関: salivary gland cancer

WordNet

any of various organs that synthesize substances needed by the body and release it through ducts or directly into the bloodstream (同)secretory organ, secretor, secreter
a clear liquid secreted into the mouth by the salivary glands and mucous glands of the mouth; moistens the mouth and starts the digestion of starches (同)spit, spittle
of or relating to saliva; "salivary gland"

PrepTutorEJDIC

(生物体内の)腺(せん)
だ液,つば
(体内にできる)新生物;腫瘍(しゅよう)
だ液の;だ液を分泌する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/07 17:24:59」(JST)

wiki en

Salivary gland cancer is a cancer that forms in tissues of a salivary gland. The salivary glands are classified as major and minor. The major salivary glands consist of the parotid, submandibular, and sublingual glands. The minor glands include small mucus-secreting glands located throughout the palate, nasal and oral cavity.^[1] Salivary gland cancer is rare, with 2% of head and neck tumors forming in the salivary glands, the majority in the parotid.^[2]

Classification

Benign tumor of the submandibular gland, also known as pleomorphic adenoma, presented as a painless neck mass in a 40-year-old man. At the left of the image is the white tumor with its characteristic cartilaginous cut surface. To the right is the normally lobated submandibular salivary gland.

Salivary gland neoplasms are classified by the World Health Organization as primary or secondary, benign or malignant, and by tissue of origin.^[3] This system defines five broad categories of salivary gland neoplasms:^[4]

malignant epithelial tumors (e.g. acinic cell carcinoma, mucoepidermoid carcinoma and adenoid cystic carcinoma, salivary duct carcinoma)
benign epithelial tumors (e.g. pleomorphic adenoma, myoepithelioma and Warthin tumour, sebaceous lymphadenoma)
soft tissue tumors (Hemangioma)
hematolymphoid tumors (e.g. Hodgkin lymphoma)
secondary tumors.

Signs and symptoms

Signs include fluid draining from the ear, pain, numbness, weakness, trouble swallowing, and a lump. The most common symptom of major salivary gland cancer is a painless lump in the affected gland, sometimes accompanied by paralysis of the facial nerve.

Causes

The chief risk factor is chewing tobacco, followed by smoking. Other risk factors include older age, radiation therapy treatment to head or neck, and being exposed to certain carcinogenic substances at work.

Pathogenesis

Diagnosis

In most cases, local excision with a margin of normal tissue is the appropriate form of biopsy for a major salivary gland tumor. In the parotid region, this requires identification of the facial nerve. For submandibular tumors, the entire submandibular triangle is cleared. In contrast, minor salivary gland tumors have a higher likelihood of being malignant, and an incisional biopsy is performed initially so that definitive treatment can be planned. In the parotid region, the presence of pain, recent rapid enlargement of a preexisting nodule, skin involvement, or facial nerve paralysis suggests cancer. Enlarged cervical lymph nodes in association with a salivary gland tumor are considered a manifestation of cancer until proved otherwise. Fine-needle aspiration is indicated if accurate diagnosis will allow for better treatment planning.

Prevention

Treatment

Treatment may include the following:

Surgery with or without radiation.
Radiation therapy.
Chemotherapy.

Surgery

Radiotherapy

Fast neutron therapy has been used successfully to treat salivary gland tumors,^[5] and has shown to be significantly more effective than photons in studies treating unresectable salivary gland tumors.^[6]^[7]

Chemotherapy

Prognosis

Epidemiology

History

Notes

^ Shah, p. 240
^ Harari, p. 89
^ IARC, p. 210
^ IARC, p. 210
^ Douglas JD, Koh WJ , Austin-Seymour, M, Laramore GE. Treatment of Salivary Gland Neoplasms with fast neutron Radiotherapy. Arch Otolaryngol Head Neck Surg Vol 129 944-948 Sep 2003
^ Laramore GE, Krall JM, Griffin TW, Duncan W, Richter MP, Saroja KR, Maor MH, Davis LW. Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an RTOG-MRC randomized clinical trial. Int J Radiat Oncol Biol Phys. 1993 Sep 30;27(2):235-40.
^ Krüll A, Schwarz R, Engenhart R, et al.: European results in neutron therapy of malignant salivary gland tumors. Bull Cancer Radiother 83 (Suppl): 125-9s, 1996

