関: salivary gland neoplasm

WordNet

type genus of the family Cancridae (同)genus Cancer
the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 (同)Cancer the Crab, Crab
(astrology) a person who is born while the sun is in Cancer (同)Crab
a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream (同)malignant neoplastic disease
any of various organs that synthesize substances needed by the body and release it through ducts or directly into the bloodstream (同)secretory organ, secretor, secreter
a clear liquid secreted into the mouth by the salivary glands and mucous glands of the mouth; moistens the mouth and starts the digestion of starches (同)spit, spittle
of or relating to saliva; "salivary gland"

PrepTutorEJDIC

〈U〉〈C〉『がん』 / 〈U〉〈C〉害悪 / 《Cancer》(星座の)カニ座
(生物体内の)腺(せん)
だ液,つば
だ液の;だ液を分泌する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/19 19:40:37」(JST)

wiki en

Salivary gland cancer is a cancer that forms in tissues of a salivary gland. The salivary glands are classified as major and minor. The major salivary glands consist of the parotid, submandibular, and sublingual glands. The minor glands include small mucus-secreting glands located throughout the palate, nasal and oral cavity.^[1] Salivary gland cancer is rare, with 2% of head and neck tumors forming in the salivary glands, the majority in the parotid.^[2]

Classification

Benign tumor of the submandibular gland, also known as pleomorphic adenoma, presented as a painless neck mass in a 40-year-old man. At the left of the image is the white tumor with its characteristic cartilaginous cut surface. To the right is the normally lobated submandibular salivary gland.

Salivary gland neoplasms are classified by the World Health Organization as primary or secondary, benign or malignant, and by tissue of origin.^[3] This system defines five broad categories of salivary gland neoplasms:^[4]

malignant epithelial tumors (e.g. acinic cell carcinoma, mucoepidermoid carcinoma and adenoid cystic carcinoma, salivary duct carcinoma)
benign epithelial tumors (e.g. pleomorphic adenoma, myoepithelioma and Warthin tumour, sebaceous lymphadenoma)
soft tissue tumors (Hemangioma)
hematolymphoid tumors (e.g. Hodgkin lymphoma)
secondary tumors.

Signs and symptoms

Signs include fluid draining from the ear, pain, numbness, weakness, trouble swallowing, and a lump. The most common symptom of major salivary gland cancer is a painless lump in the affected gland, sometimes accompanied by paralysis of the facial nerve.

Causes

The chief risk factor is chewing tobacco, followed by smoking. Other risk factors include older age, radiation therapy treatment to head or neck, and being exposed to certain carcinogenic substances at work.

Pathogenesis

Diagnosis

In most cases, local excision with a margin of normal tissue is the appropriate form of biopsy for a major salivary gland tumor. In the parotid region, this requires identification of the facial nerve. For submandibular tumors, the entire submandibular triangle is cleared. In contrast, minor salivary gland tumors have a higher likelihood of being malignant, and an incisional biopsy is performed initially so that definitive treatment can be planned. In the parotid region, the presence of pain, recent rapid enlargement of a preexisting nodule, skin involvement, or facial nerve paralysis suggests cancer. Enlarged cervical lymph nodes in association with a salivary gland tumor are considered a manifestation of cancer until proved otherwise. Fine-needle aspiration is indicated if accurate diagnosis will allow for better treatment planning.

Prevention

Treatment

Treatment may include the following:

Surgery with or without radiation.
Radiation therapy.
Chemotherapy.

Surgery

Radiotherapy

Fast neutron therapy has been used successfully to treat salivary gland tumors,^[5] and has shown to be significantly more effective than photons in studies treating unresectable salivary gland tumors.^[6]^[7]

Chemotherapy

Prognosis

Epidemiology

History

Notes

^ Shah, p. 240
^ Harari, p. 89
^ IARC, p. 210
^ IARC, p. 210
^ Douglas JD, Koh WJ , Austin-Seymour, M, Laramore GE. Treatment of Salivary Gland Neoplasms with fast neutron Radiotherapy. Arch Otolaryngol Head Neck Surg Vol 129 944-948 Sep 2003
^ Laramore GE, Krall JM, Griffin TW, Duncan W, Richter MP, Saroja KR, Maor MH, Davis LW. Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an RTOG-MRC randomized clinical trial. Int J Radiat Oncol Biol Phys. 1993 Sep 30;27(2):235-40.
^ Krüll A, Schwarz R, Engenhart R, et al.: European results in neutron therapy of malignant salivary gland tumors. Bull Cancer Radiother 83 (Suppl): 125-9s, 1996

References

Harari, Paul (2009). Functional Preservation and Quality of Life in Head and Neck Radiotherapy. Springer.
"Tumors of the Salivary Glands" (PDF). International Agency for Research on Cancer. Retrieved 2009-07-30.
Shah, Jatin (2001). Atlas of Clinical Oncology: Cancer of the Head and Neck. BC Decker Inc.

