serotonin receptor antagonist

セロトニン受容体拮抗薬

WordNet

1. a drug that neutralizes or counteracts the effects of another drug
2. a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
3. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
4. a neurotransmitter involved in e.g. sleep and depression and memory (同)5-hydroxytryptamine

PrepTutorEJDIC

1. 対立する人,敵対者,競争相手(opponent)
2. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/18 16:16:53」(JST)

wiki en

[Wiki en表示]

A serotonin antagonist is a drug used to inhibit the action at serotonin (5-HT) receptors.

Types

5-HT_2A antagonists

Antagonists of the 5-HT_2A receptor are sometimes used as atypical antipsychotics (contrast with typical antipsychotics, which are purely dopamine antagonists). They include:

• Clozapine blocks 5-HT_2A, 5-HT_2C and D₄ receptors.
• Cyproheptadine blocks 5-HT_2A, HI and is a mild anticholinergic.
• Ketanserin blocks 5-HT_2A, 5-HT_2C and Alpha 1 (A1) adrenoreceptors.
• Methysergide is a 5-HT_2A antagonist and nonselective 5-HT₁ receptor blocker. It causes retroperitoneal fibrosis and mediastinal fibrosis.
• Quetiapine blocks 5-HT_2A, 5-HT_1A, dopamine receptors D₁ and D₂, histamine receptor H1, and A1 adrenoreceptors.

5-HT₃ antagonists

Another subclass consists of drugs selectively acting at the 5-HT₃ receptors, and thus are known as 5-HT₃ antagonists. They are efficacious in treating chemotherapy-induced emesis. They include:

• Dolasetron
• Granisetron
• Ondansetron
• Palonosetron
• Tropisetron

Other 5-HT₃ antagonists are used for the treatment of irritable bowel syndrome:

• Alosetron
• Cilansetron

Others

• Pizotifen is a 5-HT_2C antagonist, H1 blocker and anticholinergic useful in migraine prophylaxis.
• Feverfew is a herb traditionally used for migraines.

See also

• Serotonin receptor agonist

References

External links

• Serotonin Antagonists at the US National Library of Medicine Medical Subject Headings (MeSH)
• MeSH list of agents 82012702

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 制吐剤の特性 characteristics of antiemetic drugs
• 2. セロトニンモジュレータ：薬理学、投与、および副作用 serotonin modulators pharmacology administration and side effects
• 3. セロトニン症候群 serotonin syndrome
• 4. 麻酔後ケア病棟における合併症発生の概要 overview of complications occurring in the post anesthesia care unit
• 5. 癌における食欲不振および悪液質の薬理学的マネージメント pharmacologic management of cancer anorexia cachexia

English Journal

• Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats.

• Avila-Rojas SH1, Velázquez-Lagunas I1, Salinas-Abarca AB1, Barragán-Iglesias P1, Pineda-Farias JB1, Granados-Soto V2.
• Brain research.Brain Res.2015 Oct 5;1622:377-85. doi: 10.1016/j.brainres.2015.06.043. Epub 2015 Jul 10.
• Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT receptors. The role of 5-HT5A receptor in neuropathic pain has not previously studied. The purpose of this study was to investigate: A) the role of 5-HT5A receptors in rats subjected to spinal nerve injury; B) the ex
• PMID 26168890

• Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice.

• Hasebe S1, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, Matsuda T.
• Behavioural pharmacology.Behav Pharmacol.2015 Oct;26(7 Spec No):681-90. doi: 10.1097/FBP.0000000000000140.
• We have recently found that isolation-reared mice show hyperactivity during an encounter with an intruder. However, it is not known whether encounter-induced hyperactivity may model some aspects of psychiatric disorders. The present study examined the pharmacological profile of encounter-induced hyp
• PMID 25932719

• 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy.

• Navari RM1.
• Biochimica et biophysica acta.Biochim Biophys Acta.2015 Oct;1848(10 Pt B):2738-2746. doi: 10.1016/j.bbamem.2015.03.020. Epub 2015 Mar 30.
• Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life. The emetogenicity of the chemotherapeutic agents, repeated chemotherapy cycles, and patient risk factors significantly influence CINV. The use of a combination of a 5-hydroxytryptamine-
• PMID 25838122

Japanese Journal

• Effect of the coadministration of citalopram with mirtazapine or atipamezole on rat contextual conditioned fear

• Masuda Takahiro,Inoue Takeshi,An Yan,Takamura Naoki,Nakagawa Shin,Kitaichi Yuji,Koyama Tsukasa,Kusumi Ichiro
• Neuropsychiatric disease and treatment 10, 289-295, 2014-02-11
• … The addition of mirtazapine to selective serotonin reuptake inhibitors (SSRIs) is clinically suggested to be more effective for anxiety disorders. … Because mirtazapine blocks alpha(2)-adrenoreceptors, the combined effect of atipamezole, a selective alpha(2) receptor antagonist, with citalopram was also examined. …
• NAID 120005411141

• Industrial Info. 統合失調症治療薬

• 廣瀬 毅
• 細胞 45(3), 132-136, 2013-03
• NAID 40019691702

• Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT2A and 5-HT3 receptors

• Iwasaki Takeyuki,Otsuguro Ken-ichi,Kobayashi Takeshi,Ohta Toshio,Ito Shigeo
• European Journal of Pharmacology 702(1-3), 149-157, 2013-02-28
• … Serotonin (5-HT) released from descending fibers plays important roles in spinal functions such as locomotion and nociception. … The pCA-mediated inhibition was reversed by ketanserin (a 5-HT2A receptor antagonist) and tropisetron (a 5-HT3 receptor antagonist). …
• NAID 120005228705

Related Links

• Serotonin (5-HT): receptors, agonists and antagonists | CME ...

Serotonin receptors characteristics, classification and drugs that influence serotonergic transmission. Pharmacology review. ... Serotonin (5-hydroxytryptamine, 5-HT) is a key mediator in the physiology of mood, vascular function and ...

• SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS - Search ...

Introduction The serotonin type 3 (5-HT3) receptor antagonists are potent antiemetics used for prevention of postsurgical or chemotherapy induced nausea and vomiting and for some agents as therapy of diarrhea ...

---

★リンクテーブル★

リンク元	「セロトニン受容体拮抗薬」
関連記事	「serotonin receptor」「serotonin」

「セロトニン受容体拮抗薬」

　　[★]

英

serotonin receptor antagonist

関

セロトニン受容体

「serotonin receptor」

　　[★]

• セロトニン受容体、セロトニンレセプター

関

5-HT receptor、5-HT1A receptor、5-HT1A serotonin receptor、5-HT1B receptor、5-HT2A receptor、5-HT2C receptor、5-HT3 receptor

「serotonin」

　　[★] セロトニン 5-HT 5HT