reserpine poisoning

レセルピン中毒

WordNet

1. the physiological state produced by a poison or other toxic substance (同)toxic condition, intoxication
2. the act of giving poison to a person or animal with the intent to kill
3. antihypertensive consisting of an alkaloid extracted from the plant Rauwolfia serpentina (trade names Raudixin or Rau-Sed or Sandril or Serpasil) (同)Raudixin, Rau-Sed, Sandril, Serpasil

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English Journal

• Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine.

• Santos JR1, Cunha JA, Dierschnabel AL, Campêlo CL, Leão AH, Silva AF, Engelberth RC, Izídio GS, Cavalcante JS, Abílio VC, Ribeiro AM, Silva RH.
• Behavioural brain research.Behav Brain Res.2013 Sep 15;253:68-77. doi: 10.1016/j.bbr.2013.06.031. Epub 2013 Jul 3.
• Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's disease (PD). However, in general, classic animal models are based on severe motor impairment after one single administration of neurotoxins, and thereby do not express the progressive nature of the pathology
• PMID 23831411

• The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease.

• Johnson KA1, Jones CK, Tantawy MN, Bubser M, Marvanova M, Ansari MS, Baldwin RM, Conn PJ, Niswender CM.
• Neuropharmacology.Neuropharmacology.2013 Mar;66:187-95. doi: 10.1016/j.neuropharm.2012.03.029. Epub 2012 Apr 21.
• Metabotropic glutamate receptors (mGlus) are 7 Transmembrane Spanning Receptors (7TMs) that are differentially expressed throughout the brain and modulate synaptic transmission at both excitatory and inhibitory synapses. Recently, mGlus have been implicated as therapeutic targets for many disorders
• PMID 22546615

• Gallic acid decreases vacuous chewing movements induced by reserpine in rats.

• Reckziegel P1, Peroza LR, Schaffer LF, Ferrari MC, de Freitas CM, Bürger ME, Fachinetto R.
• Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2013 Mar;104:132-7. doi: 10.1016/j.pbb.2013.01.001. Epub 2013 Jan 11.
• Involuntary oral movements are present in several diseases and pharmacological conditions; however, their etiology and efficient treatments remain unclear. Gallic acid is a natural polyphenolic acid found in gall nuts, sumac, oak bark, tea leaves, grapes and wine, with potent antioxidant and antiapo
• PMID 23313549

Related Links

• Reserpine (PIM 467) - IPCS INCHEM

1. NAME 1.1 Substance Reserpine 1.2 Group Antihypertensive 1.3 Synonyms Reserpinium 1.4 Identification numbers 1.4.1 CAS number 50-55-5 1.4.2 Other numbers 1.5 Brand names, Trade names Serpalan Serpasil ...

• Reserpine - FDA prescribing information, side effects and uses

No deaths due to acute poisoning with Reserpine have been reported. Highest known doses survived: children, 1000 mg (age and sex not specified); young children, 200 mg (20-month-old boy). Oral LD 50 's in animals (mg/kg): rat ...