出典: meddic

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「any pathological hardening or thickening of tissue」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/29 17:23:14」(JST)

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  • Innate immunity in systemic sclerosis pathogenesis.
  • O'Reilly S.Source*Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2014 Mar 1;126(5):329-37. doi: 10.1042/CS20130367.
  • The innate immune system is a critical part of the response to pathogens and overall immunity. Compared with the adaptive immune response, these innate responses are not antigen-specific and recognize patterns in bacteria, viruses and fungi. Chief among these are TLRs (Toll-like receptors). TLRs are
  • PMID 24219159
  • Pharmacogenomics of interferon beta and glatiramer acetate response: A review of the literature.
  • Mahurkar S, Suppiah V, O'Doherty C.SourceSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
  • Autoimmunity reviews.Autoimmun Rev.2014 Feb;13(2):178-86. doi: 10.1016/j.autrev.2013.10.012. Epub 2013 Nov 2.
  • Multiple sclerosis (MS) is one of the most common inflammatory and degenerative autoimmune diseases of the central nervous system with considerable heterogeneity in all aspects, including response to therapy. A number of disease modifying drugs, including traditional first line agents such as, inter
  • PMID 24189284
  • Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature.
  • Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Cailleux AF, Weber J, Lagoutte P, Benichou J, Levesque H.SourceDepartment of Internal Medicine, CHU Rouen, Rouen, France; INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France. Electronic address:
  • Autoimmunity reviews.Autoimmun Rev.2014 Feb;13(2):151-6. doi: 10.1016/j.autrev.2013.10.002. Epub 2013 Oct 12.
  • INTRODUCTION: Systemic sclerosis (SSc) has complex pathogenesis and likely multifactorial causes. Environmental exposures have been suggested to play a role in SSc pathogenesis, including occupational exposure to pollutants and chemicals as well as use of drugs leading to modulation of immune respon
  • PMID 24129037


  • 免疫(3)自己免疫疾患の最近の知見〜新しく改訂された分類基準についての概説〜
  • 勝又 康弘
  • 東京女子医科大学雑誌 85(3), 73-80, 2015-06-25
  • … RA)分類基準、Systemic Lupus International Collaborating Clinics (SLICC)による2012年全身性エリテマトーデス(systemic lupus erythematosus;SLE)分類基準、ACR/EULARによる2013年全身性強皮症(systemic sclerosis; …
  • NAID 110009915562
  • Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration
  • Sekiya Tetsuji,Holley Matthew C.,Hashido Kento,Ono Kazuya,Shimomura Koichiro,Horie Rie T.,Hamaguchi Kiyomi,Yoshida Atsuhiro,Sakamoto Tatsunori,Ito Juichi
  • Proceedings of the National Academy of Sciences, 2015-06-15
  • … 2015-06-16.Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders, including spinal cord injury, Parkinson's disease, and amyotrophic lateral sclerosis. …
  • NAID 120005615649
  • 腸内細菌による多発性硬化症の制御 (第1土曜特集 粘膜免疫Update) -- (粘膜免疫と疾患)


sclerosis [sklĕ-ro´sis] an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the ...
sclerosis scle·ro·sis (sklə-rō'sĭs) n. pl. scle·ro·ses (-sēz) The hardening of a tissue or part due to chronic inflammation. A thickening or hardening of a body part or system especially from excessive formation of fibrous interstitial or ...


Description Systemic sclerosis finger.jpgTuberous sclerosis. Causes, symptoms File:TuberousSclerosis-Rayer-ColourSmall Tuberous Sclerosis Photo - Skin Disease Tuberous Sclerosis is not contagious and Tuberous Sclerosis Photo - Skin Disease

拡張検索large artery atherosclerosis」「atherosclerosis」「Balo concentric sclerosis」「multiple sclerosis」「mesenteric phlebosclerosis



  • adj.
  • 硬化する

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「make hard or harder; "The cold hardened the butter"」

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「〈物〉‘を'『堅くする』,固める / 〈人・心〉‘を'『がんこ(悲情)にする』,かたくなにする;〈人〉‘を'(…に)無感覚にする《+『名』〈人〉+『to』+『名』(do『ing』)》 / 〈体など〉‘を'強くする,鍛練する / 〈信念・信仰など〉‘を'強固にする / 〈物が〉堅くなる,固まる / 〈人・心が〉かたくなになる,がんこになる / 〈体が〉強くなる / 〈信念・信仰などが〉強固になる,固まる」

WordNet   license wordnet

「become hard or harder; "The wax hardened"」



  • n.

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「the process of becoming hard or solid by cooling or drying or crystallization; "the hardening of concrete"; "he tested the set of the glue"」
solidifying, solidification, set, curing

WordNet   license wordnet

「abnormal hardening or thickening of tissue」

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「the act of making something harder (firmer or tighter or more compact)」




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「the process of becoming stiff or rigid」
rigidifying, rigidification

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「the act of becoming stiff; "stiffening his shoulders, he prepared to advance"」



  • n.




large artery atherosclerosis」

  [★] 大血管アテローム硬化、大血管動脈硬化、主幹動脈動脈硬化、LAA

[show details]


  [★] アテローム性動脈硬化粥状硬化症

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「a stage of arteriosclerosis involving fatty deposits (atheromas) inside the arterial walls, thus narrowing the arteries」
coronary artery disease

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Balo concentric sclerosis」

  [★] バロー同心円硬化症

multiple sclerosis」

  [★] 多発性硬化症 MS

mesenteric phlebosclerosis」

  [★] 腸間膜静脈硬化症