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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/29 13:15:59」(JST)
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Ryanodine
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Identifiers |
CAS Registry Number
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15662-33-6 Y |
ChEBI |
CHEBI:8925 Y |
ChEMBL |
ChEMBL612231 N |
ChemSpider |
16736002 Y |
InChI
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InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1 Y
Key: JJSYXNQGLHBRRK-SFEDZAPPSA-N Y
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InChI=1/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1
Key: JJSYXNQGLHBRRK-SFEDZAPPBA
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IUPHAR/BPS
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4303 |
Jmol-3D images |
Image |
KEGG |
C08705 N |
MeSH |
Ryanodine |
PubChem |
5114 |
SMILES
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C[C@H]1CC[C@@]2([C@@]3(C[C@]4([C@@]5([C@]([C@H]([C@@]3([C@]5([C@]2([C@@H]1O)O4)O)O)OC(=O)c6ccc[nH]6)(C(C)C)O)C)O)C)O
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Properties |
Chemical formula
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C25H35NO9 |
Molar mass |
493.547 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is: Y/N?) |
Infobox references |
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Ryanodine is a poisonous alkaloid found in the South American plant Ryania speciosa (Salicaceae). It was originally used as an insecticide.
The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.
At nanomolar concentrations, ryanodine locks the receptor in a half-open state, whereas it fully closes them at micromolar concentration. The effect of the nanomolar-level binding is that ryanodine causes release of calcium from calcium stores as the sarcoplasmic reticulum in the cytoplasm, leading to massive muscular contractions. The effect of micromolar-level binding is paralysis. This is true for both mammals and insects.
See also
- Ryanoid, a class of insecticides with the same mechanism of action as ryanodine
References
- Bertil Hille, Ionic Channels of Excitable Membranes, 2nd edition, Sinauer Associates, Sunderland, MA, 01375, ISBN 0-87893-323-9
UpToDate Contents
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English Journal
- Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness.
- Yamada T1, Fedotovskaya O2, Cheng AJ2, Cornachione AS3, Minozzo FC3, Aulin C4, Fridén C5, Turesson C6, Andersson DC7, Glenmark B8, Lundberg IE4, Rassier DE3, Westerblad H2, Lanner JT2.
- Annals of the rheumatic diseases.Ann Rheum Dis.2015 Oct;74(10):1907-14. doi: 10.1136/annrheumdis-2013-205007. Epub 2014 May 22.
- OBJECTIVE: Skeletal muscle weakness is a prominent clinical feature in patients with rheumatoid arthritis (RA), but the underlying mechanism(s) is unknown. Here we investigate the mechanisms behind arthritis-induced skeletal muscle weakness with special focus on the role of nitrosative stress on int
- PMID 24854355
- Coupling acidic organelles with the ER through Ca(2+) microdomains at membrane contact sites.
- Penny CJ1, Kilpatrick BS1, Eden ER2, Patel S3.
- Cell calcium.Cell Calcium.2015 Oct;58(4):387-96. doi: 10.1016/j.ceca.2015.03.006. Epub 2015 Mar 23.
- Acidic organelles such as lysosomes serve as non-canonical Ca(2+) stores. The Ca(2+) mobilising messenger NAADP is thought to trigger local Ca(2+) release from such stores. These events are then amplified by Ca(2+) channels on canonical ER Ca(2+) stores to generate physiologically relevant global Ca
- PMID 25866010
- Role of Ryanodine and NMDA Receptors in Tetrabromobisphenol A-Induced Calcium Imbalance and Cytotoxicity in Primary Cultures of Rat Cerebellar Granule Cells.
- Zieminska E1, Stafiej A, Toczylowska B, Albrecht J, Lazarewicz JW.
- Neurotoxicity research.Neurotox Res.2015 Oct;28(3):195-208. doi: 10.1007/s12640-015-9546-8. Epub 2015 Jul 28.
- The study assessed the role of ryanodine receptors (RyRs) and NMDA receptors (NMDARs) in the Ca(2+) transients and cytotoxicity induced in neurons by the brominated flame retardant tetrabromobisphenol A (TBBPA). Primary cultures of rat cerebellar granule cells (CGC) were exposed to 7.5, 10, or 25 �
- PMID 26215658
Japanese Journal
- 小胞体カルシウムチャネルファミリーの作動原理 : 共通性と特異性
- 悪性高熱症におけるリアノジン受容体機能的変異の同定 (第129回成医会総会一般演題)
- 山澤 德志子,村山 尚,小山田 英人,飯野 正光,竹森 重
- 東京慈恵会医科大学雑誌 127(6), 248-248, 2012-11-15
- NAID 120005104567
Related Links
- Buy Ryanodine (CAS 15662-33-6), a potent modulator of Ryanodine receptor activity, from Santa Cruz. Purity >96%, Molecular Formula C25H35NO9, MW 493.5 ... Ryanodine is a complex alkaloid natural product and prototypic ...
- View and buy high purity Ryanodine from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... The technical data provided above is for guidance only. For batch specific data refer to the ...
★リンクテーブル★
[★]
- 関
- ryanodine receptor 1、RyR1、type 1 ryanodine receptor
[★]
- 関
- ryanodine receptor 2、RyR2、type 2 ryanodine receptor
[★]
- 関
- RyR1、skeletal muscle ryanodine receptor、type 1 ryanodine receptor
[★]
- 関
- ryanodine receptor 1、RyR1、skeletal muscle ryanodine receptor
[★]
- 関
- cardiac ryanodine receptor、ryanodine receptor 2、RyR2