関: retinal ischaemia

WordNet

in or relating to the retina of the eye; "retinal cells"
the innermost light-sensitive membrane covering the back wall of the eyeball; it is continuous with the optic nerve
local anemia in a given body part sometimes resulting from vasoconstriction or thrombosis or embolism (同)ischaemia

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/14 09:17:48」(JST)

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Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic arterial hypoperfusion to the eye.^[1] Amaurosis fugax is a form of acute vision loss caused by reduced blood flow to the eye that may be a warning sign of an impending stroke. Consequently, those with transient blurring of vision are advised to urgently seek medical attention for a thorough evaluation of the carotid artery. Anterior segment ischemic syndrome is a similar ischemic condition of anterior segment usually seen in post-surgical cases. Retinal arterial occlusion leads to rapid death of retinal cells, thereby resulting in severe loss of vision.

Symptoms and signs

Those with ocular ischemic syndrome are typically between the ages of 50 and 80 (patients over 65) ;^[2]^[3] twice as many men as women are affected.^[3] More than 90% of those presenting with the condition have vision loss.^[1] Patients may report a dull, radiating ache over the eye and eyebrow.^[1] Those with ocular ischemic syndrome may also present with a history of other systemic diseases including arterial hypertension, diabetes mellitus, coronary artery disease, previous stroke, and hemodialysis.^[4]^[5]

The condition presents with visual loss secondary to hypoperfusion of the eye structures. The patient presents with intractable pain or ocular angina. On dilated examination, there may be blot retinal hemorrhages along with dilated and beaded retinal veins. The ocular perfusion pressure is decreased. The corneal layers show edema and striae. There is mild anterior uveitis. A cherry-red spot in macula may be seen, along with cotton-wool spots elsewhere, due to retinal nerve fiber layer hemorrhages. The retinal arteries may show spontaneous pulsations.

Causes

Severe ipsilateral or bilateral carotid artery stenosis or occlusion is the most common cause of ocular ischemic syndrome.^[1] The syndrome has been associated with occlusion of the common carotid artery, internal carotid artery, and less frequently the external carotid artery.^[6] Other causes include:

Takayasu's arteritis^[7]
Giant cell arteritis^[8]
Severe ophthalmic artery occlusion, due to thromboembolism.
Surgical interruption of anterior ciliary blood vessels supplying the eye, particularly during extensive strabismus surgery on 3 or more rectus muscles, leading to an anterior segment ischemic syndrome.

Complications

If carotid occlusive disease results in ophthalmic artery occlusion, general ocular ischemia may result in retinal neovascularization, rubeosis iridis, cells and flare, iris necrosis, and cataract. The condition leads to neovascularization in various eye tissues due to the ischemia. The eye pressure may become high due to associated neovascular glaucoma. An ischemic optic neuropathy may eventually occur.

Treatment and management

Quick determination of the cause may lead to urgent measures to save the eye and life of the patient. High clinical suspicion should be kept for painless vision loss in patients with atherosclerosis, deep venous thrombosis, atrial fibrillation, pulmonary thromboembolism or other previous embolic episodes. Those caused by a carotid artery embolism or occlusion have the potential for further stroke by detachment of embolus and migration to an end-artery of the brain.^[9] Hence, proper steps to prevent such an eventuality need to be taken.

Retinal arterial occlusion is an ophthalmic emergency, and prompt treatment is essential. Completely anoxic retina in animal models causes irreversible damage in about 90 minutes. Nonspecific methods to increase blood flow and dislodge emboli include digital massage, 500 mg IV acetazolamide and 100 mg IV methylprednisolone (for possible arteritis). Additional measures include paracentesis of aqueous humor to decrease IOP acutely. An ESR should be drawn to detect possible giant cell arteritis. Improvement can be determined by visual acuity, visual field testing, and by ophthalmoscopic examination.

At a later stage, pan-retinal photocoagulation (PRP) with an argon laser appears effective in reducing the neovascular components and their sequelae.

