WordNet
- (psychiatry) the classical defense mechanism that protects you from impulses or ideas that would cause anxiety by preventing them from becoming conscious
- a state of forcible subjugation; "the long repression of Christian sects"
- the act of repressing; control by holding down; "his goal was the repression of insolence"
- any specific behavior; "they avoided all recreational activity"
- (chemistry) the capacity of a substance to take part in a chemical reaction; "catalytic activity"
PrepTutorEJDIC
- 鎮圧すること,抑圧された状態 / (意識の)抑圧
- 〈U〉『活動』,働き;活力 / 《しばしば複数形で》(種々の)『活動』,行事;(学生の)学内(外)活動,クラブ活動 / 〈U〉(商況・市場などの)活発,活気
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- 1. 性行為に伴う一次性頭痛 primary headache associated with sexual activity
- 2. 臨床試験および臨床における関節リウマチの活動性の評価 assessment of rheumatoid arthritis activity in clinical trials and clinical practice
- 3. 心血管疾患患者における性的活動 sexual activity in patients with cardiovascular disease
- 4. 低カリウム血症を合併した高血圧症へのアプローチ approach to the patient with hypertension and hypokalemia
- 5. 癌生存における食事、身体活動、および体重の役割 the roles of diet physical activity and body weight in cancer survivorship
English Journal
- Novel Treatment of Acute Promyelocytic Leukemia: As2O3, Retinoic Acid and Retinoid Pharmacology.
- Zhu G, Mische SE, Seigneres B.Author information Institute of Oncology of George Zhu, 422407, Beijing, China. sansan4240732@163.com.AbstractAcute promyelocytic leukemia(APL), a specific characteristic of t(15;17) chromosome translocation, represents 5% to 15% of cases of acute nonlymphocytic leukemia. An alternative approach is to consider retinoic acid(all-trans RA, ATRA or 13-cis RA or 9-cis RA) plus chemotherapy or RA plus As2O3 regimens as now novel therapy. Molecular gene analyses are conclusive in vivo evidence that oncogenic PML/RARa plays a crucial role in APL leukemogenesis. As a novel approach to APL treatment, one possible the action of RA, A consense sequence (5'-TCAGGTCATGACCTGA-3') has been postulated for the thyroid hormone (TRE) and retinoic acid responsive element (RARE) containing half palindromes, which located in the promoter region of target genes. High dose (100-fold) of RA-RARE-PML/RARa complex in intracellular localization appears to relieve repressor from DNA binding, including corepressors N-CoR, SMRT and HDACs, release PML/RARa- mediated transcriptional repression, and release histone deacetylase activity from PMLRARa. The resulting PML/RARa oncoprotein proteolytic degradation through the autophagy-lysosome pathway and the ubiquitin SUMO-proteasome system (UPS), as well as caspase 3 (cleavage site Asp522 within a-helics region of PML component of the fusion protein) or neutrophil elastase, or lysosomal protease enzyme induction. PML protein relocalizes into the wild-type nuclear body (PML-NB) configuration or/and wild-type RARa upregulated. An effect to relieve the blockade (inhibition) of PML/RARA-mediated RA dependent promyelocytic differentiation, and retinoic acid in APL therapy (see Figure in the full text, George Zhu, 1991). Here, like v-erbA, PML/RARa is a (strong) transcriptional repressor of the RA receptor (RAR) complex, and PML/RARa fusion receptor gene act as conditional oncogenic receptor (translocated chimeric retinoic acid a signaling) or oncogenic PML/RARa may participate in leukemogenesis of APL through blocking RA-mediated promyelocytic differentiation. This is first described in eukaryotes.
- Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Oct;14(9):849-58.
- Acute promyelocytic leukemia(APL), a specific characteristic of t(15;17) chromosome translocation, represents 5% to 15% of cases of acute nonlymphocytic leukemia. An alternative approach is to consider retinoic acid(all-trans RA, ATRA or 13-cis RA or 9-cis RA) plus chemotherapy or RA plus As2O3 regi
- PMID 24433507
- Chemiluminescence resonance energy transfer biosensing platform for site-specific determination of DNA methylation and assay of DNA methyltransferase activity using exonuclease III-assisted target recycling amplification.
