WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/29 21:52:06」(JST)

wiki en

Retinoic acid syndrome (RAS) is a potentially life threatening complication observed in patients with acute promyelocytic leukemia (APML) and first thought to be specifically associated with all-trans retinoic acid (ATRA) (also known as tretinoin) treatment.^[1] Subsequently it was recognized that so-called RAS appeared in APML patients who had been treated with another highly efficacious drug, arsenic trioxide, and yet did not appear in patients treated with tretinoin for other disorders. These facts and others support the notion that RAS depends on the presence of the malignant promyelocytes. This has led to the growing deprecation of the term 'retinoic acid syndrome' and to an increasing use of the term differentiation syndrome to signify this APML treatment complication.^[2]

Presentation[edit]

The syndrome is characterized by dyspnea, fever, weight gain, hypotension, and pulmonary infiltrates. This is effectively treated by giving dexamethasone and holding ATRA (or arsenic trioxide) in severe cases. An elevated white count is sometimes associated with this syndrome, but is not a prerequisite.

Once RAS has resolved, pro-differentiation chemotherapy can be resumed.

Etiology[edit]

The etiology of RAS is not clear cut. Several causes have been speculated including a capillary leak syndrome from cytokine release from the differentiating myeloid cells. Alternatively, ATRA may cause the maturing myeloid cells to acquire the ability to infiltrate organs such as the lung.

Mediation by cathepsin G has been suggested.^[3]

References[edit]

^ Breccia M, Latagliata R, Carmosino I, et al. (December 2008). "Clinical and biological features of acute promyelocytic leukemia patients developing retinoic acid syndrome during induction treatment with all-trans retinoic acid and idarubicin". Haematologica 93 (12): 1918–20. doi:10.3324/haematol.13510. PMID 18945746.
^ Weinberger, Steven. "Differentiation (retinoic acid) syndrome". Retrieved 10 March 2011.
^ Tallman MS (February 2002). "Retinoic acid syndrome: a problem of the past?". Leukemia 16 (2): 160–1. doi:10.1038/sj.leu.2402344. PMID 11840279.

This article about a disease, disorder, or medical condition is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 分化（レチノイン酸）症候群 differentiation retinoic acid syndrome
2. 分化型甲状腺癌：マネージメントの概要 differentiated thyroid cancer overview of management
3. ビタミンAの概要 overview of vitamin a
4. 成人における急性前骨髄球性白血病の初期治療 initial treatment of acute promyelocytic leukemia in adults
5. 分化型甲状腺癌：放射性ヨード治療 differentiated thyroid cancer radioiodine treatment

English Journal

Circulating retinoic acid levels and the development of metabolic syndrome.

Liu Y1, Chen H1, Mu D1, Fan J1, Song J1, Zhong Y1, Li D1, Xia M1.
The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2016 Feb 10:jc20154038. [Epub ahead of print]
CONTEXT AND OBJECTIVE: In this prospective study, we evaluated the association of retinoic acid (RA) with the metabolic syndrome (MetS) in Chinese population.DESIGN AND PARTICIPANTS: 1042 nondiabetic adults from the population-based Nutrition and Health of Aging Population were prospectively followe
PMID 26863424

Acute myeloid leukemia in children: Current status and future directions.

Taga T1, Tomizawa D2, Takahashi H3, Adachi S4.
Pediatrics international : official journal of the Japan Pediatric Society.Pediatr Int.2016 Feb;58(2):71-80. doi: 10.1111/ped.12865.
Acute myeloid leukemia (AML) accounts for 25% of pediatric leukemia and affects approximately 180 patients annually in Japan. The treatment outcome for pediatric AML has improved through advances in chemotherapy, hematopoietic stem cell transplantation (HSCT), supportive care, and optimal risk strat
PMID 26645706

Japanese Journal

APL分化症候群の治療と予防

前田智也,麻生範雄
血液内科 70(2), 260-267, 2015-02
NAID 40020385349

Hemophagocytic Syndrome and Inflammatory Myopathy with Abundant Macrophages in a Patient with Adult-onset Still's Disease

Umeda Masataka,Origuchi Tomoki,Fujikawa Keita,Koga Tomohiro,Mizokami Akinari,Nakashima Yoshikazu,Suzuki Takahisa,Okada Akitomo,Kawashiri Shin-ya,Ichinose Kunihiro,Tamai Mami,Yamasaki Satoshi,Nakamura Hideki,Kawakami Atsushi,Eguchi Katsumi
Internal Medicine 53(20), 2385-2389, 2014-10-15
… The bone marrow aspiration and muscle biopsy revealed hemophagocytic syndrome (HPS) and inflammatory myopathy with abundant macrophages (IMAM). … Immunostained specimens were positive for expression of retinoic acid-inducible gene-I (RIG-I), which recognizes viral RNA in infiltrated mononuclear cells as well as muscle tissues. …
NAID 120005517841