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a unit of magnetic field strength equal to one-hundred-thousandth of an oersted
the 3rd letter of the Greek alphabet
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the 24th letter of the Roman alphabet (同)x, ex
a herd of whales

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ガンマ(ギリシア語アルファベットの第3字Γ,γ;英語のG,gに相当)
=sense organ / 受信装置
Christ / Christian
(特に女性の)魅力的な脚,すんなりした脚
x-axis

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/26 17:44:55」(JST)

wiki en

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.^[1]^[2]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

Interactions

Retinoid X receptor gamma has been shown to interact with ITGB3BP.^[3]

References

^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312.
^ ^a ^b "Entrez Gene: RXRG retinoid X receptor, gamma".
^ Li, D; Wang F, Samuels H H (Dec 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMC 100002. PMID 11713274. Cite uses deprecated parameters (help)

UpToDate Contents

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1. 急性前骨髄球性白血病の分子生物学 molecular biology of acute promyelocytic leukemia
2. セザリー症候群の治療 treatment of sezary syndrome
3. 甲状腺ホルモンの作用 thyroid hormone action
4. 分化（レチノイン酸）症候群 differentiation retinoic acid syndrome
5. 中枢性甲状腺機能低下症 central hypothyroidism

English Journal

Epigallocatechin-3-gallate Increases RXRγ-mediated Pro-apoptotic and Anti-invasive Effects in Gastrointestinal Cancer Cell Lines.

Papi A1, Govoni M, Ciavarella C, Spisni E, Orlandi M, Farabegoli F.
Current cancer drug targets.Curr Cancer Drug Targets.2016;16(4):373-85.
Molecules with synergistic effects often enhance the benefits of cancer therapy. We observed that the major catechin of green tea, (-)-Epigallocatechin-3-gallate (EGCG), induced retinoid X receptor-γ (RXRγ) expression in the SK-Ch-A1 cholangiocarcinoma cell line and in two colon carcinoma cell lin
PMID 26278714

Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.

de la Fuente AG1, Errea O1, van Wijngaarden P2, Gonzalez GA1, Kerninon C3, Jarjour AA4, Lewis HJ5, Jones CA5, Nait-Oumesmar B3, Zhao C1, Huang JK6, ffrench-Constant C4, Franklin RJ7.
The Journal of cell biology.J Cell Biol.2015 Dec 7;211(5):975-85. doi: 10.1083/jcb.201505119.
The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear
PMID 26644513

Regulation of Retinoic Acid Receptor Beta by Interleukin-15 in the Lung during Cigarette Smoking and Influenza Virus Infection.

Wang J1,2, Liu W1, Marion C1, Singh R1, Andrews N1, Lee CG3, Elias JA3, Dela Cruz CS1.
American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2015 Dec;53(6):822-33. doi: 10.1165/rcmb.2014-0448OC.
Virus-induced exacerbations often lead to further impairment of lung function in chronic obstructive pulmonary disease. IL-15 is critical in antiviral immune responses. Retinoic acid (RA) signaling plays an important role in tissue maintenance and repair, particularly in the lung. We studied RA sign
PMID 25923039

Japanese Journal

The role of the IL-23/IL-17 axis in the pathogenesis of Graves' disease

Endocrine journal 60(5), 591-597, 2013-05-01
NAID 10031184526

毛包向性菌状息肉症 (folliculotropic mycosis fungoides) の1例

Skin cancer : official organ of the Japanese Society for Skin Cancer = 皮膚悪性腫瘍研究会機関誌 25(2), 145-149, 2010-09-15
NAID 10027731597

Possible Involvement of p38 MAP Kinase in Retinoid-stimulated Expression of Indian Hedgehog in Prehypertrophic Chondrocytes

Oral science international : official journal of the Japanese Stomatological Society 5(1), 1-14, 2008-05-01
NAID 10024185761

「レチノイドX受容体γ」

Retinoid X receptor, gamma
	; Crystallographic structure of the DNA-binding domain of the Retinoid X receptor, gamma. PDB rendering based on 1by4.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2GL8
Identifiers
Symbols	RXRG ; NR2B3; RXRC
External IDs	OMIM: 180247 MGI: 98216 HomoloGene: 21373 IUPHAR: NR2B3 ChEMBL: 2004 GeneCards: RXRG Gene
Gene ontology
Molecular function	• steroid hormone receptor activity; • 9-cis retinoic acid receptor activity; • zinc ion binding; • sequence-specific DNA binding;
Cellular component	• nucleoplasm;
Biological process	• transcription initiation from RNA polymerase II promoter; • peripheral nervous system development; • heart development; • skeletal muscle tissue development; • gene expression; • neuron differentiation; • regulation of myelination; • response to retinoic acid; • positive regulation of transcription from RNA polymerase II promoter;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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