seryl-tRNA synthetase

セリルtRNA合成酵素、セリルtRNAシンテターゼ

関

serine-tRNA ligase

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• 1. 成人における皮膚筋炎および多発性筋炎の臨床症状 clinical manifestations of dermatomyositis and polymyositis in adults
• 2. 成人における皮膚筋炎および多発性筋炎の初期治療 initial treatment of dermatomyositis and polymyositis in adults
• 3. ヘキソースリン酸側路およびグルタチオン代謝関連疾患 related disorders of the hexose monophosphate shunt and glutathione metabolism
• 4. 炎症性ミオパチーの病因 pathogenesis of inflammatory myopathies
• 5. 皮膚筋炎および多発性筋炎における間質性肺疾患：臨床症状および診断 interstitial lung disease in dermatomyositis and polymyositis clinical manifestations and diagnosis

English Journal

• Human mitochondrial disease-like symptoms caused by a reduced tRNA aminoacylation activity in flies.

• Guitart T, Picchioni D, Piñeyro D, Ribas de Pouplana L.SourceInstitute for Research in Biomedicine (IRB Barcelona), Gene Translation Laboratory, c/Baldiri Reixac 10, Barcelona, 08028, Catalonia, Spain and Catalan Institution for Research and Advanced Studies (ICREA), Pg. Lluís Companys 23, Barcelona, 08010, Catalonia, Spain.
• Nucleic acids research.Nucleic Acids Res.2013 May 15. [Epub ahead of print]
• The translation of genes encoded in the mitochondrial genome requires specific machinery that functions in the organelle. Among the many mutations linked to human disease that affect mitochondrial translation, several are localized to nuclear genes coding for mitochondrial aminoacyl-transfer RNA syn
• PMID 23677612

• Tertiary structure of bacterial selenocysteine tRNA.

• Itoh Y, Sekine SI, Suetsugu S, Yokoyama S.SourceDepartment of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan and Laboratory of Membrane and Cytoskeleton Dynamics, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
• Nucleic acids research.Nucleic Acids Res.2013 May 6. [Epub ahead of print]
• Selenocysteine (Sec) is translationally incorporated into proteins in response to the UGA codon. The tRNA specific to Sec (tRNASec) is first ligated with serine by seryl-tRNA synthetase (SerRS). In the present study, we determined the 3.1 Å crystal structure of the tRNASec from the bacterium Aquife
• PMID 23649835

Japanese Journal

• Two Crystal Structures of Lysyl-tRNA Synthetase from Bacillus stearothermophilus in Complex with Lysyladenylate-Like Compounds : Insights into the Irreversible Formation of the Enzyme-Bound Adenylate of L-Lysine Hydroxamate

• Sakurama Haruko,Takita Teisuke,Mikami Bunzo [他],ITOH Takafumi,YASUKAWA Kiyoshi,INOUYE Kuniyo
• The journal of biochemistry 145(5), 555-563, 2009-05-01
• NAID 10025588705

• セレノシステイン生合成系とその種多様性

• 水谷 隆治,大坂 享史,藤原 俊伸 [他],Shahidzzman M.
• 藥學雜誌 128(7), 989-996, 2008-07-01
• … Sec is the 21st amino acid, because Sec has its tRNA, the codon UGA and those components in its translational machinery. … We purified Sec synthesizing enzymes, such as seryl-tRNA synthetase (SerRS) , Sec synthetase (SecS) and selenophosphate synthetase (SePS). … I described the procedures to prepare Sec tRNA, SerRS, SecS, SePS and [^<75>Se] H_2Se in detail. …
• NAID 110006792628

Related Links

• Transfer RNA and Seryl-tRNA Synthetase - Kenyon College

II: Transfer RNA Transfer RNA is a fairly small molecule, consisting of 75-90 nucleotides, which folds over itself (via hydrogen bonding between base pairs at four different sites), forming a three-dimensional L-shaped structure. The double ...

• OMIM Entry - * 612804 - SERYL-tRNA SYNTHETASE 2; SARS2

SARS2, ASP390GLY In an infant boy, born of nonconsanguineous Palestinian parents, with HUPRA syndrome (613845), Belostotsky et al. (2011) identified a homozygous ...

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★リンクテーブル★

リンク元	「セリルtRNA合成酵素」「セリルtRNAシンテターゼ」「serine-tRNA ligase」
関連記事	「synthetase」「tRNA」「tRNAs」

「セリルtRNA合成酵素」

　　[★]

英

seryl-tRNA synthetase

関

セリンtRNAリガーゼ、セリルtRNAシンテターゼ

「セリルtRNAシンテターゼ」

　　[★]

英

seryl-tRNA synthetase

関

セリルtRNA合成酵素

「serine-tRNA ligase」

　　[★]

セリンtRNAリガーゼ

関

seryl-tRNA synthetase

「synthetase」

　　[★]

• n.

• (ATPやNADを必要とする2分子連結酵素リガーゼの別名)シンテターゼ、シンセターゼ、連結酵素、合成酵素

関

ligase、synthase

「tRNA」

　　[★] トランスファーRNA, transfer RNA, 転位RNA

「tRNAs」

　　[★] トランスファーRNA transfer RNAs