The visual prognosis for ocular ischemic syndrome varies from usually poor to fair, depending on speed and effectiveness of the intervention. However, prompt diagnosis is crucial as the condition may be a presenting sign of serious cerebrovascular and ischemic heart diseases.^[5]

In 2009, the Undersea and Hyperbaric Medical Society added "central retinal artery occlusion" to their list of approved indications for hyperbaric oxygen (HBO).^[10]^[11] When used as an adjunctive therapy, the edema reducing properties of HBO, along with down regulation of inflammatory cytokines may contribute to the improvement in vision.^[12] Prevention of vision loss requires that certain conditions be met: the treatment be started before irreversible damage has occurred (over 24 hours), the occlusion must not also occur at the ophthalmic artery, and treatment must continue until the inner layers of the retina are again oxygenated by the retinal arteries.^[13]

Differential diagnoses

Central retinal vein occlusion
Diabetic retinopathy: The presence of retinal hemorrhages, particularly in those who have diabetes, may also be caused by diabetic retinopathy.^[14] Given the bilateral nature of diabetic retinopathy, however, one should suspect ocular ischemic syndrome when retinal ischemia is unilateral.^[15]

References

^ ^a ^b ^c ^d De Graeve C, Van de Sompel W, Claes C. "Ocular ischemic syndrome: two case reports of bilateral involvement." Bull Soc Belge Ophtalmol. 1999;273:69-74. PMID 10546383.
^ Friedberg MA, Rapuano CJ. The Wills Eye Manual: Office and Emergency Room Diagnosis and Treatment of Eye Disease, J.B. Lippincott, 1994.
^ ^a ^b "Ocular Ischemic Syndrome." Accessed October 25, 2006.
^ Chen KJ, Chen SN, Kao LY, Ho CL, Chen TL, Lai CC, Wu SC. (August 2001). "Ocular ischemic syndrome". Chang Gung Medical Journal 24 (8): 483–91. PMID 11601190.
^ ^a ^b Mizener JB, Podhajsky P, Hayreh SS (May 1997). "Ocular ischemic syndrome". Ophthalmology 104 (5): 859–64. doi:10.1016/s0161-6420(97)30221-8. PMID 9160035.
^ Alizai AM, Trobe JD, Thompson BG, Izer JD, Cornblath WT, Deveikis JP (December 2005). "Ocular ischemic syndrome after occlusion of both external carotid arteries". Journal of Neuro-Ophthalmology 25 (4): 268–72. doi:10.1097/01.wno.0000189831.92504.2d. PMID 16340491. Retrieved 2009-05-26.
^ Koz OG, Ates A, Numan Alp M, Gultan E, Karaaslan Y, Kural G (January 2007). "Bilateral ocular ischemic syndrome as an initial manifestation of Takayasu's arteritis associated with carotid steal syndrome". Rheumatology International 27 (3): 299–302. doi:10.1007/s00296-006-0194-4. PMID 16944156. |accessdate= requires |url= (help)
^ Hamed LM, Guy JR, Moster ML, Bosley T (June 1992). "Giant cell arteritis in the ocular ischemic syndrome". American Journal of Ophthalmology 113 (6): 702–5. PMID 1598963.
^ Kaiboriboon K, Piriyawat P, Selhorst JB (May 2001). "Light-induced amaurosis fugax". American Journal of Ophthalmology 131 (5): 674–6. doi:10.1016/S0002-9394(00)00874-6. PMID 11336956. Retrieved 2009-05-26.
^ The Undersea and Hyperbaric Medical Society (UHMS), Hyperbaric Oxygen Therapy Committee. Guidelines: Indications for Hyperbaric Oxygen. Durham, NC: UHMS; 2009.
^ Butler FK, Hagan C, Murphy-Lavoie H (2008). "Hyperbaric oxygen therapy and the eye". Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 35 (5): 333–87. PMID 19024664. Retrieved 2010-11-09.
^ Wright JK, Franklin B, Zant E (2007). "Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen". Undersea and Hyperbaric Medicine 34 (5): 315–9. PMID 18019081. Retrieved 2009-05-26.
^ Butler Jr, FK (2010). "Hyperbaric oxygen for central retinal artery occlusion". Wound Care & Hyperbaric Medicine 1 (3): 25.
^ Munch IC, Larsen M (Aug 2005). "[The ocular ischemic syndrome.]". Ugeskr Laeger 167 (35): 3269–73. PMID 16138965.
^ Bigou MA, Bettembourg O, Hebert T, Cochener B (Jan 2006). "[Unilateral ocular ischemic syndrome in a diabetic patient.]". J Fr Ophtalmol 29 (1): e2. PMID 16465117.

