出典: meddic

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「any pathological hardening or thickening of tissue」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/29 17:23:14」(JST)

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  • Innate immunity in systemic sclerosis pathogenesis.
  • O'Reilly S.Source*Musculoskeletal Research Group, Institute of Cellular Medicine, 4th Floor Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2014 Mar 1;126(5):329-37. doi: 10.1042/CS20130367.
  • The innate immune system is a critical part of the response to pathogens and overall immunity. Compared with the adaptive immune response, these innate responses are not antigen-specific and recognize patterns in bacteria, viruses and fungi. Chief among these are TLRs (Toll-like receptors). TLRs are
  • PMID 24219159
  • Pharmacogenomics of interferon beta and glatiramer acetate response: A review of the literature.
  • Mahurkar S, Suppiah V, O'Doherty C.SourceSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
  • Autoimmunity reviews.Autoimmun Rev.2014 Feb;13(2):178-86. doi: 10.1016/j.autrev.2013.10.012. Epub 2013 Nov 2.
  • Multiple sclerosis (MS) is one of the most common inflammatory and degenerative autoimmune diseases of the central nervous system with considerable heterogeneity in all aspects, including response to therapy. A number of disease modifying drugs, including traditional first line agents such as, inter
  • PMID 24189284
  • Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature.
  • Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Cailleux AF, Weber J, Lagoutte P, Benichou J, Levesque H.SourceDepartment of Internal Medicine, CHU Rouen, Rouen, France; INSERM U 905, University of Rouen IFRMP, Institute for Biochemical Research, Rouen, France. Electronic address:
  • Autoimmunity reviews.Autoimmun Rev.2014 Feb;13(2):151-6. doi: 10.1016/j.autrev.2013.10.002. Epub 2013 Oct 12.
  • INTRODUCTION: Systemic sclerosis (SSc) has complex pathogenesis and likely multifactorial causes. Environmental exposures have been suggested to play a role in SSc pathogenesis, including occupational exposure to pollutants and chemicals as well as use of drugs leading to modulation of immune respon
  • PMID 24129037


  • 免疫(3)自己免疫疾患の最近の知見〜新しく改訂された分類基準についての概説〜
  • 勝又 康弘
  • 東京女子医科大学雑誌 85(3), 73-80, 2015-06-25
  • … RA)分類基準、Systemic Lupus International Collaborating Clinics (SLICC)による2012年全身性エリテマトーデス(systemic lupus erythematosus;SLE)分類基準、ACR/EULARによる2013年全身性強皮症(systemic sclerosis; …
  • NAID 110009915562
  • Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration
  • Sekiya Tetsuji,Holley Matthew C.,Hashido Kento,Ono Kazuya,Shimomura Koichiro,Horie Rie T.,Hamaguchi Kiyomi,Yoshida Atsuhiro,Sakamoto Tatsunori,Ito Juichi
  • Proceedings of the National Academy of Sciences, 2015-06-15
  • … 2015-06-16.Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders, including spinal cord injury, Parkinson's disease, and amyotrophic lateral sclerosis. …
  • NAID 120005615649
  • 腸内細菌による多発性硬化症の制御 (第1土曜特集 粘膜免疫Update) -- (粘膜免疫と疾患)


sclerosis [sklĕ-ro´sis] an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the ...
sclerosis scle·ro·sis (sklə-rō'sĭs) n. pl. scle·ro·ses (-sēz) The hardening of a tissue or part due to chronic inflammation. A thickening or hardening of a body part or system especially from excessive formation of fibrous interstitial or ...


Description Systemic sclerosis finger.jpgTuberous sclerosis. Causes, symptoms File:TuberousSclerosis-Rayer-ColourSmall Tuberous Sclerosis Photo - Skin Disease Tuberous Sclerosis is not contagious and Tuberous Sclerosis Photo - Skin Disease

拡張検索atherosclerosis of saphenous vein graft」「amyotrophic lateral sclerosis」「relapsing-remitting multiple sclerosis」「tuberous sclerosis



  • adj.
  • 硬化する

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「make hard or harder; "The cold hardened the butter"」

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「〈物〉‘を'『堅くする』,固める / 〈人・心〉‘を'『がんこ(悲情)にする』,かたくなにする;〈人〉‘を'(…に)無感覚にする《+『名』〈人〉+『to』+『名』(do『ing』)》 / 〈体など〉‘を'強くする,鍛練する / 〈信念・信仰など〉‘を'強固にする / 〈物が〉堅くなる,固まる / 〈人・心が〉かたくなになる,がんこになる / 〈体が〉強くなる / 〈信念・信仰などが〉強固になる,固まる」

WordNet   license wordnet

「become hard or harder; "The wax hardened"」



  • n.

WordNet   license wordnet

「the process of becoming hard or solid by cooling or drying or crystallization; "the hardening of concrete"; "he tested the set of the glue"」
solidifying, solidification, set, curing

WordNet   license wordnet

「abnormal hardening or thickening of tissue」

WordNet   license wordnet

「the act of making something harder (firmer or tighter or more compact)」




WordNet   license wordnet

「the process of becoming stiff or rigid」
rigidifying, rigidification

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「the act of becoming stiff; "stiffening his shoulders, he prepared to advance"」

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  • n.




atherosclerosis of saphenous vein graft」

  [★] アテローム性移植伏在静脈硬化症

amyotrophic lateral sclerosis」

  [★] 筋萎縮性側索硬化症 ALS

relapsing-remitting multiple sclerosis」



tuberous sclerosis」

  [★] 結節性硬化症 TS