retinoblastoma tumor suppressor

• 網膜芽細胞腫抑制因子

WordNet

1. to put down by force or authority; "suppress a nascent uprising"; "stamp down on littering"; "conquer ones desires" (同)stamp down, inhibit, subdue, conquer, curb
2. reduce the incidence or severity of or stop; "suppress a yawn"; "this drug can suppress the hemorrhage"
3. put out of ones consciousness (同)repress
4. an electrical device for suppressing unwanted currents (同)suppresser
5. someone who suppresses; "dictators are suppressors of free speech" (同)suppresser
6. a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene) (同)suppresser, suppressor_gene, suppresser gene
7. malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells
8. an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm

PrepTutorEJDIC

1. 〈反乱など〉‘を'『鎮圧する』…,‘の'活動を押える / 〈感情・欲望など〉‘を'『抑制する』,抑える / …‘の'発表を禁止する,伏せる
2. 抑圧する人,鎮圧者 / (ラジオ・テレビの)妨害電波(混信)防止装置

UpToDate Contents

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• 1. 網膜芽細胞腫：臨床症状、評価、診断 retinoblastoma clinical presentation evaluation and diagnosis
• 2. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
• 3. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
• 4. 網膜芽細胞腫：治療と転帰 retinoblastoma treatment and outcome
• 5. 白色瞳孔を有する小児に対するアプローチ approach to the child with leukocoria

English Journal

• Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family.

• Liban TJ1, Thwaites MJ2, Dick FA2, Rubin SM3.
• Journal of molecular biology.J Mol Biol.2016 Oct 9;428(20):3960-3971. doi: 10.1016/j.jmb.2016.08.017. Epub 2016 Aug 25.
• The human pocket proteins retinoblastoma (Rb), p107, and p130 are critical negative regulators of the cell cycle and contribute to tumor suppression. While strong structural conservation within the pocket protein family provides for some functional redundancy, important differences have been observe
• PMID 27567532

• RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.

• Jones RA, Robinson TJ, Liu JC, Shrestha M, Voisin V, Ju Y, Chung PE, Pellecchia G, Fell VL, Bae S, Muthuswamy L, Datti A, Egan SE, Jiang Z, Leone G, Bader GD, Schimmer A, Zacksenhaus E.
• The Journal of clinical investigation.J Clin Invest.2016 Oct 3;126(10):3739-3757. doi: 10.1172/JCI81568. Epub 2016 Aug 29.
• Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which no specific treatment is currently available. Although the retinoblastoma tumor-suppressor gene (RB1) is frequently lost together with TP53 in TNBC, it is not directly targetable. There is thus great interest
• PMID 27571409

• miR-124 inhibits proliferation and invasion of human retinoblastoma cells by targeting STAT3.

• Liu S1, Hu C2, Wang Y3, Shi G2, Li Y2, Wu H1.
• Oncology reports.Oncol Rep.2016 Oct;36(4):2398-404. doi: 10.3892/or.2016.4999. Epub 2016 Aug 3.
• A growing body of evidence suggests that microRNA-124 (miR-124) functions as tumor-suppressor, and involves in tumor initiation, development and metastasis in major classes of human cancers; however, the biological role and underlying molecular mechanism of miR-124 in retinoblastoma (RB) remain unkn
• PMID 27498908

Japanese Journal

• Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation

• Cancer Science 108(2017), 1726-1731, 2017-09
• NAID 120006370944

• MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6

• Oncotarget 8(8), 13872-13885, 2017-01-01
• NAID 120006226780

• ATMを介してRBタンパク質はDNMT1タンパク質の安定性とDNAメチル化を制御する

• Molecular biology of the cell 33(16), 3113-3124, 2013-08-01
• NAID 120005312327

Related Links

• Retinoblastoma tumor suppressor protein in pancreatic ...

1. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8. doi: 10.1073/pnas.1303386110. Epub 2013 Aug 14. Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate. Cai EP(1), Wu ...

• The retinoblastoma tumor suppressor and stem cell biology

Basic functions of the RB pathway The human retinoblastoma gene RB1 was initially cloned from children with a rare form of eye cancer of the same name. Since this seminal discovery, RB has been found to be ...

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★リンクテーブル★

リンク元	「網膜芽細胞腫抑制因子」
関連記事	「suppress」「suppressor」「tumor suppressor」「tumor」

「網膜芽細胞腫抑制因子」

　　[★]

英

retinoblastoma tumor suppressor

「suppress」

　　[★]

• v.

• 抑制する、抑える、抑止する

関

abrogate、abrogation、arrest、curb、depress、depression、inhibit、inhibition、restrain、restraint、subdue、suppression

　 　 　 　

「suppressor」

　　[★]

• 抑制因子、抑圧因子、サプレッサー

関

inhibitory factor、repressor

　 　 　 　

「tumor suppressor」

　　[★]

• 腫瘍抑制因子、腫瘍抑制物質、発癌抑制物質、発がん抑制物質

「tumor」

　　[★]

• n.

• 腫瘍、腫瘤、腫脹