External links

Salivary gland cancer entry in the public domain NCI Dictionary of Cancer Terms
The Patients Forum on Tumors Of The Parotid Gland
Clinically reviewed salivary gland cancer for patients from Cancer Research UK.

This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

UpToDate Contents

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1. 悪性唾液腺腫瘍：再発性および転移性疾患の治療 malignant salivary gland tumors treatment of recurrent and metastatic disease
2. 唾液腺腫瘍：疫学、診断、評価、および病期分類 salivary gland tumors epidemiology diagnosis evaluation and staging
3. 唾液腺腫瘍：限局性疾患の治療 salivary gland tumors treatment of locoregional disease
4. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
5. 頭頸部癌に対する治療の概要 overview of treatment for head and neck cancer

English Journal

Value of SOX10 Immunostaining in Tumor Diagnosis.

Ordóñez NG.SourceDepartment of Pathology, M.D. Anderson Cancer Center, The University of Texas, Houston, TX.
Advances in anatomic pathology.Adv Anat Pathol.2013 Jul;20(4):275-83. doi: 10.1097/PAP.0b013e318297a9d0.
SOX10 is a transcription factor that is essential for the generation of neural crest cells, their survival, and maintenance of pluripotency. Recent studies have shown that, among tumors, SOX10 is commonly expressed in melanomas, including desmoplastic melanomas, tumors with Schwann cell differentiat
PMID 23752089

Diagnostic accuracy of fine needle aspiration cytology for high-grade salivary gland tumors.

Kim BY, Hyeon J, Ryu G, Choi N, Baek CH, Ko YH, Jeong HS.SourceDepartment of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Annals of surgical oncology.Ann Surg Oncol.2013 Jul;20(7):2380-7. doi: 10.1245/s10434-013-2903-z. Epub 2013 Feb 26.
BACKGROUND: Preoperative differentiation between high-grade malignancy and others (benign or low-grade tumors) is more important than differentiation between malignant and benign tumors for surgical planning, treatment outcome, and prognosis in salivary gland tumors. Fine needle aspiration cytology
PMID 23440550

Cause-specific mortality in patients with mucoepidermoid carcinoma of the major salivary glands.

Ali S, Sarhan M, Palmer FL, Whitcher M, Shah JP, Patel SG, Ganly I.SourceDepartment of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Annals of surgical oncology.Ann Surg Oncol.2013 Jul;20(7):2396-404. doi: 10.1245/s10434-013-2872-2. Epub 2013 Feb 9.
BACKGROUND: The objective of this study was to determine the incidence and cause of disease-specific death in patients with mucoepidermoid carcinoma (MEC) affecting the major salivary glands.METHODS: A total of 94 patients with MEC treated at Memorial Sloan-Kettering Cancer Center between 1985 and 2
PMID 23397152

Japanese Journal

全身多発転移をきたした副耳下腺由来のリンパ上皮癌の1例

頭頸部癌 41(1), 69-73, 2015
NAID 130005070004

A Case of Cystadenoma Arising in the Upper Lip

The Bulletin of Tokyo Dental College 56(1), 49-55, 2015
NAID 130004868709

遠隔転移を有する頭頸部癌の原発巣に対する姑息的照射

頭頸部癌 40(4), 473-478, 2014
NAID 130004940789

Related Pictures

★リンクテーブル★

リンク元	「唾液腺癌」「salivary gland neoplasm」「唾液腺がん」
関連記事	「cancer」「salivary」

「唾液腺癌」

Salivary gland cancer
	Classification and external resources
	The major salivary glands: the parotid gland (1), where most salivary gland tumors form, the submandibular gland (2), and the sublingual gland (3).
ICD-10	C07-C08, D11
ICD-9	142, 210.2
MedlinePlus	001040
MeSH	D012468

　　[★]

英: salivary gland cancer
関: 唾液腺がん、唾液腺腫瘍

「salivary gland neoplasm」

　　[★]

唾液腺腫瘍、唾液腺新生物

関: salivary gland cancer

「唾液腺がん」

　　[★]

英: salivary gland cancer
関: 唾液腺癌

「cancer」

　　[★]

同: 癌腫
関: tumor

「salivary」

　　[★]

唾液の

関: saliva

[1] Shah, p. 240

[2] Harari, p. 89

[3] IARC, p. 210

[4] IARC, p. 210

[5] Douglas JD, Koh WJ , Austin-Seymour, M, Laramore GE. Treatment of Salivary Gland Neoplasms with fast neutron Radiotherapy. Arch Otolaryngol Head Neck Surg Vol 129 944-948 Sep 2003

[6] Laramore GE, Krall JM, Griffin TW, Duncan W, Richter MP, Saroja KR, Maor MH, Davis LW. Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an RTOG-MRC randomized clinical trial. Int J Radiat Oncol Biol Phys. 1993 Sep 30;27(2):235-40.

[7] Krüll A, Schwarz R, Engenhart R, et al.: European results in neutron therapy of malignant salivary gland tumors. Bull Cancer Radiother 83 (Suppl): 125-9s, 1996

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案内

案内

salivary gland cancer