severe combined immunodeficient mice

重症複合免疫不全マウス

関

SCID mice、SCID mouse、SCID-hu mice、SCID-hu mouse、severe combined immunodeficient mouse

WordNet

1. very bad in degree or extent; "a severe worldwide depression"; "the house suffered severe damage"
2. unsparing and uncompromising in discipline or judgment; "a parent severe to the pitch of hostility"- H.G.Wells; "a hefty six-footer with a rather severe mien"; "a strict disciplinarian"; "a Spartan upbringing" (同)spartan
3. intensely or extremely bad or unpleasant in degree or quality; "severe pain"; "a severe case of flu"; "a terrible cough"; "under wicked fire from the enemys guns"; "a wicked cough" (同)terrible, wicked
4. join for a common purpose or in a common action; "These forces combined with others"
5. harvester that heads and threshes and cleans grain while moving across the field
6. add together from different sources; "combine resources"
7. set or keep apart; "sever a relationship" (同)break_up
8. the syllable naming the third (mediant) note of any major scale in solmization
9. incapable of developing an immune response following exposure to an antigen; "immunodeficient rodents"

PrepTutorEJDIC

1. (人・法律などが)『厳しい』,厳格な / (態度・表情が)厳粛な,いかめしい / (病気などが)『重い』,危険な / (様式・趣味などが)簡素な,じみな,飾りのない / (人の体に)厳しくこたえる,激しい / (試験などが)難しい,厳しい
2. …'を'『結合する』,合同する / …'を'兼ね備える;(…と)…'を'兼ね合わさせる《+『名』+『with』+『名』》 / …'を'化合させる;(…と)…'を'化合させる《+『名』+『with』+『名』》 / 『結合する』,連合する,合同する / (…と)化合する《+『with』+『名』》 / 連合,合同;(特に)企業合同,政治連合 / (また『combine harvester』)(刈り取りと脱穀が同時にできる)複式収穫機,コンバイン
3. (全体から)…‘を'切断する《+『名』+『from』+『名』》 / (いくつかの部分に)…‘を'分ける《+『名』+『in』(『into』)+『名』》 / 〈関係など〉‘を'断つ / 切れる,分かれる,分裂する
4. ミ(全音階の第3音)

UpToDate Contents

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• 1. 重度複合型免疫不全（SCID）：概要 severe combined immunodeficiency scid an overview
• 2. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
• 3. JAK3欠損を伴う重度複合型免疫不全（SCID） severe combined immunodeficiency scid with jak3 deficiency
• 4. T-B-NK+ SCID：臨床症状、診断、および治療 t b nk scid clinical manifestations diagnosis and treatment
• 5. T-B-NK+ SCID：病因および遺伝学 t b nk scid pathogenesis and genetics

English Journal

• In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts.

• Alameh G, Emptoz-Bonneton A, Rolland de Ravel M, Matera EL, Mappus E, Balaguer P, Rocheblave L, Lomberget T, Dumontet C, Le Borgne M, Pugeat M, Grenot C, Cuilleron CY.
• Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)684-691.
• Synthetic progesterone and 5α/β-pregnane-3,20-dione derivatives were evaluated as in vitro and in vivo modulators of multidrug-resistance (MDR) using two P-gp-expressing human cell lines, the non-steroidogenic K562/R7 erythroleukaemia cells and the steroidogenic NCI-H295R adrenocortical carcinoma
• PMID 30777494

• Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening.

• Sarwono AEY, Mitsuhashi S, Kabir MHB, Shigetomi K, Okada T, Ohsaka F, Otsuguro S, Maenaka K, Igarashi M, Kato K, Ubukata M.
• Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)171-178.
• Inosine 5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppression, antiviral, and antimicrobial therapy. In the pre
• PMID 30451014

• Assessment of Short-Term Engraftment Potential of Ex Vivo Expanded Hematopoietic Stem Cells Using Normal Fetal Mouse in Utero Transplantation Model.

