sex hormone-binding globulin

出典: meddic

性ホルモン結合グロブリン

SHBG
testosterone-estrogen-binding globulin
SHBG
SHBG
SHBG

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/21 01:41:39」(JST)

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英文文献

  • Premenopausal serum sex hormone levels in relation to breast cancer risk, overall and by hormone receptor status-Results from the EPIC cohort.
  • Kaaks R1, Tikk K, Sookthai D, Schock H, Johnson T, Tjønneland A, Olsen A, Overvad K, Clavel-Chapelon F, Dossus L, Baglietto L, Rinaldi S, Chajes V, Romieu I, Boeing H, Schütze M, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Sieri S, Tumino R, Ricceri F, Mattiello A, Buckland G, Ramón Quirós J, Sánchez MJ, Amiano P, Chirlaque MD, Barricarte A, Bas Bueno-de-Mesquita H, van Gils CH, Peeters PH, Andersson A, Sund M, Weiderpass E, Khaw KT, Wareham N, Key TJ, Travis RC, Merritt MA, Gunter MJ, Riboli E, Lukanova A.Author information 1Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.AbstractResults from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (801 breast cancer cases and 1,132 matched control subjects), we analyzed the relationships of prediagnostic serum estradiol, free estradiol, progesterone, testosterone, free testosterone and sex hormone-binding globulin (SHBG) levels with the risk of breast cancer by estrogen and progesterone receptor-positive and -negative breast tumors and by age at diagnoses. Higher prediagnostic serum levels of testosterone and free testosterone were associated with an increased overall risk of breast cancer [ORQ4-Q1  = 1.56 (95% CI 1.15-2.13), ptrend  = 0.02 for testosterone and ORQ4-Q1  = 1.33 (95% CI 0.99-1.79), ptrend  = 0.04 for free testosterone], but no significant risk association was observed for estradiol, free estradiol, progesterone and SHBG. Tests for heterogeneity between receptor-positive and -negative tumors were not significant. When analysis were stratified by age at tumor diagnosis, the odds ratios observed for estradiol were stronger and borderline significant for breast cancer diagnosed at age less than 50 [ORQ4-Q1  = 1.32 (95% CI 0.87-2.01), ptrend  = 0.05] compared to breast cancer diagnosed at age 50 or above [ORQ4-Q1  = 0.94 (95% CI 0.60-1.47), ptrend  = 0.34, phet  = 0.04]. In conclusion, our data indicate that higher premenopausal circulating testosterone levels are associated with an increased risk of developing breast cancer, but do not show a significant association of estradiol or progesterone with breast cancer risk, overall, by menstrual cycle phase or by tumor receptor status, although a possible risk increase with higher estradiol levels for tumors diagnosed before age 50 was seen.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2014 Apr 15;134(8):1947-57. doi: 10.1002/ijc.28528. Epub 2013 Oct 24.
  • Results from prospective studies on premenopausal serum hormone levels in relation to breast cancer risk have been inconclusive, especially with regard to tumor subtypes. Using a case-control study nested within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) coho
  • PMID 24155248
  • Endogenous sex hormones, metabolic syndrome, and diabetes in men and women.
  • Kim C1, Halter JB.Author information 1Department of Medicine, University of Michigan, 2800 Plymouth Road, Building 16, Room 430 W, Ann Arbor, MI, 48109, USA, cathkim@umich.edu.AbstractEndogenous sex hormones predict impairments of glucose regulation. Cross-sectional studies suggest that lower levels of testosterone in men and higher levels in women increase risk of metabolic syndrome and diabetes, whereas lower levels of sex hormone binding globulin in both men and women increase risk of metabolic syndrome and diabetes. In a systematic review, we summarize existing longitudinal studies, which suggest similar patterns. However, these studies are often limited to a single sex steroid measure. Whether these associations are primarily a marker of adiposity, and whether these associations differ between younger eugonadal vs older hypogonadal adults is also uncertain. The impact of exogenous sex steroid therapy may not reflect relationships between sex hormones and impaired glucose regulation that occur without supplementation. Therefore, examination of endogenous sex steroid trajectories and obesity trajectories within individuals might aid our understanding of how sex steroids contribute to glucose regulation.
  • Current cardiology reports.Curr Cardiol Rep.2014 Apr;16(4):467. doi: 10.1007/s11886-014-0467-6.
  • Endogenous sex hormones predict impairments of glucose regulation. Cross-sectional studies suggest that lower levels of testosterone in men and higher levels in women increase risk of metabolic syndrome and diabetes, whereas lower levels of sex hormone binding globulin in both men and women increase
  • PMID 24585109
  • Hypoxia disrupts gene modulation along the brain-pituitary-gonad (BPG)-liver axis.
  • Lu X1, Yu RM2, Murphy MB1, Lau K3, Wu RS4.Author information 1Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China.2School of Environmental and Life Sciences, The University of Newcastle, NSW, Australia.3School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.4School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. Electronic address: rudolfwu@hku.hk.AbstractHypoxia alters sex hormone concentrations leading to reproductive impairment in fish; however the mechanisms underlying these effects remain largely unknown. Using zebrafish (Danio rerio), this study is the first to demonstrate that hypoxia causes endocrine disruption by simultaneously acting on multiple targets along the brain-pituitary-gonadal (BPG)-liver axis in fish. Alterations in the expression of key genes associated with reproductive endocrine pathways in the brain (sGnRH), pituitary (FSHβ and LHβ), gonads (FSH-R, LH-R, HMGR, StAR, CYP19A, CYP11A, CYP11β and 20β-HSD), and liver were correlated with significant reductions of estradiol in females and testosterone in males. Hypoxia also induced sex-specific and tissue-specific changes in the expression of estrogen, androgen, and membrane progestin receptors along the BPG axis, suggesting disruption of the feedback and synchronization of hormone signals. Furthermore, the hypoxia-induced upregulation of hepatic sex hormone-binding globulin suggests an increase in hormone transport and reduced bioavailability in blood, while upregulation of hepatic CYP3A65 and CYP1A in females suggests an increase in estrogen biotransformation and clearance. Given that the regulation of reproductive hormones and the BPG-liver axis are highly conserved, this study provides new insights into the hypoxia-induced endocrine disrupting mechanisms and reproductive impairment in other vertebrates.
  • Ecotoxicology and environmental safety.Ecotoxicol Environ Saf.2014 Apr;102:70-8. doi: 10.1016/j.ecoenv.2014.01.017. Epub 2014 Feb 1.
  • Hypoxia alters sex hormone concentrations leading to reproductive impairment in fish; however the mechanisms underlying these effects remain largely unknown. Using zebrafish (Danio rerio), this study is the first to demonstrate that hypoxia causes endocrine disruption by simultaneously acting on mul
  • PMID 24580824

