血清テストステロン

WordNet

an amber, watery fluid, rich in proteins, that separates out when blood coagulates (同)blood_serum
a potent androgenic hormone produced chiefly by the testes; responsible for the development of male secondary sex characteristics

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リンパ液 / 血清
serial / series / sermon

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1. 副腎アンドロゲンの測定 measurement of adrenal androgens
2. 高齢男性におけるテストステロン欠乏症の概要 overview of testosterone deficiency in elderly men
3. 性腺機能低下を呈する男性の臨床的特徴および診断 clinical features and diagnosis of male hypogonadism
4. 性腺機能低下を呈する男性に対するテストステロン治療 testosterone treatment of male hypogonadism
5. 男性生殖生理学 male reproductive physiology

English Journal

Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen.

Tassinari R, Cubadda F, Moracci G, Aureli F, D'Amato M, Valeri M, De Berardis B, Raggi A, Mantovani A, Passeri D, Rossi M, Maranghi F.Author information Istituto Superiore di Sanità , Rome , Italy.AbstractThe study explored possible reproductive and endocrine effects of short-term (5 days) oral exposure to anatase TiO2 nanoparticles (0, 1, 2 mg/kg body weight per day) in rat. Nanoparticles were characterised by scanning electron microscopy (SEM) and transmission electron microscopy, and their presence in spleen, a target organ for bioaccumulation, was investigated by single-particle inductively coupled plasma mass spectrometry and SEM/energy-dispersive X-ray. Analyses included serum hormone levels (testosterone, 17-β-estradiol and triiodothyronine) and histopathology of thyroid, adrenals, ovary, uterus, testis and spleen. Increased total Ti tissue levels were found in spleen and ovaries. Sex-related histological alterations were observed at both dose levels in thyroid, adrenal medulla, adrenal cortex (females) and ovarian granulosa, without general toxicity. Altered thyroid function was indicated by reduced T3 (males). Testosterone levels increased in high-dose males and decreased in females. In the spleen of treated animals TiO2 aggregates and increased white pulp (high-dose females) were detected, even though Ti tissue levels remained low reflecting the low doses and the short exposure time. Our findings prompt to comprehensively assess endocrine and reproductive effects in the safety evaluation of nanomaterials.
Nanotoxicology.Nanotoxicology.2014 Sep;8(6):654-62. doi: 10.3109/17435390.2013.822114. Epub 2013 Jul 25.
The study explored possible reproductive and endocrine effects of short-term (5 days) oral exposure to anatase TiO2 nanoparticles (0, 1, 2 mg/kg body weight per day) in rat. Nanoparticles were characterised by scanning electron microscopy (SEM) and transmission electron microscopy, and their presenc
PMID 23834344

In Vivo Deletion of CAR Resulted in High Bone Mass Phenotypes in Male Mice.

Cho HY, Jung JY, Park H, Yang JY, Jung S, An JH, Cho SW, Kim SW, Kim SY, Kim JE, Park YJ, Shin CS.Author information Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.AbstractConstitutive androstane receptor (CAR) was originally identified as xenobiotic sensor that regulates the expression of cytochrome P450 genes. However, recent studies suggest that this nuclear receptor is also involved in the regulation of energy metabolism including glucose and lipid homeostasis. This study investigated the role of CAR in the regulation of bone mass in vivo using CAR(-/-) mice. Endogenous mRNA expression of CAR was observed in both primary osteoblasts and osteoclast precursors. CAR(-/-) mice have exhibited significant increase in whole body bone mineral density (BMD) by 9.5% (P < 0.01) and 5.5% (P < 0.05) at 10 and 15 weeks of age, respectively, compared with WT mice in males. Microcomputed tomography analysis of proximal tibia demonstrated a significant increase in trabecular bone volume (62.7%), trabecular number (54.1%) in male CAR(-/-) mice compared with WT mice. However, primary culture of calvarial cells exhibited no significant changes in osteogenic differentiation potential between CAR(-/-) and WT. In addition, the number of tartrate-resistant acid-phosphatase positive osteoclasts in the femur and serum level of CTx was not different between CAR(-/-) and WT mice. The higher BMD and microstructural parameters were not observed in female mice. Interestingly, serum level of testosterone in male CAR(-/-) mice was 2.5-fold higher compared with WT mice and the mRNA expressions of Cyp2b9 and 2b10 in the liver, which regulate testosterone metabolism, were significantly down-regulated in male CAR(-/-) mice. Furthermore, the difference in BMD between CAR(-/-) and WT mice disappeared at 8 weeks after performing orchiectomy. CAR(-/-) mice also exhibited significant increase in serum 1,25(OH)2 D3 levels but Cyp 27B1 which converts 25(OH)D3 to 1,25(OH)2 D3 was significantly down-regulated compared to WT mice. These results suggest that in vivo deletion of CAR resulted in higher bone mass, which appears to be a result from reduced metabolism of testosterone due to down-regulation of Cyp2b. J. Cell. Physiol. 229: 561-571, 2014. © 2013 Wiley Periodicals, Inc.
Journal of cellular physiology.J Cell Physiol.2014 May;229(5):561-71. doi: 10.1002/jcp.24478.
Constitutive androstane receptor (CAR) was originally identified as xenobiotic sensor that regulates the expression of cytochrome P450 genes. However, recent studies suggest that this nuclear receptor is also involved in the regulation of energy metabolism including glucose and lipid homeostasis. Th
PMID 24114688

