secosteroid

セコステロイド

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/02 10:47:04」(JST)

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Cholecalciferol (vitamin D₃)

Ergocalciferol (vitamin D₂)

Steroid skeleton. Note how the "B" ring is broken in vitamin D.

A secosteroid is a molecule similar to a steroid but with a "broken" ring. The word is from Latin: sec "to cut", - Latin: stere "solid, three dimensional", - oid, from Ancient Greek: ειδος, eidos "form".

Secosteroids are very similar in structure to steroids except that two of the B-ring carbon atoms (C9 and 10) of the typical four steroid rings are not joined, whereas in steroids they are.

In humans, a well known secosteroid is vitamin D.

References

Bibliography

Ayers, Donald (1972). Bioscientific Terminology. Tucson: University of Arizona Press. ISBN 978-0-8165-0305-6. 

External links

• Secosteroids at the US National Library of Medicine Medical Subject Headings (MeSH)

English Journal

• Aplysiasecosterol A: A 9,11-Secosteroid with an Unprecedented Tricyclic γ-Diketone Structure from the Sea Hare Aplysia kurodai.

• Kawamura A1, Kita M2, Kigoshi H3.
• Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2015 Jun 8;54(24):7073-6. doi: 10.1002/anie.201501749. Epub 2015 Apr 29.
• A new 9,11-secosteroid having an unprecedented tricyclic γ-diketone structure, aplysiasecosterol A (1), was isolated from the sea hare Aplysia kurodai. The structure was determined by one- and two-dimensional NMR spectroscopic analysis, molecular modeling studies, a comparison of experimental and
• PMID 25925956

• Vitamin D attenuates cytokine-induced remodeling in human fetal airway smooth muscle cells.

• Britt RD Jr1, Faksh A, Vogel ER, Thompson MA, Chu V, Pandya HC, Amrani Y, Martin RJ, Pabelick CM, Prakash YS.
• Journal of cellular physiology.J Cell Physiol.2015 Jun;230(6):1189-98. doi: 10.1002/jcp.24814.
• Asthma in the pediatric population remains a significant contributor to morbidity and increasing healthcare costs. Vitamin D3 insufficiency and deficiency have been associated with development of asthma. Recent studies in models of adult airway diseases suggest that the bioactive Vitamin D3 metaboli
• PMID 25204635

• 9,11-Secosteroids with cytotoxic activity from the South China Sea gorgonian coral Subergorgia suberosa.

• Zhang J1, Liu LL2, Zhong BL3, Liao XJ4, Xu SH5.
• Steroids.Steroids.2015 Jun;98:100-6. doi: 10.1016/j.steroids.2015.03.004. Epub 2015 Mar 18.
• Nine new 9,11-secosterols (1-9), containing the same 3β,6α,11-trihydroxy-9,11-seco-5α-cholest-7-en-9-one steroidal nucleus, whereas possessing an array of structurally diverse side chains, along with fourteen known 9,11-secosterol compounds (10-23), were isolated from the South China Sea gorgonia
• PMID 25796549

Japanese Journal

• Aplysiasecosterols B and C: two new 9,11-secosteroids with a cis-fused 1,4-quinone structure from the sea hare Aplysia kurodai

• Tetrahedron letters 57(8), 858-860, 2016-02
• NAID 120005741423

• Haebaruol, a 9,11-Secosteroid Isolated from the Soft Coral <i>Clavularia</i> sp.

• Chemistry Letters 45(1), 81-82, 2016
• NAID 130005118762

• Haebaruol, a 9, 11-secosteroid isolated from the soft coral <i>Clavularia</i> sp.

• Chemistry Letters advpub(0), 2016
• NAID 130005108744

Related Links

• secosteroid - definition of secosteroid by Medical dictionary

Reversing deficiency and maintaining optimal serum vitamin D levels beneficially impacts biochemistry and numerous body systems; this is largely because calcitriol—the metabolic product of vitamin D—is a secosteroid hormone that ...

• secosteroid - Definition - Mondofacto

secosteroid definition from the mondofacto online medical dictionary ... Bookmark with: word visualiser Go and visit our forums

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