網膜芽細胞腫様タンパク質p130
WordNet
- want to have; "Id like a beer now!"
- a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
- a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
- equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
- resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
- be fond of; "I like my nephews"
- feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
- find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
- malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells
- found pleasant or attractive; often used as a combining form; "a well-liked teacher"
PrepTutorEJDIC
- …‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
- (外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
- 蛋白(たんばく)質
- (…の)『好み』,趣味《+『for』(『to』)+『名』》
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/29 09:22:59」(JST)
[Wiki en表示]
| Retinoblastoma-like 2 (p130) |
| Identifiers |
| Symbols |
RBL2 ; P130; Rb2 |
| External IDs |
OMIM: 180203 MGI: 105085 HomoloGene: 4098 GeneCards: RBL2 Gene |
| Gene ontology |
| Molecular function |
• DNA binding
• protein binding
|
| Cellular component |
• nucleus
• nucleoplasm
• transcription factor complex
• nucleolus
• cytoplasm
|
| Biological process |
• G1 phase of mitotic cell cycle
• mitotic cell cycle
• transcription, DNA-dependent
• regulation of transcription, DNA-dependent
• chromatin modification
• regulation of lipid kinase activity
• regulation of cell cycle
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
5934 |
19651 |
|
| Ensembl |
ENSG00000103479 |
ENSMUSG00000031666 |
|
| UniProt |
Q08999 |
Q64700 |
|
| RefSeq (mRNA) |
NM_005611 |
NM_011250 |
|
| RefSeq (protein) |
NP_005602 |
NP_035380 |
|
| Location (UCSC) |
Chr 16:
53.47 – 53.53 Mb |
Chr 8:
91.07 – 91.12 Mb |
|
| PubMed search |
[1] |
[2] |
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Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.[1][2]
Contents
- 1 Interactions
- 2 See also
- 3 Further reading
- 4 References
- 5 External links
Interactions
Retinoblastoma-like protein 2 has been shown to interact with HDAC1,[3][4] C-Raf,[5] RBBP8,[6][7] Cyclin E1,[8][9] Prohibitin,[10] Cyclin-dependent kinase 2,[8][11] BRF1[12] and BRCA1.[13]
See also
Further reading
- Soprano KJ, Purev E, Vuocolo S, Soprano DR (2006). "Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid.". Oncogene 25 (38): 5315–25. doi:10.1038/sj.onc.1209679. PMID 16936753.
- De Falco G, Giordano A (2006). "pRb2/p130: a new candidate for retinoblastoma tumor formation.". Oncogene 25 (38): 5333–40. doi:10.1038/sj.onc.1209614. PMID 16936755.
- Hijmans EM, Voorhoeve PM, Beijersbergen RL, et al. (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo.". Mol. Cell. Biol. 15 (6): 3082–9. PMC 230539. PMID 7760804.
- Sardet C, Vidal M, Cobrinik D, et al. (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
- Yeung RS, Bell DW, Testa JR, et al. (1993). "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19.". Oncogene 8 (12): 3465–8. PMID 8247552.
- Li Y, Graham C, Lacy S, et al. (1994). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.". Genes Dev. 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
- Hannon GJ, Demetrick D, Beach D (1994). "Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.". Genes Dev. 7 (12A): 2378–91. doi:10.1101/gad.7.12a.2378. PMID 8253384.
- Lavender P, Vandel L, Bannister AJ, Kouzarides T (1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A.". Oncogene 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. PMID 9178770.
- Lacy S, Whyte P (1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes.". Oncogene 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. PMID 9188854.
- Shao Z, Siegert JL, Ruppert S, Robbins PD (1997). "Rb interacts with TAF(II)250/TFIID through multiple domains.". Oncogene 15 (4): 385–92. doi:10.1038/sj.onc.1201204. PMID 9242374.
- Sterner JM, Dew-Knight S, Musahl C, et al. (1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7.". Mol. Cell. Biol. 18 (5): 2748–57. PMC 110654. PMID 9566894.
- Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.". Nat. Genet. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699.
- Veal E, Eisenstein M, Tseng ZH, Gill G (1998). "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F.". Mol. Cell. Biol. 18 (9): 5032–41. PMC 109088. PMID 9710587.
- Fusco C, Reymond A, Zervos AS (1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein.". Genomics 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.
- Ferreira R, Magnaghi-Jaulin L, Robin P, et al. (1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. PMC 27922. PMID 9724731.
