romurtide

English Journal

A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18) and IFN-β synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth.

Fujimura T1, Yamasaki K, Hidaka T, Ito Y, Aiba S.
Journal of dermatological science.J Dermatol Sci.2011 May;62(2):107-15. doi: 10.1016/j.jdermsci.2011.02.002. Epub 2011 Feb 22.
BACKGROUND: A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18), mimics the bacterial peptidoglycan moiety and acts as a powerful adjuvant that induces cell-mediated immunity.OBJECTIVE: To investigate the induction of antitumor immune response for malignant melanoma by IFN-β in combination
PMID 21411292

Sato T1, Shikama Y, Shimauchi H, Endo Y, Takada H.
Innate immunity.Innate Immun.2011 Feb;17(1):54-9. doi: 10.1177/1753425909351904. Epub 2010 Jan 18.
Intracellular nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, recognize the diaminopimelic acid (DAP)-containing peptide moiety and muramyldipeptide (MDP) moiety of bacterial peptidoglycan, respectively. Muramyldipeptide has been reported to exert analgesic activity to
PMID 20083500

Differential effects of GM-CSF and G-CSF on infiltration of dendritic cells during early left ventricular remodeling after myocardial infarction.

Naito K1, Anzai T, Sugano Y, Maekawa Y, Kohno T, Yoshikawa T, Matsuno K, Ogawa S.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2008 Oct 15;181(8):5691-701.
Several lines of evidence suggest that the immune activation after myocardial infarction (MI) induces secondary myocardial injury. Although dendritic cells (DC) are potent regulators of immunity, their role in MI is still undetermined. We investigated the effect of DC modulation by CSF on left ventr
PMID 18832728

東市郎
結核 73(2), 65-70, 1998-02-15
… We have synthesized several hundreds of MDP derivatives and selected, MDP-Lys (L18), romurtide, as the candidate of cytokine inducer for the clinical application. … Romurtide is applied in cancer patients for the recovery of the number and functions of monocytes, neutrophils and platelets. …
NAID 10008113328

Romurtide, a synthetic muramyl dipeptide derivative, promotes megakaryocytopoiesis through stimulation of cytokine production in nonhuman primates with myelosuppression.

Kenji Namba,Eiko Yamamura,Hironobu Nitanai,Tsuyoshi Otani,Ichiro Azuma.
Collected papers from the Institute of Immunological Science Hokkaido University 20, 183-191, 1997
NAID 110000001113