English Journal

Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae.

Lord CL1, Timney BL2, Rout MP2, Wente SR3.
The Journal of cell biology.J Cell Biol.2015 Mar 16;208(6):729-44. doi: 10.1083/jcb.201412024.
The eukaryotic nuclear permeability barrier and selective nucleocytoplasmic transport are maintained by nuclear pore complexes (NPCs), large structures composed of ∼ 30 proteins (nucleoporins [Nups]). NPC structure and function are disrupted in aged nondividing metazoan cells, although it is uncle
PMID 25778920

Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.

He C1, Tsuchiyama SK1, Nguyen QT2, Plyusnina EN3, Terrill SR2, Sahibzada S2, Patel B1, Faulkner AR1, Shaposhnikov MV3, Tian R1, Tsuchiya M1, Kaeberlein M4, Moskalev AA5, Kennedy BK1, Polymenis M2.
PLoS genetics.PLoS Genet.2014 Dec 18;10(12):e1004860. doi: 10.1371/journal.pgen.1004860. eCollection 2014.
The common non-steroidal anti-inflammatory drug ibuprofen has been associated with a reduced risk of some age-related pathologies. However, a general pro-longevity role for ibuprofen and its mechanistic basis remains unclear. Here we show that ibuprofen increased the lifespan of Saccharomyces cerevi
PMID 25521617

The basic helix-loop-helix/leucine zipper transcription factor USF2 integrates serum-induced PAI-1 expression and keratinocyte growth.

Qi L1, Higgins CE, Higgins SP, Law BK, Simone TM, Higgins PJ.
Journal of cellular biochemistry.J Cell Biochem.2014 Oct;115(10):1840-7. doi: 10.1002/jcb.24861.
Plasminogen activator inhibitor type-1 (PAI-1), a major regulator of the plasmin-dependent pericellular proteolytic cascade, is prominently expressed during the tissue response to injury although the factors that impact PAI-1 induction and their role in the repair process are unclear. Kinetic modeli
PMID 24905330

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