WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
malignant ocular tumor of retinal cells; usually occurs before the third year of life; composed of primitive small round retinal cells
found pleasant or attractive; often used as a combining form; "a well-liked teacher"

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
蛋白(たんばく)質
(…の)『好み』,趣味《+『for』(『to』)+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/05 18:04:53」(JST)

wiki en

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.^[1]^[2]

Function

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.^[1]

Interactions

Retinoblastoma-like protein 1 has been shown to interact with:

BEGAIN,^[3]
BRCA1,^[4]
BRF1,^[5]
Cyclin A2,^[6]^[7]
Cyclin-dependent kinase 2,^[8]^[9]
E2F1,^[6]
HDAC1,^[10]^[11]
MYBL2^[7]^[12]
Mothers against decapentaplegic homolog 3,^[13]
Prohibitin,^[14] and
RBBP8.^[15]^[3]

References

^ ^a ^b "Entrez Gene: RBL1 retinoblastoma-like 1 (p107)".
^ Ewen ME, Xing YG, Lawrence JB, Livingston DM (Sep 1991). "Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein". Cell 66 (6): 1155–64. doi:10.1016/0092-8674(91)90038-Z. PMID 1833063.
^ ^a ^b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
^ Fan S, Yuan R, Ma YX, Xiong J, Meng Q, Erdos M, Zhao JN, Goldberg ID, Pestell RG, Rosen EM (Aug 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene 20 (35): 4827–41. doi:10.1038/sj.onc.1204666. PMID 11521194.
^ Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ (Jun 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Molecular and Cellular Biology 19 (6): 4255–61. PMC 104385. PMID 10330166.
^ ^a ^b Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (Dec 1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1". Journal of Virology 67 (12): 7641–7. PMC 238233. PMID 8230483.
^ ^a ^b Joaquin M, Bessa M, Saville MK, Watson RJ (Nov 2002). "B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107". Oncogene 21 (52): 7923–32. doi:10.1038/sj.onc.1206001. PMID 12439743.
^ Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (Feb 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Molecular and Cellular Biology 19 (2): 1460–9. PMC 116074. PMID 9891079.
^ Leng X, Noble M, Adams PD, Qin J, Harper JW (Apr 2002). "Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4". Molecular and Cellular Biology 22 (7): 2242–54. PMC 133692. PMID 11884610.
^ Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE (Oct 1999). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Molecular and Cellular Biology 19 (10): 6632–41. PMC 84642. PMID 10490602.
^ Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United States of America 95 (18): 10493–8. PMC 27922. PMID 9724731.
^ Joaquin M, Watson RJ (Nov 2003). "The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain". The Journal of Biological Chemistry 278 (45): 44255–64. doi:10.1074/jbc.M308953200. PMID 12947099.
^ Chen CR, Kang Y, Siegel PM, Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell 110 (1): 19–32. PMID 12150994.
^ Wang S, Nath N, Adlam M, Chellappan S (Jun 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. PMID 10376528.
^ Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

RBL1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 網膜芽細胞腫の概要 overview of retinoblastoma
2. 白色瞳孔を有する小児に対するアプローチ approach to the child with leukocoria
3. 前立腺癌の分子生物学 molecular biology of prostate cancer
4. 黒色腫（メラノーマ）に対する遺伝的感受性 inherited susceptibility to melanoma
5. 多発性骨髄腫の病理生物学 pathobiology of multiple myeloma

English Journal

Regulation of the retinoblastoma-E2F pathway by the ubiquitin-proteasome system.

Sengupta S1, Henry RW2.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Oct;1849(10):1289-97. doi: 10.1016/j.bbagrm.2015.08.008. Epub 2015 Aug 28.
The retinoblastoma tumor suppressor (RB) and its related family members p107 and p130 regulate cell proliferation through the transcriptional repression of genes involved in cellular G1 to S phase transition. However, RB proteins are functionally versatile, and numerous genetic and biochemical studi
PMID 26319102

Structural mechanisms of DREAM complex assembly and regulation.

Guiley KZ1, Liban TJ1, Felthousen JG2, Ramanan P1, Litovchick L3, Rubin SM4.
Genes & development.Genes Dev.2015 May 1;29(9):961-74. doi: 10.1101/gad.257568.114. Epub 2015 Apr 27.
The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins with E2F4/5 and the Rb tumor suppressor paralog p107 or p130. Upon cell cycle entry, MuvB dissociates from p107/p130 and recruits B-Myb and FoxM1 for up-regulating mitotic gene expression. To understand
PMID 25917549

Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins.

Vilas JM1, Ferreirós A1, Carneiro C2, Morey L3, Da Silva-Álvarez S1, Fernandes T2, Abad M4, Di Croce L3,5, García-Caballero T6, Serrano M4, Rivas C7,8, Vidal A2, Collado M1.
Oncotarget.Oncotarget.2015 Feb 20;6(5):2992-3002.
Cellular reprogramming to iPSCs has uncovered unsuspected links between tumor suppressors and pluripotency factors. Using this system, it was possible to identify tumor suppressor p27 as a repressor of Sox2 during differentiation. This led to the demonstration that defects in the repression of Sox2
PMID 25576924

「RBL1」

Retinoblastoma-like 1
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1H28, 4YOO
Identifiers
Symbols	RBL1 ; CP107; PRB1; p107
External IDs	OMIM: 116957 MGI: 103300 HomoloGene: 2172 GeneCards: RBL1 Gene
Gene ontology
Molecular function	• protein binding; • transcription factor binding;
Cellular component	• nucleus; • nucleoplasm; • transcription factor complex;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • mitotic cell cycle; • transcription, DNA-templated; • transcription initiation from RNA polymerase II promoter; • transforming growth factor beta receptor signaling pathway; • gene expression; • viral process; • chromatin modification; • regulation of lipid kinase activity; • positive regulation of transcription from RNA polymerase II promoter; • regulation of cell cycle;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;