References

Harari, Paul (2009). Functional Preservation and Quality of Life in Head and Neck Radiotherapy. Springer.
"Tumors of the Salivary Glands" (PDF). International Agency for Research on Cancer. Retrieved 2009-07-30.
Shah, Jatin (2001). Atlas of Clinical Oncology: Cancer of the Head and Neck. BC Decker Inc.

External links

Salivary gland cancer entry in the public domain NCI Dictionary of Cancer Terms
The Patients Forum on Tumors Of The Parotid Gland
Clinically reviewed salivary gland cancer for patients from Cancer Research UK.

This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

UpToDate Contents

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1. 唾液腺腫瘍：疫学、診断、評価、および病期分類 salivary gland tumors epidemiology diagnosis evaluation and staging
2. 唾液腺腫瘍：限局性疾患の治療 salivary gland tumors treatment of locoregional disease
3. 悪性唾液腺腫瘍：再発性および転移性疾患の治療 malignant salivary gland tumors treatment of recurrent and metastatic disease
4. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
5. 唾石症 salivary gland stones

English Journal

A pediatric case of mammary analogue secretory carcinoma within the parotid.

Quattlebaum SC1, Roby B1, Dishop MK2, Said MS2, Chan K3.
American journal of otolaryngology.Am J Otolaryngol.2015 Nov-Dec;36(6):741-3. doi: 10.1016/j.amjoto.2015.05.005. Epub 2015 Jun 1.
Mammary analogue secretory carcinoma (MASC) is a recently described entity in the differential diagnosis of salivary gland tumors. It is notable for a characteristic t(12;15)(p13;q25) translocation that results in a unique fusion protein, ETV6-NTRK3. While several studies have retrospectively identi
PMID 26545463

High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors.

Nikolic N1, Anicic B2, Carkic J1, Simonovic J1, Toljic B1, Tanic N3, Tepavcevic Z4, Vukadinovic M2, Konstantinovic VS2, Milasin J5.
Archives of oral biology.Arch Oral Biol.2015 Nov;60(11):1662-6. doi: 10.1016/j.archoralbio.2015.08.011. Epub 2015 Aug 22.
OBJECTIVES: to investigate p16(INK4a) and p14(ARF) tumor suppressor gene methylation status, determine telomere length and assess the importance of these epigenetic and genetic parameters in the development of pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid salivary glands.MA
PMID 26351750

Salivary gland myoepithelial carcinoma.

Vilar-González S1, Bradley K2, Rico-Pérez J3, Vogiatzis P2, Golka D4, Nigam A4, Sivaramalingam M3, Kazmi S4.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.Clin Transl Oncol.2015 Nov;17(11):847-55. doi: 10.1007/s12094-015-1329-4. Epub 2015 Jul 2.
Salivary gland myoepithelial carcinoma (MC) or malignant myoepithelioma is a rare entity. MC usually presents as a slow-growing painless mass arising in the parotid gland, but may involve other salivary glands. This tumour may be particularly locally aggressive, but its clinical and biological featu
PMID 26133522

Japanese Journal

気管支原発の腺房細胞癌の1症例

安藤耕平,渡部克也,植草利公,伊藤俊輔,佐藤千春,黒崎裕一郎,平居義裕
気管支学 : 日本気管支研究会雑誌 34(5), 437-441, 2012-09-25
背景.腺房細胞癌は漿液性腺房細胞への分化を示す悪性腫瘍であり,ほとんどは唾液腺,そのうちの多くは耳下腺から発生する.気管支・肺を原発とする腺房細胞癌の報告は極めて稀であり,英文での報告を含めても現在までに17症例報告されているのみであった.症例. 55歳男性.他疾患の精査中に胸部X線異常を指摘された. CTで右S^4bに20mm大の境界明瞭な結節を認めた.気管支鏡検査で右B^4bを閉塞する腫瘤性病 …
NAID 110009518307

