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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/17 14:49:24」(JST)

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Rolitetracycline is a tetracycline antibiotic. Tetracycline is N-Mannich base prodrug that is prepared from tetracycline by condensation with pyrrolidine and formaldehyde to produce rolitetracycline.

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English Journal

pH-dependent spectroscopy of tetracycline and its analogs.

Mojica ER1, Nguyen E, Rozov M, Bright FV.
Journal of fluorescence.J Fluoresc.2014 Jul;24(4):1183-98. doi: 10.1007/s10895-014-1399-7. Epub 2014 May 9.
Tetracyclines (TCs), broad spectrum antibiotics widely used in the prevention and treatment of infectious diseases, are amphoteric molecules containing several ionizable functional groups that exist predominantly as zwitterions at a given pH value. TCs are reported to undergo a wide variety of react
PMID 24806484

Production of a monoclonal antibody against oxytetracycline and its application for oxytetracycline residue detection in shrimp.

Wongtangprasert T1, Natakuathung W, Pimpitak U, Buakeaw A, Palaga T, Komolpis K, Khongchareonporn N.
Journal of Zhejiang University. Science. B.J Zhejiang Univ Sci B.2014 Feb;15(2):165-72. doi: 10.1631/jzus.B1300181.
A novel monoclonal antibody (MAb) against oxytetracycline (OTC) was generated and characterized. The MAb was used in the development of an enzyme-linked immunosorbant assay (ELISA)-based detection system. An OTC-bovine serum albumin (BSA) conjugate was prepared and used in the immunization of mice.
PMID 24510709

A novel approach to modeling the reaction kinetics of tetracycline antibiotics with aqueous ozone.

Hopkins ZR1, Blaney L.
The Science of the total environment.Sci Total Environ.2014 Jan 15;468-469:337-44. doi: 10.1016/j.scitotenv.2013.08.032. Epub 2013 Sep 14.
Tetracycline antibiotics represent one of the most successful classes of pharmaceuticals and are extensively used around the world for human and veterinary health. Ozone-based processes have emerged as a selective water treatment process for many pharmaceuticals. The primary objective of this study
PMID 24041601

Japanese Journal

経皮的腎嚢胞穿刺による Rolitetracycline 注入療法

長田恵弘
西日泌尿 50, 93-97, 1988
NAID 50002653010

超音波監視下経皮的穿刺による腎嚢胞の治療 : 腎嚢胞内Rolitetracycline注入療法について : 第50回東部総会

長田恵弘,中島登,宮北英司,西澤和亮,川嶋敏文
日本泌尿器科學會雜誌 77(10), 1696, 1986-10-20
NAID 110003057520

Related Pictures

★リンクテーブル★

リンク元	「テトラサイクリン系抗菌薬」「ロリテトラサイクリン」
拡張検索	「rolitetracycline nitrate」

「テトラサイクリン系抗菌薬」

Rolitetracycline
Clinical data
ATC code	J01AA09 (WHO)
Identifiers
	IUPAC name (2Z,4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-2-{hydroxy[(pyrrolidin-1-ylmethyl)amino]methylene}-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione;
Synonyms	(2Z,4S,4aS,5aS,6S,12aS)-4-dimethylamino-6,10,11,12a-tetrahydroxy-2-[hydroxy-(pyrrolidin-1-ylmethylamino)methylidene]-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
CAS Number	751-97-3
PubChem (CID)	5282179
DrugBank	DB01301
ChemSpider	10469507
UNII	GH9IW85221
KEGG	D02282
ChEMBL	CHEMBL1214184
ECHA InfoCard	100.010.938
Chemical and physical data
Formula	C27H33N3O8
Molar mass	527.566 g/mol
3D model (Jmol)	Interactive image
	SMILES O=C(NCN1CCCC1)\C2=C(/O)[C@@H](N(C)C)[C@@H]3CC5C(=C(\O)[C@]3(O)C2=O)\C(=O)c4c(O)cccc4[C@@]5(C)O ;
	InChI InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31,33-34,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14?,15-,20-,26+,27-/m0/s1 ; Key:HMEYVGGHISAPJR-VQCPGFMQSA-N ;
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