Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/18 19:14:42」(JST)

wiki en

Peripheral blood (MGG stain): patient with hemolytic-uremic syndrome

A schistocyte or schizocyte (from Greek schistos for "divided" or schistein for "to split", and kytos for "hollow" or "cell") is a fragmented part of a red blood cell. Schistocytes are typically irregularly shaped, jagged, and have two pointed ends. A true schistocyte does not have central pallor. ^[1] Schistocytes are sometimes referred to as "helmet cells".

Several microangiopathic diseases, including disseminated intravascular coagulation and thrombotic microangiopathies, generate fibrin strands that sever red blood cells as they try to move past a thrombus, creating schistocytes.

Schistocytes are often seen in patients with hemolytic anemia. They are frequently a consequence of mechanical artificial heart valves and hemolytic uremic syndrome, among other causes.

Excessive schistocytes present in blood can be a sign of microangiopathic hemolytic anemia (MAHA) where the most common cause is aortic stenosis.

References[edit source | edit]

^ Amanda Cox et al., Schistocytes: A Brief Overview. Retrieved 23 August 2008.

External links[edit source | edit]

Images in Clinical Medicine: Hemolytic Anemia after Mitral-Valve Repair, Sarinya Puwanant and Watchara Lohawijarn, N Engl J Med 2012; 367:e29 (November 15, 2012) DOI: 10.1056/NEJMicm1201695 [FREE TEXT]

This article related to pathology is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. マラリアの発症機序pathogenesis of malaria [show details]
…many 1000-fold until mature tissue schizonts are formed, each containing thousands of daughter merozoites. This exoerythrocytic stage is asymptomatic. The liver schizonts rupture after 6 to 30 days; 98 percent …
2. 非熱帯熱マラリア：二日熱マラリア原虫non falciparum malaria plasmodium knowlesi [show details]
…the liver, where they invade hepatocytes, undergo asexual replication, and develop into schizonts. Hepatic schizonts rupture and release thousands of daughter merozoites into the bloodstream, causing fever …
3. マラリアにおける貧血anemia in malaria [show details]
…ingests and degrades hemoglobin and develops through the stages of rings, trophozoites and schizonts. Mature schizonts burst to release merozoites which invade new red cells. A small proportion of merozoites…
4. 旅行者におけるマラリア感染の予防prevention of malaria infection in travelers [show details]
…Primaquine has activity against many stages of the malaria parasite including hypnozoites, tissue schizonts, gametocytes, and asexual blood stages of P. vivax . It is useful for preventing relapses from …
5. 異常ヘモグロビン症におけるマラリアに対する防御protection against malaria in the hemoglobinopathies [show details]
…the first growth cycle but a markedly reduced number of ring forms following the schizont stage, with degenerated schizonts observed on day 4. This defect was not affected by deoxygenation or an increase …

English Journal

Third-party mesenchymal stromal cell infusion is associated with a decrease in thrombotic microangiopathy symptoms observed post-hematopoietic stem cell transplantation.

Ansari M1, Strunk D, Schallmoser K, Delcò C, Rougemont AL, Moll S, Villard J, Gumy-Pause F, Chalandon Y, Parvex P, Passweg J, Ozsahin H, Kindler V.
Pediatric transplantation.Pediatr Transplant.2012 Mar;16(2):131-6. doi: 10.1111/j.1399-3046.2011.01621.x. Epub 2011 Dec 7.
TA-TMA is a pathology that occurs after allogenic HSC transplantation with an incidence of 4-13%, and represents one of the most severe vascular damage related with this therapy. We report here the case of a nine-yr-old girl suffering from a severe refractory aplastic anemia who received an unrelate
PMID 22151234

Evaluation of point-of-care tests for diagnosis of disseminated intravascular coagulation in dogs admitted to an intensive care unit.

Bateman SW1, Mathews KA, Abrams-Ogg AC, Lumsden JH, Johnstone IB, Hillers TK.
Journal of the American Veterinary Medical Association.J Am Vet Med Assoc.1999 Sep 15;215(6):805-10.
OBJECTIVE: To evaluate the accuracy of point-of-care tests for the diagnosis of disseminated intravascular coagulation (DIC) in dogs and assess the correlation and agreement of results between point-of-care and laboratory tests in the evaluation of hemostatic function.DESIGN: Prospective case series
PMID 10496132

Japanese Journal

臨床研究・症例報告重度の溶血性貧血と多種な破砕赤血球を認めた腸管出血性大腸菌O157:H7感染症の1例

小児科臨床 68(8), 1547-1550, 2015-08
NAID 40020527953

高齢者の播種性血管内凝固症候群における赤血球の形態学的変化と血小板粒度

日本老年医学会雑誌 33(11), 847-851, 1996-11-25
NAID 10013852290

Related Pictures

Schistocyte/ Schizocyte/ Fragmentocyte | Fragmented RBS due to rupture in the Schistocytes = mechanical red cell fragmentation = MAHA (DIC, TTP, HUS, HELLP) and Cytologie des anémies IFBLS e-Learning Hematology Hemolytic-uremic syndrome - Wikipedia