和文文献

  • Leptin is an independent determinant of bone mineral density in men with type 2 diabetes mellitus.
  • Vasilkova Olga,Mokhort Tatiana,Sharshakova Tamara,Hayashida Naomi,Takamura Noboru
  • Acta Diabetologica 48(4), 291-295, 2011-12
  • … Hemoglobin A(1c), immune-reactive insulin (IRI), serum total testosterone, and sex hormone-binding globulin were also evaluated. …
  • NAID 120003751816
  • Plasma testosterone and sex hormone-binding globulin concentrations and the risk of prostate cancer among Japanese men : A nested case-control study
  • SAWADA Norie,IWASAKI Motoki,INOUE Manami,SASAZUKI Shizuka,YAMAJI Taiki,SHIMAZU Taichi,Shoichiro Tsugane for the Japan Public Health Center-based Prospective Study Group
  • Cancer science 101(12), 2652-2657, 2010-12-10
  • NAID 10027834956

関連リンク

Describes how the sex hormone binding globulin (SHBG) test is used, when a SHBG test is ordered, and what the results of a SHBG test might mean ... A high SHBG level means that it is likely that less free testosterone is ...
Many conditions of mild-to-moderate androgen excess in women, particularly polycystic ovarian syndrome, are associated with low sex hormone-binding globulin (SHBG) levels. Most of these women are also insulin resistant and ...

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★リンクテーブル★
リンク元性ホルモン結合グロブリン」「SHBG」「testosterone-estrogen-binding globulin
関連記事sex」「binding」「hormone」「globulin」「sexed

性ホルモン結合グロブリン」

  [★]

sex hormone-binding globulin, SHBG
testosterone-estrogen-binding globulin


病態と性ホルモン結合グロブリンの産生 (HIM.2312)

SHBG濃度の低下

  • アンドロゲンの存在、肥満、インスリンの存在、ネフローゼ症候群
→相対的にfreeのテストステロンが増加??

SHBG濃度の上昇

→相対的にfreeのテストステロンが減少??


SHBG」

  [★] 性ホルモン結合グロブリン

See Sex hormone-binding globulin
sex hormone-binding globulin


testosterone-estrogen-binding globulin」

  [★] 性ホルモン結合グロブリン

sex hormone-binding globulin


sex」

  [★]

  • n.
coitalcoitioncoituscopulationgenderintercoursesexual intercoursesexualityvenereal

WordNet   license wordnet

「tell the sex (of young chickens)」

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「all of the feelings resulting from the urge to gratify sexual impulses; "he wanted a better sex life"; "the film contained no sex or violence"」
sexual urge

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「either of the two categories (male or female) into which most organisms are divided; "the war between the sexes"」

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉『性』,性別 / 《the~》《形容詞を伴い集合的に》『男性』,『女性』 / 〈U〉(男女(雌雄)間の)相違[の意識] / 〈U〉性に関する事柄(情報) / 〈U〉性交 / 〈ひよこなど〉‘の'性別を見分ける」

WordNet   license wordnet

「the properties that distinguish organisms on the basis of their reproductive roles; "she didn''t want to know the sex of the foetus"」
gender, sexuality


binding」

  [★]

  • n.
  • adj.
  • 結合性の
affinityassociatebindbondbondingcombineconjoinconjugateconjugationconjunctionconnectconnectionconnectiveconnectivitycoupledockengageengagementjoinligatelinkagesymphysialsymphysicunion

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「executed with proper legal authority; "a binding contract"」

WordNet   license wordnet

「the protective covering on the front, back, and spine of a book; "the book had a leather binding"」
book binding, cover, back

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「strip sewn over or along an edge for reinforcement or decoration」

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「the capacity to attract and hold something」

PrepTutorEJDIC   license prepejdic

「義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料」


hormone」

  [★] ホルモン

WordNet   license wordnet

「the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect」
endocrine, internal secretion

PrepTutorEJDIC   license prepejdic

「ホルモン」


globulin」

  [★] グロブリン

WordNet   license wordnet

「a family of proteins found in blood and milk and muscle and in plant seed」

PrepTutorEJDIC   license prepejdic

「グロブリン(動植物組織内の純蛋白(たんぱく)質の総称)」


sexed」

  [★]

WordNet   license wordnet

「having sexual differentiation」

WordNet   license wordnet

「characterized by sexuality; "highly sexed"」




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