• Zarrabi M, Afzal E, Asghari MH, Ebrahimi M.
• Cell journal. 2019 Oct;21(3)259-267.
• Array In this experimental study, briefly, isolated hUCB-MNCs were cultured in common expansion medium containing stem cell factor, Flt3 ligand and thrombopoietin. The unexpanded and expanded cells were transplanted to the fetal mice on gestational days of 11.5-13.5. After administration of human he
• PMID 31210431

Japanese Journal

• 次世代型ヒト化マウスの開発と創薬研究への応用

• 日本薬理学雑誌 151(4), 160-165, 2018
• NAID 130006655005

• Mechanistic Study of Inhibitory Effects of Metformin and Atorvastatin in Combination on Prostate Cancer Cells <i>in Vitro</i> and <i>in Vivo</i>

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 40(8), 1247-1254, 2017
• NAID 130005876327

• Super SCIDマウスを用いたヒト前立腺肥大症ゼノグラフトモデル (特集 前立腺肥大症・前立腺炎の動物モデル)

• Prostate journal 3(2), 243-247, 2016-10
• NAID 40020989844

Related Links

• severe combined immunodeficient mice - definition of severe ...

se·vere com·bined im·mu·no·de·fi·cient mice (SCID mice), (se-vēr' kŏm-bīnd i-myū'nō-dē-fi'shent mīs), Mice that lack both T and B lymphocytes and ... SCID or Severe Combined ImmunoDeficient mice are considered by many ...

• Adriamycin nephropathy in severe combined immunodeficient ...

SCID (severe combined immunodeficient) mice are homozygous for an autosomal recessive mutation that leads to the absence of lymphocytes and hypogammaglobulinaemia [4], and are found in BALB/c mice. Adriamycin ...

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★リンクテーブル★

リンク元	「SCID mice」「重症複合免疫不全マウス」「SCID-hu mice」「SCID-hu mouse」
関連記事	「combine」「severe」「sever」「mi」「immunodeficient」

「SCID mice」

　　[★] 重症複合免疫不全マウス、SCIDマウス

関

SCID mouse、SCID-hu mice、SCID-hu mouse、severe combined immunodeficient mice、severe combined immunodeficient mouse

「重症複合免疫不全マウス」

　　[★]

英

severe combined immunodeficient mouse、severe combined immunodeficient mice、SCID mouse、SCID mice

関

SCIDマウス

「SCID-hu mice」

　　[★]

;関:SCID mice

関

SCID mice、SCID mouse、SCID-hu mouse、severe combined immunodeficient mice

• SCID mice

「SCID-hu mouse」

　　[★]

;関:SCID mice

関

SCID mice、SCID mouse、SCID-hu mice、severe combined immunodeficient mice

• SCID mice

「combine」

　　[★]

• v.

• 併用する、組み合わせる、結合する、合併する

関

ally、associate、bind、binding、bond、bonding、combination、combined application、complicate、concomitant、concurrent、conjoin、conjugate、conjugation、conjunction、connect、connection、couple、dock、engage、engagement、join、ligate、linkage、merge、merger、symphysial、union

　 　 　 　

「severe」

　　[★]

• adj.

• 重篤な、重症の、重度の、激しい、苛酷な

• 1.

• 厳しい、厳格な。厳密な(⇔mild)。容赦しない、血も涙もない、痛烈な
• ひどい、猛烈な。骨の折れる。過酷な

• 2

• 簡素な、地味な、渋い。厳粛な

関

critically ill、grave、heavily、intense、life-threatening、rampant、serious、seriously、severe disease、severely、strenuous、severeness

　 　 　 　

「sever」

　　[★]

• v.

• 切断する

関

ablate、ablation、amputate、amputation、break、breakage、cleavage、cleave、scission、transection、truncate、truncation

　 　

「mi」

　　[★]

mi-, mio-

• conb form

• より小さい、より少ない。劣った

• ex.

• miosis 縮瞳

？

MI

　 　

「immunodeficient」

　　[★]

• 免疫不全の

関

immune deficiency、immune disorder、immunodeficiency