serotonin reuptake inhibitor

• セロトニン再取り込み阻害薬、セロトニン再取り込み抑制薬、セロトニン再取り込み阻害剤、セロトニン再取り込み抑制剤

関

5-HT uptake inhibitor、serotonin uptake inhibitor

WordNet

1. an antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain (同)SSRI
2. limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
3. control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
4. limit the range or extent of; "Contact between the young was inhibited by strict social customs"
5. a substance that retards or stops an activity
6. a process of using up or consuming again; "psychopharmacologists discovered that amine reuptake is a process that inactivates monoamine neurotransmitters" (同)re-uptake
7. a neurotransmitter involved in e.g. sleep and depression and memory (同)5-hydroxytryptamine

PrepTutorEJDIC

1. 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
2. 抑制する人(物) / 化学反応抑制剤

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/16 15:39:12」(JST)

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[Wiki en表示]

This article is about serotonin reuptake inhibitors. For SSRIs, see selective serotonin reuptake inhibitor.

Serotonin

A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) by blocking the action of the serotonin transporter (SERT). This in turn leads to increased extracellular concentrations of serotonin and, therefore, an increase in serotonergic neurotransmission.

SRIs are not synonymous with selective serotonin reuptake inhibitors (SSRIs), as the latter term is usually used to describe the class of antidepressants of the same name, and because SRIs, unlike SSRIs, can either be selective or non-selective in their action. For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI.

SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders. Less often, SRIs are also used to treat a variety of other medical conditions including neuropathic pain and fibromyalgia (e.g., duloxetine, milnacipran), and premature ejaculation (e.g., dapoxetine) as well as for dieting (e.g., sibutramine). Additionally, some clinically used drugs such as chlorpheniramine, dextromethorphan, and methadone possess SRI properties secondarily to their primary mechanism of action(s) and this contributes to their side effect and drug interaction profiles.

List of SRIs

Many SRIs exist, an assortment of which are listed below. Note that only SRIs selective for the SERT over the other monoamine transporters (MATs) are listed below. For a list of SRIs that act at multiple MATs, see other monoamine reuptake inhibitor pages such as SNRI and SNDRI.

• Selective serotonin reuptake inhibitors (SSRIs)
  • Alaproclate (GEA-654)
  • Citalopram (Celexa)
  • Dapoxetine (Priligy)
  • Escitalopram (Lexapro, Cipralex)
  • Femoxetine (Malexil)
  • Fluoxetine (Prozac)
  • Fluvoxamine (Luvox)
  • Ifoxetine (CGP-15,210-G)
  • Indalpine (Upstene)
  • Omiloxetine
  • Panuramine (WY-26,002)
  • Paroxetine (Paxil, Seroxat)
  • Pirandamine (AY-23,713)
  • RTI-353
  • Sertraline (Zoloft, Lustral)
  • Zimelidine (Normud, Zelmid)

• Active metabolites of SSRIs
  • Desmethylcitalopram
  • Didesmethylcitalopram
  • Seproxetine ((S)-norfluoxetine)

• Combined SRIs and serotonin receptor ligands
  • Cianopramine (Ro 11-2465)
  • Litoxetine (SL-810,385)
  • Lubazodone (YM-992, YM-35,995)
  • SB-649,915
  • Trazodone (Desyrel)
  • Vilazodone (Viibryd)
  • Vortioxetine (Brintellix)

• Drugs with SRI actions as weaker and/or unintended secondary effects
  • Dextromethorphan (DXM; Robitussin)
  • Dextropropoxyphene (Darvon)
  • Dimenhydrinate (Dramamine)
  • Diphenhydramine (Benadryl)
  • Mepyramine (pyrilamine) (Anthisan)
  • Mifepristone (Korlym, Mifeprex)

• Other SRIs
  • Delucemine (also an NMDA antagonist)
  • Mesembrenone (also a weak PDE4 inhibitor (found in Sceletium tortuosum (kanna))
  • Mesembrine (also a weak PDE4 inhibitor (found in Sceletium tortuosum (kanna))
  • Roxindole (EMD-49,980) (also a 5-HT_1A and D₂-like receptor agonist)

See also

• Monoamine reuptake inhibitor

References

UpToDate Contents

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• 1. 選択的セロトニン再取り込み阻害剤：薬理学、投与方法、および副作用 selective serotonin reuptake inhibitors pharmacology administration and side effects
• 2. 選択的セロトニン再取り込み阻害剤中毒 selective serotonin reuptake inhibitor poisoning
• 3. 選択的セロトニン再取り込み阻害剤（SSRI）関連の性機能不全：マネージメント sexual dysfunction associated with selective serotonin reuptake inhibitor ssri antidepressants management
• 4. Infants with antenatal exposure to selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs)
• 5. 成人における単一恐怖に対する薬物療法 pharmacotherapy for specific phobia in adults

English Journal

• Rate of improvement during and across three treatments for panic disorder with or without agoraphobia: Cognitive behavioral therapy, selective serotonin reuptake inhibitor or both combined.

