円形細胞

WordNet

wind around; move along a circular course; "round the bend"
become round, plump, or shapely; "The young woman is fleshing out" (同)flesh out, fill out
make round; "round the edges" (同)round_out, round_off
the usual activities in your day; "the doctor made his rounds" (同)daily round
a charge of ammunition for a single shot (同)unit of ammunition, one shot
(often plural) a series of professional calls (usually in a set order); "the doctor goes on his rounds first thing every morning"; "the postmans rounds"; "we enjoyed our round of the local bars"
a serving to each of a group (usually alcoholic); "he ordered a second round" (同)round of drinks
a partsong in which voices follow each other; one voice starts and others join in one after another until all are singing different parts of the song at the same time; "they enjoyed singing rounds" (同)troll
a cut of beef between the rump and the lower leg
an outburst of applause; "there was a round of applause"
the course along which communications spread; "the story is going the rounds in Washington"
from beginning to end; throughout; "It rains all year round on Skye"; "frigid weather the year around" (同)around
having a circular shape (同)circular
pronounce with rounded lips (同)labialize, labialise
(mathematics) expressed to the nearest integer, ten, hundred, or thousand; "in round numbers"
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
(mathematics) a miscalculation that results from rounding off numbers to a convenient number of decimals; "the error in the calculation was attributable to rounding"; "taxes are rounded off to the nearest dollar but the rounding error is surprisingly small" (同)rounding error
curving and somewhat round in shape rather than jagged; "low rounded hills"; "rounded shoulders"

PrepTutorEJDIC

…『を[ぐるっと]回って』,を一周して / …『を曲がって』 / …『の周囲に』,を取り巻いて / …『のあちこちに』,の辺りに / …『ころ』 / (ぐるりと)回って,巡って / 周囲が(に) / あちこち[に],方々[に];行き渡って / 回り道して / (ある場所へ)回って / 『球状の』,丸い / (タイヤ・輪のように)円形の,丸い / (断面の丸い)円筒(円錐)形の / (肩・筆跡などが)丸みのある,丸々とした / 《名詞の前にのみ用いて》(数量が)完全の,ちょうどの / 『丸い物』;円,輪;球,円筒形 / (中心・軸をまわる)『回転』,(天体の)回転運動 / 《しばしば複数形で》(職務上などの)巡回,見回り / 《単数形で》(行い・でき事の一つの)連続;繰り返り;(…が)ひとしきり続くこと《+『of』+『名』》 / (ボクシングの一勝負の中の)『ラウンド』,回,(ゴルフデ全部のホールを回る)ラウンド,(カードゲームの)一回り / 輪唱 / (銃砲の)1回の射撃,一斉射撃 / (射撃用弾薬の)1回分 / (牛のもも肉の)丸切り,(パンの)丸切り《+『of』+『名』》 / 輪舞,円舞 / …‘を'『丸くする』,‘に'丸みをつける / …‘を'『回る』,曲がる / 〈端数をもつ数字〉‘を'端数を切り捨てて(概数で)表す《+『down』+『名』+『to』+『名』》 / …‘を'完成する,仕上げる / …‘を'くちびるを丸くして発音する / 『丸くなる』 / 回る,曲る / 完成する
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞

UpToDate Contents

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1. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
2. ALK陽性未分化大細胞型リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of anaplastic large cell lymphoma alk positive
3. 自家造血幹細胞移植の適格性判定 determining eligibility for autologous hematopoietic cell transplantation
4. 同種造血細胞移植の適応判定 determining eligibility for allogeneic hematopoietic cell transplantation
5. 肺の大細胞神経内分泌癌 large cell neuroendocrine carcinoma of the lung

English Journal

Potential Role of Voltage-Sensing Phosphatases in Regulation of Cell Structure Through the Production of PI(3,4)P2.

Yamaguchi S, Kurokawa T, Taira I, Aoki N, Sakata S, Okamura Y, Homma KJ.Author information Faculty of Pharmaceutical Sciences, Department of Life and Health Sciences, Teikyo University, Tokyo, Japan.AbstractVoltage-sensing phosphatase, VSP, consists of the transmembrane domain, operating as the voltage sensor, and the cytoplasmic domain with phosphoinositide-phosphatase activities. The voltage sensor tightly couples with the cytoplasmic phosphatase and membrane depolarization induces dephosphorylation of several species of phosphoinositides. VSP gene is conserved from urochordate to human. There are some diversities among VSP ortholog proteins; range of voltage of voltage sensor motions as well as substrate selectivity. In contrast with recent understandings of biophysical mechanisms of VSPs, little is known about its physiological roles. Here we report that chick ortholog of VSP (designated as Gg-VSP) induces morphological feature of cell process outgrowths with round cell body in DF-1 fibroblasts upon its forced expression. Expression of the voltage sensor mutant, Gg-VSPR153Q with shifted voltage dependence to a lower voltage led to more frequent changes of cell morphology than the wild-type protein. Coexpression of PTEN that dephosphorylates PI(3,4)P2 suppressed this effect by Gg-VSP, indicating that the increase of PI(3,4)P2 leads to changes of cell shape. In addition, visualization of PI(3,4)P2 with the fluorescent protein fused with the TAPP1-derived pleckstrin homology (PH) domain suggested that Gg-VSP influenced the distribution of PI(3,4)P2 . These findings raise a possibility that one of the VSP's functions could be to regulate cell morphology through voltage-sensitive tuning of phosphoinositide profile. J. Cell. Physiol. 229: 422-433, 2014. © 2013 Wiley Periodicals, Inc.
Journal of cellular physiology.J Cell Physiol.2014 Apr;229(4):422-33. doi: 10.1002/jcp.24463.
Voltage-sensing phosphatase, VSP, consists of the transmembrane domain, operating as the voltage sensor, and the cytoplasmic domain with phosphoinositide-phosphatase activities. The voltage sensor tightly couples with the cytoplasmic phosphatase and membrane depolarization induces dephosphorylation
PMID 24038012