A Case of Adenoid Cystic Carcinoma Presenting as Garcin's Syndrome without Mass Formation

Inose Yuri,Kobayashi Masaki,Hiroi Atsuko,Toi Sono,Maruyama Kenji,Shimizu Yuko,Shibata Noriyuki,Yoshihara Toshio,Uchiyama Shinichiro
Internal Medicine 51(1), 87-91, 2012
… Adenoid cystic carcinoma (ACC) is a malignant neoplasm that commonly arises in the major or minor salivary gland and usually forms mass lesions. … Right submaxillary gland biopsy after repeated challenges at last revealed the primary focus of ACC with perineural invasion and without lymph node metastasis. …
NAID 130002062417

顎下腺に生じた上皮筋上皮癌と肺癌の重複癌の1例

櫻井博理,吉田孝史,尾崎尚,濱本宜興,飯野光喜,小林孝憲,朔敬
日本口腔腫瘍学会誌 24(1), 29-34, 2012
上皮筋上皮癌は，全唾液腺腫瘍の1%を占めるまれな唾液腺悪性腫瘍である。その大部分は耳下腺に好発する。今回われわれは，顎下腺に生じた上皮筋上皮癌と，肺癌の重複癌の1例を経験したので報告する。患者は57歳の女性。約10年前からの左顎下部の腫脹を主訴に当科を受診した。左顎下腺部に拇指頭大の弾性硬の腫瘤を触知した。CTにて，左顎下腺体内ならびに左上葉肺野に腫瘍性病変を認めた。左顎下腺腫瘍と左転移性肺癌の診 …
NAID 130001668649

Related Pictures

★リンクテーブル★

リンク元	「唾液腺腫瘍」「salivary gland cancer」「唾液腺新生物」
関連記事	「neoplasm」「salivary」

「唾液腺腫瘍」

Salivary gland cancer
	Classification and external resources
	; The major salivary glands: the Parotid gland (1), where most salivary gland tumors form, the Submandibular gland (2), and the Sublingual gland (3).
ICD-10	C07-C08, D11
ICD-9	142, 210.2
MedlinePlus	001040
MeSH	D012468

　　[★]

英: salivary gland neoplasm, salivary gland tumor, tumor of salivary gland, sialoma
関: 唾液腺癌、唾液腺新生物、唾液腺、耳下腺腫瘍

「salivary gland cancer」

　　[★]

唾液腺癌、唾液腺がん

関: salivary gland neoplasm

「唾液腺新生物」

　　[★]

英: salivary gland neoplasm
関: 唾液腺腫瘍

「neoplasm」

　　[★]

n.

新生物、腫瘍

関: benign neoplasm、cancer、neoplasia、neoplastic、onco、oncologic、tumor、tumour

「salivary」

　　[★]

唾液の

関: saliva

[1] Shah, p. 240

[2] Harari, p. 89

[3] IARC, p. 210

[4] IARC, p. 210

[5] Douglas JD, Koh WJ , Austin-Seymour, M, Laramore GE. Treatment of Salivary Gland Neoplasms with fast neutron Radiotherapy. Arch Otolaryngol Head Neck Surg Vol 129 944-948 Sep 2003

[6] Laramore GE, Krall JM, Griffin TW, Duncan W, Richter MP, Saroja KR, Maor MH, Davis LW. Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an RTOG-MRC randomized clinical trial. Int J Radiat Oncol Biol Phys. 1993 Sep 30;27(2):235-40.

[7] Krüll A, Schwarz R, Engenhart R, et al.: European results in neutron therapy of malignant salivary gland tumors. Bull Cancer Radiother 83 (Suppl): 125-9s, 1996

匿名

検索

案内

案内

salivary gland neoplasm