WordNet
- any compound that contains water of crystallization
- become hydrated and combine with water
- cause to be hydrated; add water or moisture to; "hydrate your skin"
- supply water or liquid to in order to maintain a healthy balance; "the bicyclists must be hydrated frequently"
- a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
- small tubular solitary freshwater hydrozoan polyp
- trouble that cannot be overcome by a single effort because of its many aspects or its persistent and pervasive quality; "we may be facing a hydra that defies any easy solution"
PrepTutorEJDIC
- 含水化合物,水化物 / 〈化合物〉‘を'水和させて水化物を作る
- ソジウム,ナトリウム(金属元素;化学記号はNa)
UpToDate Contents
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- 1. 急性呼吸窮迫症候群：新しい治療法 acute respiratory distress syndrome novel therapies in adults
- 2. 難治性川崎病 refractory kawasaki disease
- 3. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
- 4. 急性腎障害（急性腎不全）におけるナトリウム（FENa）、尿素（FEUrea）、およびその他分子の排泄率 fractional excretion of sodium urea and other molecules in acute kidney injury acute renal failure
- 5. 腎集合管ナトリウムチャンネルの遺伝的障害：リドル症候群および偽性低アルドステロン症1型 genetic disorders of the collecting tubule sodium channel liddles syndrome and pseudohypoaldosteronism type 1
English Journal
- Sivelestat sodium hydrate reduces radiation-induced lung injury in mice by inhibiting neutrophil elastase.
- Yoshikawa N, Inomata T, Okada Y, Shimbo T, Takahashi M, Akita K, Uesugi Y, Narumi Y.SourceDepartment of Radiology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan. rad101@poh.osaka-med.ac.jp
- Molecular medicine reports.Mol Med Rep.2013 Apr;7(4):1091-5. doi: 10.3892/mmr.2013.1318. Epub 2013 Feb 8.
- The aim of this study was to investigate whether sivelestat, a neutrophil elastase (NE) inhibitor, mitigates radiation-induced lung injury in mice. C57BL/6J mice were administered a dose of 20 Gy to the bilateral whole lungs. Sivelestat was administered immediately before and 1 h after irradiation i
- PMID 23404144
- Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats.
- Fujimura N, Obara H, Suda K, Takeuchi H, Miyasho T, Kawasako K, Du W, Yamada S, Ono S, Matsumoto K, Matsuda S, Yagi H, Kitago M, Shinoda M, Itano O, Tanabe M, Sakamoto M, Maruyama I, Kitagawa Y.SourceDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
- The Journal of surgical research.J Surg Res.2013 Mar;180(1):e31-6. doi: 10.1016/j.jss.2012.04.037. Epub 2012 May 8.
- BACKGROUND: Sivelestat sodium hydrate is a specific neutrophil elastase inhibitor effective in acute lung injury (ALI) associated with systemic inflammatory response syndrome. Bowel ischemia reperfusion injury (IRI) induced by supravisceral aortic clamping is associated with an excessive systemic in
- PMID 22595015
- Emphysematous cystitis following a transrectal needle guided biopsy of the prostate.
- Hashimoto T, Namiki K, Tanaka A, Shimodaira K, Gondo T, Tachibana M.SourceDepartment of Urology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
- BMC infectious diseases.BMC Infect Dis.2012 Nov 26;12:322. doi: 10.1186/1471-2334-12-322.
- BACKGROUND: Emphysematous cystitis (EC) is a comparatively rare urinary tract infection characterized by air within the bladder wall and lumen and is usually associated with immunosuppression or poorly controlled diabetes mellitus.CASE PRESENTATION: We report a case of EC in a 70-year-old man who re
- PMID 23176639
Japanese Journal
- 研究・症例 呼吸器内科領域における急性肺損傷に対する好中球エラスターゼ阻害薬の効果について--有効例と無効例の臨床的検討
- 遠藤 健夫,谷田貝 洋平,箭内 英俊 [他]
- 日本胸部臨床 70(8), 852-862, 2011-08
- NAID 40018942453
- The Effect of Sivelestat Sodium Hydrate on Severe Respiratory Failure after Thoracic Aortic Surgery with Deep Hypothermia
- Morimoto Keisuke,Nishimura Kengo,Miyasaka Shigeto,Maeta Hiroyuki,Taniguchi Iwao
- Annals of Thoracic and Cardiovascular Surgery 17(4), 369-375, 2011
- … A specific neutrophil elastase inhibitor, sivelestat sodium hydrate, is an innovative therapeutic drug for acute lung injury. … We evaluated the protective effects of sivelestat sodium hydrate on severe lung injury after thoracic aortic surgery with deep hypothermia. …
- NAID 130000728025
- In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
- Morinaga Yoshitomo,Yanagihara Katsunori,Araki Nobuko,Yamada Koichi,Seki Masafumi,Izumikawa Koichi,Kakeya Hiroshi,Yamamoto Yoshihiro,Yamada Yasuaki,Kohno Shigeru,Kamihira Shimeru
- Experimental lung research 36(8), 484-490, 2010-10
- … Sivelestat sodium hydrate (sivelestat), a neutrophil elastase inhibitor, is used in the treatment of lung injury but its effect on bacterial pneumonia is unknown. … The authors examined the efficacy of sivelestat in combination with a fluoroquinolone in a Legionella pneumophila pneumonia mouse model. …
- NAID 120003367667
Related Links
- シベレスタットナトリウム水和物(Sivelestat sodium hydrate)の人工心肺後炎症反応 および肺障害に対する効果 Effects of neutrophil elastase inhibitor (Sivelestat sodium hydrate) on Systemic Inflammatory Response and Acute Lung Injury in ...
- Sigma-Aldrich offers Sigma-Sivelestat sodium salt hydrate for your research needs. Find product specific information, including CAS, MSDS, protocols and references.
Related Pictures
★リンクテーブル★
| リンク元 | 「シベレスタット」 |
| 関連記事 | 「hydrate」「sivelestat」「hydra」 |
「シベレスタット」
効能又は効果
- 注射用エラスポール100
- 全身性炎症反応症候群に伴う急性肺障害の改善
作用機序
- 注射用エラスポール100
- 好中球エラスターゼは蛋白分解酵素の一つであり、肺に集積した好中球から遊離される。好中球エラスターゼは肺結合組織を分解し、肺血管透過性を亢進させ、急性肺障害を誘発させる。また、好中球遊走因子の産生を促進し、炎症反応を増幅させ、全身性炎症反応症候群に伴う急性肺障害における重要な障害因子として注目されている。本剤は、好中球エラスターゼの選択的な阻害剤である。
参考
- 注射用エラスポール100
「hydrate」
- n.
- v.
- 水和させる、水分補給する
「sivelestat」
「hydra」
- 関
- Hydra