• Van Apeldoorn FJ, Van Hout WJ, Timmerman ME, Mersch PP, den Boer JA.SourceUniversity Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands. Electronic address: f.j.van.apeldoorn@umcg.nl.
• Journal of affective disorders.J Affect Disord.2013 Sep 5;150(2):313-9. doi: 10.1016/j.jad.2013.04.012. Epub 2013 May 12.
• BACKGROUND: Existing literature on panic disorder (PD) yields no data regarding the differential rates of improvement during Cognitive Behavioral Therapy (CBT), Selective Serotonin Reuptake Inhibitor (SSRI) or both combined (CBT+SSRI).METHOD: Patients were randomized to CBT, SSRI or CBT+SSRI which e
• PMID 23676529

• Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: Implications for underlying fear circuits.

• Burghardt NS, Bauer EP.SourceColumbia University, Departments of Neuroscience and Psychiatry, 1051 Riverside Drive, Unit 87, New York, NY 10032, United States; The New York State Psychiatric Institute, Division of Integrative Neuroscience, New York, NY 10032, United States. Electronic address: nsb2113@columbia.edu.
• Neuroscience.Neuroscience.2013 Sep 5;247:253-72. doi: 10.1016/j.neuroscience.2013.05.050. Epub 2013 Jun 1.
• Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of a spectrum of anxiety disorders, yet paradoxically they may increase symptoms of anxiety when treatment is first initiated. Despite extensive research over the past 30years focused on SSRI treatment, the precise mec
• PMID 23732229

• Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice.

• Espinera AR, Ogle ME, Gu X, Wei L.SourceDepartment of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, United States.
• Neuroscience.Neuroscience.2013 Sep 5;247:1-11. doi: 10.1016/j.neuroscience.2013.04.011. Epub 2013 Apr 13.
• Recent clinical trials have demonstrated that treatment with selective serotonin reuptake inhibitors after stroke enhances motor functional recovery; however, the underlying mechanisms remain to be further elucidated. We hypothesized that daily administration of the clinical drug citalopram would pr
• PMID 23590907

Japanese Journal

• 臨床経験 Escitalopramが有用であった自己臭症の1例

• 精神科治療学 30(9), 1259-1265, 2015-09
• NAID 40020647753

• SSRIと認知行動療法の併用療法が奏効した強迫性障害を主たる病態とした特定不能の摂食障害の1例

• 心身医学 55(5), 432-438, 2015-05-01
• NAID 110009943634

• Milnacipran Remediates Impulsive Deficits in Rats with Lesions of the Ventromedial Prefrontal Cortex

• International journal of neuropsychopharmacology 18(5), 2015-03
• NAID 120005613575

Related Links

• Serotonin reuptake inhibitor - Wikipedia, the free encyclopedia

A serotonin reuptake inhibitor (SRI) is a type of drug that acts as a reuptake inhibitor for the neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) by blocking the action of the serotonin transporter (SERT). This in turn leads to increased ...

• Selective serotonin reuptake inhibitor - Wikipedia, the free ...

Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor ( SSRIs) are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders. SSRIs are ...

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★リンクテーブル★

リンク元	「セロトニン再取り込み阻害剤」「セロトニン再取り込み阻害薬」「serotonin uptake inhibitor」「セロトニン再取り込み抑制剤」「セロトニン再取り込み抑制薬」
拡張検索	「selective serotonin reuptake inhibitors」「serotonin reuptake inhibitors」「selective serotonin reuptake inhibitor」
関連記事	「inhibit」「inhibitor」「serotonin」

「セロトニン再取り込み阻害剤」

　　[★]

英

serotonin reuptake inhibitor

関

セロトニン再取り込み阻害薬、セロトニン取り込み阻害剤、セロトニン取り込み抑制薬、セロトニン再取り込み抑制薬、セロトニン再取り込み抑制剤

「セロトニン再取り込み阻害薬」

　　[★]

英

serotonin reuptake inhibitor

関

セロトニン取り込み阻害剤、セロトニン取り込み抑制薬、セロトニン再取り込み阻害剤、セロトニン再取り込み抑制薬、セロトニン再取り込み抑制剤

「serotonin uptake inhibitor」

　　[★]

• セロトニン取り込み阻害薬、セロトニン取り込み抑制薬、セロトニン取り込み阻害剤、セロトニン取り込み抑制剤

関

5-HT uptake inhibitor、serotonin reuptake inhibitor

「セロトニン再取り込み抑制剤」

　　[★]

英

serotonin reuptake inhibitor

関

セロトニン再取り込み阻害薬、セロトニン再取り込み阻害剤、セロトニン再取り込み抑制薬

「セロトニン再取り込み抑制薬」

　　[★]

英

serotonin reuptake inhibitor

関

セロトニン再取り込み阻害薬、セロトニン再取り込み阻害剤、セロトニン再取り込み抑制剤

「selective serotonin reuptake inhibitors」

　　[★]

同

SSRIs

同

SSRIs

関

SSRIs

同

SSRIs

「serotonin reuptake inhibitors」

　　[★]

同

SSRIs

関

Selective serotonin reuptake inhibitors

「selective serotonin reuptake inhibitor」

　　[★] 選択的セロトニン再取り込み阻害薬 SSRI

「inhibit」

　　[★]

• v.

• 抑制する、阻害する、阻止する

関

abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression

　 　 　 　

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「serotonin」

　　[★] セロトニン 5-HT 5HT