- Paramio JM, Laín S, Segrelles C, et al. (1998). "Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation.". Oncogene 17 (8): 949–57. doi:10.1038/sj.onc.1202031. PMID 9747874.
- Wang S, Ghosh RN, Chellappan SP (1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation.". Mol. Cell. Biol. 18 (12): 7487–98. PMC 109329. PMID 9819434.
- Yang R, Müller C, Huynh V, et al. (1999). "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.". Mol. Cell. Biol. 19 (3): 2400–7. PMC 84032. PMID 10022926.
References
- ^ Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (September 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene 8 (9): 2561–6. PMID 8361765.
- ^ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (July 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proc Natl Acad Sci U S A 93 (10): 4629–32. doi:10.1073/pnas.93.10.4629. PMC 39329. PMID 8643454.
- ^ Ferreira, R; Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (September 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. ISSN 0027-8424. PMC 27922. PMID 9724731.
- ^ Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G (August 2000). "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Res. (UNITED STATES) 60 (16): 4531–7. ISSN 0008-5472. PMID 10969803.
- ^ Wang, S; Ghosh R N, Chellappan S P (Dec 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487–98. ISSN 0270-7306. PMC 109329. PMID 9819434.
- ^ Meloni, A R; Smith E J, Nevins J R (August 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574–9. doi:10.1073/pnas.96.17.9574. ISSN 0027-8424. PMC 22250. PMID 10449734.
- ^ Fusco, C; Reymond A, Zervos A S (August 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics (UNITED STATES) 51 (3): 351–8. doi:10.1006/geno.1998.5368. ISSN 0888-7543. PMID 9721205.
- ^ a b Shanahan, F; Seghezzi W, Parry D, Mahony D, Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460–9. ISSN 0270-7306. PMC 116074. PMID 9891079.
- ^ Li, Y; Graham C, Lacy S, Duncan A M, Whyte P (Dec 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes Dev. (UNITED STATES) 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. ISSN 0890-9369. PMID 8253383.
- ^ Wang, S; Nath N, Adlam M, Chellappan S (June 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene (ENGLAND) 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. ISSN 0950-9232. PMID 10376528.
- ^ Lacy, S; Whyte P (May 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene (ENGLAND) 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. ISSN 0950-9232. PMID 9188854.
- ^ Sutcliffe, J E; Cairns C A, McLees A, Allison S J, Tosh K, White R J (June 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255–61. ISSN 0270-7306. PMC 104385. PMID 10330166.
- ^ Fan, S; Yuan R, Ma Y X, Xiong J, Meng Q, Erdos M, Zhao J N, Goldberg I D, Pestell R G, Rosen E M (August 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene (England) 20 (35): 4827–41. doi:10.1038/sj.onc.1204666. ISSN 0950-9232. PMID 11521194.
External links
- RBL2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Transcription factors and intracellular receptors
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(1) Basic domains
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| (1.1) Basic leucine zipper (bZIP) |
- Activating transcription factor
- AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
- BACH
- BATF
- BLZF1
- C/EBP
- CREB
- CREM
- DBP
- DDIT3
- GABPA
- HLF
- MAF
- NFE
- NFIL3
- NRL
- NRF
- XBP1
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| (1.2) Basic helix-loop-helix (bHLH) |
- ATOH1
- AhR
- AHRR
- ARNT
- ASCL1
- BHLH
- ARNTL
- CLOCK
- EPAS1
- FIGLA
- HAND
- HES
- HEY
- HES1
- HIF
- ID
- LYL1
- MESP2
- MXD4
- MYCL1
- MYCN
- Myogenic regulatory factors
- Neurogenins
- NeuroD
- NPAS
- OLIG
- Pho4
- Scleraxis
- SIM
- TAL
- Twist
- USF1
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| (1.3) bHLH-ZIP |
- AP-4
- MAX
- MITF
- MNT
- MLX
- MXI1
- Myc
- SREBP
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| (1.4) NF-1 |
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| (1.5) RF-X |
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| (1.6) Basic helix-span-helix (bHSH) |
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(2) Zinc finger DNA-binding domains
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| (2.1) Nuclear receptor (Cys4) |
| subfamily 1 |
- Thyroid hormone
- CAR
- FXR
- LXR
- PPAR
- PXR
- RAR
- ROR
- Rev-ErbA
- VDR
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|
| subfamily 2 |
- COUP-TF
- Ear-2
- HNF4
- PNR
- RXR
- Testicular receptor
- TLX
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| subfamily 3 |
- Steroid hormone
- Androgen
- Estrogen
- Glucocorticoid
- Mineralocorticoid
