WordNet

to remain unmolested, undisturbed, or uninterrupted -- used only in infinitive form; "let her be"
work in a specific place, with a specific subject, or in a specific function; "He is a herpetologist"; "She is our resident philosopher" (同)follow
have life, be alive; "Our great leader is no more"; "My grandfather lived until the end of war" (同)live
be identical to; be someone or something; "The president of the company is John Smith"; "This is my house"
happen, occur, take place; "I lost my wallet; this was during the visit to my parents house"; "There were two hundred people at his funeral"; "There was a lot of noise in the kitchen"
have the quality of being; (copula, used with an adjective or a predicate noun); "John is rich"; "This is not a good answer"
occupy a certain position or area; be somewhere; "Where is my umbrella?" "The toolshed is in the back"; "What is behind this behavior?"
spend or use time; "I may be an hour"
stake on the outcome of an issue; "I bet $100 on that new horse"; "She played all her money on the dark horse" (同)wager, play
the act of gambling; "he did it on a bet" (同)wager
maintain with or as if with a bet; "I bet she will be there!" (同)wager
second in order of importance; "the candidate, considered a beta male, was perceived to be unable to lead his party to victory"
the 2nd letter of the Greek alphabet
preliminary or testing stage of a software or hardware product; "a beta version"; "beta software"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the 24th letter of the Roman alphabet (同)x, ex

PrepTutorEJDIC

《連結語として補語を伴なって…『である』,…だ,…です / 《位置・場所を表す語句を伴って》(…に)『ある』,いる(occupy a place or situation) / 〈物事が〉『存在する』,ある(exist);〈生物が〉生存する,生きている(live) / 行われる,起こる,発生する(take place, occur) / 存続する,そのままでいる(remain as before) / 《『be to』 do》 / …する予定である,…することになっている / …すべきだ / 《受動態の不定詞を伴って》…できる / 《命令》…するのだ / 《条件節に》…する意図がある / 《『if…were to』 do》…するとしたなら / 《『be』 do『ing』》《進行形》 / 《進行中の動作》…している,しつつある / 《近い未来》…しようとしている,するつもり / 《動作の反復》(いつも)…している / 《『be』+『他動詞の過去分詞』》《受動態》…される,されている / 《『be』+『自動詞の過去分詞』》《完了形》…した[状態にある]
『かけ』・(…との)かけ《+『with』+『名』》 / かけた物(金) / かけの対象 / 〈金・物〉'を'『かける』 / (かけ事・ゲームなどで)〈人〉‘と'『かけをする』《+『名』〈人〉+『on』+『名』》 / (…に)『かける』《+『on』(『against』)+『名』(one's do『ing』)》
ベータ(ギリシア語アルファベットの第2文字;B,β;英語のB,b に遭当)
=sense organ / 受信装置
Christ / Christian

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/05 09:45:24」(JST)

wiki en

Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene.^[1]^[2]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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Vitamin D Synthesis Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "VitaminDSynthesis_WP1531".

References

^ Fitzgibbon J, Gillett GT, Woodward KJ, Boyle JM, Wolfe J, Povey S (July 1993). "Mapping of RXRB to human chromosome 6p21.3". Ann. Hum. Genet. 57 (Pt 3): 203–9. doi:10.1111/j.1469-1809.1993.tb01596.x. PMID 8257090.
^ ^a ^b "Entrez Gene: RXRB retinoid X receptor, beta".

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 甲状腺ホルモンとの薬物相互作用 drug interactions with thyroid hormones
2. 甲状腺ホルモンの作用 thyroid hormone action
3. 中枢性甲状腺機能低下症 central hypothyroidism
4. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
5. 甲状腺ホルモンに対する感受性の傷害 impaired sensitivity to thyroid hormone

English Journal

Expression of retinoid X receptor beta is induced in astrocytes during corpus callosum demyelination.

König R, Stillfried M, Aperdannier P, Clarner T, Beyer C, Kipp M, Mey J.SourceInstitut für Biologie II, RWTH Aachen, Germany.
Journal of chemical neuroanatomy.J Chem Neuroanat.2012 Mar;43(2):120-32. doi: 10.1016/j.jchemneu.2012.01.002. Epub 2012 Jan 28.
The experimental activation of retinoid receptors reduces pathological symptoms in animal models of multiple sclerosis. In order to assess the involvement of endogenous retinoid signaling during the process of demyelination we investigated retinoic acid synthesizing enzymes and nuclear receptors usi
PMID 22306550

Computational studies of LXR molecular interactions reveal an allosteric communication pathway.

Burendahl S, Nilsson L.SourceDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Proteins.Proteins.2012 Jan;80(1):294-306. doi: 10.1002/prot.23209. Epub 2011 Nov 9.
The liver X receptor, LXRα, is an important regulator of genes involved in metabolism and inflammation. The mechanism of communication between the cofactor peptide and the ligand in the ligand-binding pocket is a crucial and often discussed issue for the nuclear receptors (NRs), but such allosteric
PMID 22072626

Japanese Journal

Tamibarotene: A Candidate Retinoid Drug for Alzheimer's Disease

Biological and Pharmaceutical Bulletin 35(8), 1206-1212, 2012
NAID 130001872152

Honokiol increases ABCA1 expression level by activating retinoid X receptor beta

Biol Pharm Bull 33, 1105-1111, 2010
NAID 50007615735

Honokiol Increases ABCA1 Expression Level by Activating Retinoid X Receptor Beta

Biological and Pharmaceutical Bulletin 33(7), 1105-1111, 2010
NAID 130000300271

「レチノイドX受容体β」

Retinoid X receptor, beta
	; PDB rendering based on 1by4.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1H9U, 1UHL
Identifiers
Symbols	RXRB ; DAUDI6; H-2RIIBP; NR2B2; RCoR-1
External IDs	OMIM: 180246 MGI: 98215 HomoloGene: 7923 IUPHAR: NR2B2 ChEMBL: 1870 GeneCards: RXRB Gene
Gene ontology
Molecular function	• RNA polymerase II regulatory region sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; • sequence-specific DNA binding transcription factor activity; • steroid hormone receptor activity; • transcription coactivator activity; • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; • 9-cis retinoic acid receptor activity; • protein binding; • zinc ion binding;
Cellular component	• nucleus; • nucleoplasm;
Biological process	• in utero embryonic development; • maternal placenta development; • transcription initiation from RNA polymerase II promoter; • gene expression; • steroid hormone mediated signaling pathway; • positive regulation of transcription from RNA polymerase II promoter; • retinoic acid receptor signaling pathway; • ventricular cardiac muscle cell differentiation; • cardiac muscle cell proliferation; • cellular response to retinoic acid;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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