sources
Miscellaneous
- PMID 20641974
Japanese Journal
- 経口胆嚢造影剤ビロプチン(Sodium Iopodate)の血液生化学検査に及ぼす影響
Related Links
- [ Sodium_iopodate]の項目はありません。情報提供元のWikipediaにはこの項目があるかもしれません。もし項目がない場合はWikipediaに参加してこの項目を追加しませんか?[Sodium_iopodate] の項目をWikipediaで探してみる。[Sodium ...
- 経口胆嚢造影剤ビロプチン(Sodium Iopodate)の血液生化学検査に及ぼす影響 長谷部 碩 この論文を読む・さがす NDL-OPAC - 国立国会図書館でさがす CiNii Books - 大学図書館でさがす 収録刊行物 横浜医学 横浜医学 33(1), p1-4 ...
- Sodium Iopodate C 12 H 12 I 3 N 2 NaO 2: 619.94 Monosodium 3 - [3 - (dimethylaminomethylene) amino - 2, 4, 6 - triiodophenyl] propionate CAS Registry Number: **CAUTION** File Download Conformational Distribution (Download ...
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- 英
- ipodate、iopodate、sodium ipodate、sodium iopodate、calcium ipodate、calcium iopodate
- 同
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- 英
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[★]
- 英
- sodium iopodate
- ラ
- natrii iopodas
- 商
- ビロプチン
- 関
- イポダート、イポダートカルシウム、イオポダートカルシウム、イオポダート、イポダートナトリウム
[★]
- 英
- sodium ipodate、sodium iopodate
- 関
- イ・ダート、イオ・ダートナトリウム、イ・ダートカルシウム、イオ・ダートカルシウム、イオ・ダート
[★]
イ・ダートカルシウム、イオ・ダートカルシウム
- 関
- calcium ipodate、iopodate、ipodate、sodium iopodate、sodium ipodate
[★]
イ・ダート、イオ・ダート
- 関
- calcium iopodate、calcium ipodate、ipodate、sodium iopodate、sodium ipodate