UpToDate Contents

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English Journal

Activation of ERK pathway is required for 15-HETE-induced angiogenesis in human umbilical vascular endothelial cells.

Wang S1, Cao W1, Xing H1, Chen YL2, Li Q1, Shen T1, Jiang C1,3, Zhu D1,2.
Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Jun;36(3):225-32. doi: 10.3109/10799893.2015.1077865. Epub 2015 Oct 13.
Angiogenesis plays a critical role in the progression of cardiovascular disease, retinal ischemia, or tumorigenesis. The imbalance of endothelial cell proliferation and apoptosis disturbs the establishment of the vasculogenesis, which is affected by several arachidonic acid metabolites. 15-Hydroxyei
PMID 26460784

Inhibiting Matrix Metalloproteinase 3 Ameliorates Neuronal Loss in the Ganglion Cell Layer of Rats in Retinal Ischemia/Reperfusion.

Hu T1, You Q2, Chen D1, Tong J3, Shang L1, Luo J1, Qiu Y2, Yu H4, Zeng L5, Huang J6.
Neurochemical research.Neurochem Res.2016 May;41(5):1107-1118. Epub 2016 Jan 30.
It has been demonstrated that matrix metalloproteinase 3 (MMP3) is integrally involved in the neuronal degeneration of the central nervous system by promoting glial activation, neuronal apoptosis and damage to the brain-blood barrier. However, whether MMP3 also contributes to the neuronal degenerati
PMID 26830289

Assessment of Ischemic Index in Retinal Vascular Diseases Using Ultra-Wide-Field Fluorescein Angiography: Single Versus Summarized Image.

Franco-Cardenas V1, Shah SU1, Apap D1, Joseph A1, Heilweil G1, Zutis K2, Trucco E2, Hubschman JP1.
Seminars in ophthalmology.Semin Ophthalmol.2016 Apr 14:0. [Epub ahead of print]
BACKGROUND AND OBJECTIVE: To compare a single image with a computer-generated summarized image from the ultra-wide-field fluorescein angiogram (UWFFA) sequence for evaluation of ischemic index (ISI).MATERIALS AND METHODS: UWFFA sequences from patients with diabetic retinopathy (DR) (n=5), branch ret
PMID 27077942

Japanese Journal

LABORATORY INVESTIGATION : Possible implications of acid-sensing ion channels in ischemia-induced retinal injury in rats

Miyake Takatomo,Nishiwaki Akiko,Yasukawa Tsutomu [他]
Japanese journal of ophthalmology : the official English-language journal of the Japanese Ophthalmological Society 57(1), 120-125, 2013-01
NAID 40019546548

The Neuroprotective Effects of Lidocaine and Methylprednisolone in a Rat Model of Retinal Ischemia-Reperfusion Injury

TASI Wen-Chih,M. PETERSEN-JONES Simon,HUANG Pei-Yun [他]
The journal of veterinary medical science 74(3), 307-313, 2012-03
NAID 40019249076

The Neuroprotective Effects of Lidocaine and Methylprednisolone in a Rat Model of Retinal Ischemia-Reperfusion Injury

TASI Wen-Chih,PETERSEN-JONES Simon M.,HUANG Pei-Yun,LIN Chung-Tien
Journal of Veterinary Medical Science 74(3), 307-313, 2012
… Retinal ischemia is a common cause of visual impairment for humans and animals. … The neuroprotective effects of lidocaine (LDC) and methylprednisolone (MP) upon retinal ischemic injury were investigated in a rat model. … A very high intraocular pressure (HIOP) and retinal ischemia were induced. …
NAID 130001190500