English Journal

[Successful treatment with oral low-dose sobuzoxane and etoposide combined with rituximab in an elderly patient with HHV-8-negative primary effusion lymphoma-like lymphoma].

Toyoda K1, Abe Y, Tsuda M, Haji S, Choi I, Suehiro Y, Kiyasu J, Ohshima K, Uike N.
[Rinshō ketsueki] The Japanese journal of clinical hematology.Rinsho Ketsueki.2014 Jul;55(7):815-9.
Primary effusion lymphoma (PEL) is a rare B-cell lymphoma, characterized by human herpes virus 8 (HHV8) infection and serous effusions without detectable tumor masses. However, cases with HHV8 unrelated PEL have also been reported, mainly in Japan, and these are referred to as PEL-like lymphoma (PEL
PMID 25098519

Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells.

Vavrova A1, Jansova H, Mackova E, Machacek M, Haskova P, Tichotova L, Sterba M, Simunek T.
PloS one.PLoS One.2013 Oct 7;8(10):e76676. doi: 10.1371/journal.pone.0076676. eCollection 2013.
Anthracyclines (such as doxorubicin or daunorubicin) are among the most effective anticancer drugs, but their usefulness is hampered by the risk of irreversible cardiotoxicity. Dexrazoxane (ICRF-187) is the only clinically approved cardioprotective agent against anthracycline cardiotoxicity. Its act
PMID 24116135

Lu DY1, Lu TR.
Anti-cancer agents in medicinal chemistry.Anticancer Agents Med Chem.2010 Sep;10(7):564-70.
Bisdioxopiperazine (Biz) compounds, including ICRF-154 and razoxane (ICRF-159, Raz), are anticancer agents developed in the UK specifically targeting tumor metastases. Further three bisdioxopiperazine derivatives, bimolane (Bim), probimane (Pro) and MST-16, have been synthesized at the Shanghai Inst
PMID 20950258

Japanese Journal

症例報告リツキシマブ併用ソブゾキサンおよびエトポシドの経口少量療法が奏効した高齢者ヒトヘルペスウイルス8陰性Primary effusion lymphoma-like lymphoma

松尾敦子,緒方亜紀,水足謙介,彌永和宏,城野昌義
西日本皮膚科 76(2), 115-120, 2014
2 回の急性転化を経て，19 年間にわたり経過観察できた慢性型成人 T 細胞白血病/リンパ腫 (ATLL) の症例を報告する。発症は 1991 年で，熊本大学医学部附属病院にて "慢性型 ATLL の急性転化" の診断の下, recombinant interleukin-1β (rIL-1β) による治療を開始し，治療開始 5 カ月後に完全寛解 (CR) が得られ，ATLL 関連の検査値異常すべ …
NAID 130004831871

リツキシマブ併用ソブゾキサンおよびエトポシドの経口少量療法が奏効した高齢者ヒトヘルペスウイルス8陰性Primary effusion lymphoma-like lymphoma

豊田康祐,安部康信,津田麻理子,土師正二郎,崔日承,末廣陽子,喜安純一,大島孝一,鵜池直邦
臨床血液 55(7), 815-819, 2014
Primary effusion lymphoma (PEL)は体腔液中に限局して腫瘍細胞が増殖する稀なB細胞性リンパ腫であり，原則的に明らかな腫瘤形成は認められないとされ，human herpes virus 8 (HHV8)感染が陽性である。しかしながら本邦を中心にHHV8感染が認められないPEL類似の症例も報告されており，これらをPEL-like lymphoma (PEL-LL)とする疾患 …
NAID 130004678960