The role of orlistat combined with lifestyle changes in the management of overweight and obese patients with polycystic ovary syndrome.

Panidis D, Tziomalos K, Papadakis E, Chatzis P, Kandaraki EA, Tsourdi EA, Katsikis I.Author information Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece.AbstractOBJECTIVE: Obesity is frequently present in women with the polycystic ovary syndrome (PCOS) and aggravates insulin resistance (IR) and hyperandrogenemia. We aimed to assess the effects of orlistat combined with lifestyle changes in overweight and obese women with PCOS and body mass index (BMI)-matched controls.
Clinical endocrinology.Clin Endocrinol (Oxf).2014 Mar;80(3):432-8. doi: 10.1111/cen.12305. Epub 2013 Aug 28.
OBJECTIVE: Obesity is frequently present in women with the polycystic ovary syndrome (PCOS) and aggravates insulin resistance (IR) and hyperandrogenemia. We aimed to assess the effects of orlistat combined with lifestyle changes in overweight and obese women with PCOS and body mass index (BMI)-match
PMID 23909452

Japanese Journal

α遮断薬投与中の前立腺肥大症患者に対するデュタステリド追加投与の効果 : 特に過活動膀胱の改善について

和田直樹,橋爪和純,玉木岳
泌尿器科紀要 58(9), 475-480, 2012-09
… We investigated the add-on effect of dutasteride (0.5 mg once a day) on lower urinary tract symptoms (LUTS), prostate volume (PV), and serum prostate specific antigen (PSA) and testosterone level in 72 patients with benign prostatic hyperplasia (BPH) who had been treated with alpha-blocker monotherapy. … At the baseline, 12 and 24 weeks after dutasteride add-on, we assessed IPSS, overactive bladder symptom score (OABSS), PV, serum PSA and testosterone. …
NAID 40019429478

2型糖尿病を伴う閉経後女性の性ホルモン,性ホルモン結合蛋白とメタボリックシンドロームの関連

熊谷秋三,古賀五月,岸本裕歩
健康科学 34, 9-14, 2012
… Results: Free and total testosterone levels in type2 DM with MS had significantly increased as compared with non-SM. … On the other hand, the SHBG level in type2 DM with MS had significantly decreased as compared with non-MS. Independently of VFA evaluated by CT scan, we observed that diastolic blood pressure at resting was significantly associated with calculated free testosterone, dehydroepiandrosterone-sufate and SHBG, and that serum triglyceride was significantly associated with SHBG. …
NAID 40019302551

Sex Differences in the Associations of Testosterone and Sex Hormone-Binding Globulin With Metabolic Syndrome in Middle-Aged and Elderly Koreans:–

Kweon Sun-Seog,Shin Min-Ho,Nam Hae-Sung,Jeong Seul-Ki,Park Kyeong-Soo,Choi Jin-Su,Lee Young-Hoon
Circulation Journal, 2012
… Background: We investigated the sex-dependent associations of testosterone and sex hormone-binding globulin (SHBG) levels with metabolic syndrome (MetS). … Serum total testosterone (TT) and SHBG levels were determined using a chemiluminescent microparticle immunoassay, and free testosterone (FT) concentrations were calculated. … These results suggest sex differences in the associations of endogenous testosterone and SHBG with MetS. …
NAID 130002491330