- Progesterone
- Estrogen related
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| subfamily 4 |
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| subfamily 5 |
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| subfamily 6 |
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| subfamily 0 |
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| (2.2) Other Cys4 |
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| (2.3) Cys2His2 |
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| (2.4) Cys6 |
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| (2.5) Alternating composition |
- AIRE
- DIDO1
- GRLF1
- ING
- JARID
- JMJD1B
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| (2.6) WRKY |
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(3) Helix-turn-helix domains
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(4) β-Scaffold factors with minor groove contacts
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| (4.1) Rel homology region |
- NF-κB
- NFKB1
- NFKB2
- REL
- RELA
- RELB
- NFAT
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| (4.2) STAT |
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| (4.3) p53 |
- p53
- TBX
- 1
- 2
- 3
- 5
- 19
- 21
- 22
- TBR1
- TBR2
- TFT
- MYRF
- TP63
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| (4.4) MADS box |
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| (4.6) TATA-binding proteins |
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| (4.7) High-mobility group |
- BBX
- HMGB
- HMGN
- HNF
- LEF1
- SOX
- 1
- 2
- 3
- 4
- 5
- 6
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 18
- 21
- SRY
- SSRP1
- TCF
- TOX
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| (4.9) Grainyhead |
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| (4.10) Cold-shock domain |
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| (4.11) Runt |
- CBF
- CBFA2T2
- CBFA2T3
- RUNX1
- RUNX2
- RUNX3
- RUNX1T1
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(0) Other transcription factors
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| (0.2) HMGI(Y) |
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| (0.3) Pocket domain |
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| (0.5) AP-2/EREBP-related factors |
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| (0.6) Miscellaneous |
- ARID
- CAP
- IFI
- MLL
- MNDA
- NFY
- Rho/Sigma
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see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Structural mechanisms of DREAM complex assembly and regulation.
- Guiley KZ1, Liban TJ1, Felthousen JG2, Ramanan P1, Litovchick L3, Rubin SM4.
- Genes & development.Genes Dev.2015 May 1;29(9):961-74. doi: 10.1101/gad.257568.114. Epub 2015 Apr 27.
- The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130. Upon cell cycle entry, MuvB dissociates from p107/p130 and recruits B-Myb and FoxM1 for up-regulating mitotic gene expression. To understand
- PMID 25917549
- pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer.
- Cito L1, Indovina P, Forte IM, Pentimalli F, Di Marzo D, Somma P, Barone D, Penon A, Penon D, Ceccherini E, Micheli P, Saragoni L, Di Domenico M, Feola A, Roviello F, Mattioli E, Giordano GG, Giordano A.
- Journal of cellular physiology.J Cell Physiol.2015 Apr;230(4):802-5. doi: 10.1002/jcp.24805.
- pRb2/p130 is a key tumor suppressor, whose oncosuppressive activity has mainly been attributed to its ability to negatively regulate cell cycle by interacting with the E2F4 and E2F5 transcription factors. Indeed, pRb2/p130 has been found altered in various cancer types in which it functions as a val
- PMID 25205458
- The DREAM complex promotes gene body H2A.Z for target repression.
- Latorre I1, Chesney MA1, Garrigues JM2, Stempor P1, Appert A1, Francesconi M3, Strome S2, Ahringer J4.
- Genes & development.Genes Dev.2015 Mar 1;29(5):495-500. doi: 10.1101/gad.255810.114.
- The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of l
- PMID 25737279
Japanese Journal
- The retinoblastoma-like protein p130 is involved in the determination of reserve cells in differentiating myoblasts
Related Links
- Gene ID: 5934, updated on 3-Apr-2014 Summary Other designations 130 kDa retinoblastoma-associated protein, PRB2, RBR-2, retinoblastoma-like protein 2, retinoblastoma-related protein 2 GeneRIFs: Gene References ...
- Retinoblastoma-like protein 2 Alternative name(s): 130 kDa retinoblastoma-associated protein Short name: p130 Retinoblastoma-related protein 2 Short name: RBR-2 pRb2 Gene names i Name:RBL2 Synonyms: RB2 Organism i i ...
Related Pictures
★リンクテーブル★
[★]
[★]
- 英
- retinoblastoma-like protein p130
[★]
- 関
- alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such