WordNet

of the transmission gear causing backward movement in a motor vehicle; "in reverse gear"
a relation of direct opposition; "we thought Sue was older than Bill but just the reverse was true" (同)contrary, opposite
the gears by which the motion of a machine can be reversed (同)reverse gear
the side of a coin or medal that does not bear the principal design (同)verso
(American football) a running play in which a back running in one direction hands the ball to a back running in the opposite direction
an unfortunate happening that hinders or impedes; something that is thwarting or frustrating (同)reversal, setback, blow, black_eye
the science or study of drugs: their preparation and properties and uses and effects (同)pharmacological medicine, materia_medica
a lapel on a womans garment; turned back to show the reverse side (同)revere
turned inside out and resewn; "the reversed collar looked as good as new"

PrepTutorEJDIC

(位置・方向・順序などにおいて)『逆の』;裏側の』 / 逆に動かす(動く),バックの / 〈U〉《the reverse》(…の)『反対』,『逆』《+『of』+『名』(『wh』‐節)》》 / 〈U〉《the reverse》(貨幣・メダルなどの)『裏側』,(一般に)(…の)裏面《+『of』+『名』》 / 〈C〉(運命などの)逆転,不運 / 〈U〉後退[装置],逆転[装置] / …‘を'『逆にする』,反対にする;…‘を'裏返す / 〈機械など〉‘を'逆転させる,逆方向に動かす / 〈判決など〉‘を'取り消す,破棄する / (ダンスで)逆に回る / 〈機械などが〉逆方向に動く
薬学,薬物学,薬理学
（フランス語）(えりの)裏出し,折り返し
逆にした,反対の,裏返のし;取り消された

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/27 22:31:49」(JST)

wiki en

In the field of drug discovery, reverse pharmacology ^[1]^[2]^[3] also known as target base drug discovery (TDD),^[4] a hypothesis is first made that modulation of the activity of a specific protein target will have beneficial therapeutic effects. Screening of chemical libraries of small molecules is then used to identify compounds that bind with high affinity to the target. The hits from these screens are then used as starting points for drug discovery. This method became popular after the sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins. This method is the most widely used in drug discovery today.^[5]

References

^ Takenaka T (September 2001). "Classical vs reverse pharmacology in drug discovery". BJU Int. 88 Suppl 2: 7–10; discussion 49–50. doi:10.1111/j.1464-410X.2001.00112.x. PMID 11589663.
^ Lazo JS (April 2008). "Rear-view mirrors and crystal balls: a brief reflection on drug discovery". Mol. Interv. 8 (2): 60–3. doi:10.1124/mi.8.2.1. PMID 18403648.
^ Bachmann KA, Hacker MP, Messer W (2009). Pharmacology principles and practice. Amsterdam: Elsevier/Academic Press. p. 576. ISBN 0-12-369521-X.
^ Lee JA, Uhlik MT, Moxham CM, Tomandl D, Sall DJ (May 2012). "Modern phenotypic drug discovery is a viable, neoclassic pharma strategy". J. Med. Chem. 55 (10): 4527–38. doi:10.1021/jm201649s. PMID 22409666.
^ Swinney DC, Anthony J (July 2011). "How were new medicines discovered?". Nat Rev Drug Discov 10 (7): 507–19. doi:10.1038/nrd3480. PMID 21701501.

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Integrin-targeted nanoparticles are promising for the delivery of small interfering RNA (siRNA) to tumor cells or tumor endothelium in cancer therapy aiming at silencing genes essential for tumor growth. However, during the process of optimizing and realizing their full potential, it is pertinent to
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Japanese Journal

Vinpocetine improves scopolamine induced learning and memory dysfunction in C57 BL/6J mice

Biological and Pharmaceutical Bulletin advpub(0), 2016
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Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs

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「reverse」

　　[★]

v.

逆転させる、逆行する、逆戻りさせる、リバースする

adj.

逆の、逆性の

関: adversely、backward、converse、conversely、inverse、inversely、opposite、oppositely、retro、reversal

[pmid11589663-1] Takenaka T (September 2001). "Classical vs reverse pharmacology in drug discovery". BJU Int. 88 Suppl 2: 7–10; discussion 49–50. doi:10.1111/j.1464-410X.2001.00112.x. PMID 11589663.

[pmid18403648-2] Lazo JS (April 2008). "Rear-view mirrors and crystal balls: a brief reflection on drug discovery". Mol. Interv. 8 (2): 60–3. doi:10.1124/mi.8.2.1. PMID 18403648.

[isbn0-12-369521-X-3] Bachmann KA, Hacker MP, Messer W (2009). Pharmacology principles and practice. Amsterdam: Elsevier/Academic Press. p. 576. ISBN 0-12-369521-X.

[pmid22409666-4] Lee JA, Uhlik MT, Moxham CM, Tomandl D, Sall DJ (May 2012). "Modern phenotypic drug discovery is a viable, neoclassic pharma strategy". J. Med. Chem. 55 (10): 4527–38. doi:10.1021/jm201649s. PMID 22409666.

[Swinney_2011-5] Swinney DC, Anthony J (July 2011). "How were new medicines discovered?". Nat Rev Drug Discov 10 (7): 507–19. doi:10.1038/nrd3480. PMID 21701501.

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案内

案内

reverse pharmacology