- Chen C1, Li B2.Author information 1Key laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China.2Key laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China. Electronic address: libaoxin@snnu.edu.cn.AbstractSite-specific determination of DNA methylation and assay of MTase activity can be used for determining specific cancer types, providing insights into the mechanism of gene repression, and developing novel drugs to treat methylation-related diseases. Herein, we develop a simple and highly sensitive chemiluminescence (CL) biosensing platform for site-specific determination of DNA methylation using Exonuclease III (Exo III)-assisted target recycling signal amplification. After bisulfite treatment of mixture of methylated DNA and unmethylated DNA, methylated DNA can hybridize with fluorescein (FAM)-labeled probe DNA to form double-stranded DNA (dsDNA), removing the FAM-labeled probe DNA from the surface of grapheme oxide, and the chemiluminescence resonance energy transfer (CRET) sensing signal can be observed and then amplified using Exo III-based recycling strategy. The biosensing platform exhibits excellent high sensitivity, and it can ever distinguish as low as 0.002% methylation level from the mixture, which is superior to most currently reported methods used for DNA methylation assay. In addition, the proposed method can also be used to sensitively assay MTase activity with determination limit of 0.007U/mL. This CL biosensing offers the advantages of being facile, sensitive, rapid and cost-effective. These features make the system promising for future use for early cancer diagnosis and discover of new anticancer drugs.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:48-54. doi: 10.1016/j.bios.2013.10.050. Epub 2013 Oct 31.
- Site-specific determination of DNA methylation and assay of MTase activity can be used for determining specific cancer types, providing insights into the mechanism of gene repression, and developing novel drugs to treat methylation-related diseases. Herein, we develop a simple and highly sensitive c
- PMID 24240168
- Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.
- Hang D, Gao L, Sun M, Liu Y, Ke Y.Author information Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Genetics, Peking University Cancer Hospital & Institute, Beijing, China.AbstractSequence variations within the genome of human papillomavirus (HPV) type 16 have been reported in different ethnic populations, with some evidence suggesting that non-European variants may confer higher oncogenic potential. HPV16 European (EUR) and Asian (As) variants were identified previously as two major variants in cervical cancer from Anyang, China. The evolutionary analysis of these variants revealed that several important sequence variations in the E6 and E2 genes were under positive selection pressure. The aim of this study was to evaluate the effects of these variations on E6 and E2 functions regarding p53 degradation and transcription regulation of the long control region (LCR). By Western blot analysis, a similar ability to degrade p53 was observed among EUR E6, As E6, EUR E6-L83V and As E6-E113D. A rare variation, EUR E6-R10G, was found to shorten the half-life of p53 more efficiently than the other variations. Unlike EUR E2 acting as a transcriptional activator or a repressor at different concentrations, As E2 showed a dose-dependent repression of LCR activity, about twofold stronger than EUR E2 in the luciferase reporter assays. Furthermore, the site-directed mutagenesis revealed that E232K, which is a linked variation in the hinge region of As E2, was responsible for its enhanced repression ability. Collectively, these data indicate the altered functions of HPV16 E6 and E2 by certain variations, which may influence the potential of viral carcinogenesis. J. Med. Virol. 86:618-626, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of medical virology.J Med Virol.2014 Apr;86(4):618-26. doi: 10.1002/jmv.23792. Epub 2013 Oct 22.
- Sequence variations within the genome of human papillomavirus (HPV) type 16 have been reported in different ethnic populations, with some evidence suggesting that non-European variants may confer higher oncogenic potential. HPV16 European (EUR) and Asian (As) variants were identified previously as t
- PMID 24150786
Japanese Journal
- Inhibitory effect of Cinnamomum osmophloeum Kanehira ethanol extracts on melanin synthesis via repression of tyrosinase expression
- Journal of bioscience and bioengineering 122(3), 263-269, 2016-09
- NAID 40020949758
- Auxin-dependent compositional change in Mediator in ARF7- and ARF19-mediated transcription
- 2016-05-23
- NAID 120005764289
- A Maternal System Initiating the Zygotic Developmental Program through Combinatorial Repression in the Ascidian Embryo
- PLoS Genetics 12(5), 2016-05-01
- NAID 120005774655
Related Links
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★リンクテーブル★
| リンク元 | 「抑制活性」「inhibitory potency」「inhibitory activity」 |
| 関連記事 | 「activity」 |
「抑制活性」
「inhibitory potency」
「inhibitory activity」
「activity」
- n.
- 関
- active