Eyelid sebaceous carcinoma: clinicopathologic and multiparametric immunohistochemical analysis that includes adipophilin.

Jakobiec FA1, Mendoza PR2.Author information 1David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary; and Harvard Medical School, Boston, Massachusetts. Electronic address: Fred_Jakobiec@meei.harvard.edu.2David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary; and Harvard Medical School, Boston, Massachusetts.AbstractPURPOSE: To evaluate the fine cytopathologic features and immunohistochemistry of eyelid sebaceous carcinoma.
American journal of ophthalmology.Am J Ophthalmol.2014 Jan;157(1):186-208.e2. doi: 10.1016/j.ajo.2013.08.015. Epub 2013 Oct 7.
PURPOSE: To evaluate the fine cytopathologic features and immunohistochemistry of eyelid sebaceous carcinoma.DESIGN: Retrospective clinicopathologic study.METHODS: Clinical records and microscopic glass slides of 12 patients diagnosed with sebaceous carcinoma were reviewed. Paraffin-embedded tissue
PMID 24112633

Ewing's Sarcoma Cancer Stem Cell Targeted Therapy.

Todorova R.Author information IBPhBME-BAS, Acad G Bonchev str, Bl 21, 1113 Sofia, Bulgaria. todorova@bio21.bas.bg.AbstractEwing`s sarcoma (ES) family of tumors (ESFTs) are round cell tumors of bone and soft tissues, afflicting children and young adults. This review summarizes the present findings about ES cancer stem cell (CSC) targeted therapy: prognostic factors, chromosomal translocations, initiation, epigenetic mechanisms, candidate cell of ES origin (Mesenchymal stem cells (MSCs) and Neural crest stem cells (NCSCs)). The ES CSC model, histopathogenesis, histogenesis, pathogenesis, ES mediated Hematopoietic stem progenitor cells (HSPCs) senescence are also discussed. ESFTs therapy is reviewed concerning CSCs, radiotherapy, risk of subsequent neoplasms, stem cell (SC) support, promising therapeutic targets for ES CSCs (CSC markers, immune targeting, RNAi phenotyping screens, proposed new drugs), candidate EWS-FLI1 target genes and further directions (including human embryonic stem cells (hESCs)). Bone marrowderived human MSCs are permissive for EWS-FLI1 expression with transition to ESFT-like cellular phenotype. ESFTs are genetically related to NCSC, permissive for EWS-FLI1 expression and susceptible to oncogene-induced immortalization. Primitive neuroectodermal features and MSC origin of ESFTs provide a basis of immune targeting. The microRNAs profile of ES CSCs is shared by ESCs and CSCs from divergent tumor types. Successful reprogramming of differentiated human somatic cells into a pluripotent state allows creation of patient- and disease-specific SCs. The functional role of endogenous EWS at stem cell level on both senescence and tumorigenesis is a link between cancer and aging. The regulatory mechanisms of oncogenic activity of EWS fusions could provide new prognostic biomarkers, therapeutic opportunities and tumor-specific anticancer agents against ESFTs.
Current stem cell research & therapy.Curr Stem Cell Res Ther.2014 Jan;9(1):46-62.
Ewing`s sarcoma (ES) family of tumors (ESFTs) are round cell tumors of bone and soft tissues, afflicting children and young adults. This review summarizes the present findings about ES cancer stem cell (CSC) targeted therapy: prognostic factors, chromosomal translocations, initiation, epigenetic mec
PMID 24294922

Japanese Journal

Conformational Properties of Prion Strains Can Be Transmitted to Recombinant Prion Protein Fibrils in Real-Time Quaking-Induced Conversion

Sano Kazunori,Atarashi Ryuichiro,Ishibashi Daisuke,Nakagaki Takehiro,Satoh Katsuya,Nishida Noriyuki
Journal of Virology 88(20), 11791-11801, 2014-10
… Real-time quaking-induced conversion (RT-QUIC) is a cell-free system that uses Escherichia coli-derived recombinant PrP (rPrP) for the sensitive detection of PrPSc. … In the first round of the reaction, there were differences in the secondary structures, especially in bands attributed to β-sheets, as determined by infrared spectroscopy, and conformational stability between Chandler-seeded (1st-rPrP-fibCh) and 22L-seeded (1st-rPrP- fib22L) rPrP fibrils. …
NAID 120005512154