replication protein A

複製タンパク質A

WordNet

1. (genetics) the process whereby DNA makes a copy of itself before cell division
2. the repetition of an experiment in order to test the validity of its conclusion; "scientists will not believe an experimental result until they have seen at least one replication"
3. (law) a pleading made by a plaintiff in reply to the defendants plea or answer
4. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
5. the 1st letter of the Roman alphabet (同)a
6. the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

1. 写し,複写,複製 / 《文》(被告の訴答に対する)原告の訴答
2. 蛋白(たんばく)質
3. answer / ampere
4. arsenicの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/26 12:04:29」(JST)

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Replication protein A C terminal
Identifiers
Symbol	RPA_C
Pfam	PF08784
InterPro	IPR014892
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Replication protein A (RPA) is a protein that binds to single-stranded DNA in eukaryotic cells. During DNA replication, RPA prevents single-stranded DNA (ssDNA) from winding back on itself or from forming secondary structures. This keeps DNA unwound for the polymerase to replicate it. RPA also binds to ssDNA during the initial phase of homologous recombination, an important process in DNA repair and prophase I of meiosis. Like its role in DNA replication, this keeps ssDNA from binding to itself (self-complementizing) so that the resulting nucleoprotein filament can then bound by Rad51 and its cofactors. RPA also binds to DNA during the Nucleotide Excision Repair process. This binding stabilizes the repair complex during the repair process. A bacterial homolog is called single-strand binding protein (SSB).

Structure

RPA is a heterotrimer, composed of the subunits RPA1 (70kDa subunit), RPA2 (32kDa subunit) and RPA3 (14kDa subunit). The three RPA subunits contain OB-folds (oligonucleotide/oligosaccharide binding).

References

UpToDate Contents

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• 5. エプスタインバーウイルス（EBウイルス）のウイルス学 virology of epstein barr virus

English Journal

• Metal binding mediated conformational change of XPA protein:a potential cytotoxic mechanism of nickel in the nucleotide excision repair.

• Hu J1,2,3, Hu Z2, Zhang Y2, Gou X3, Mu Y4, Wang L5,6, Xie XQ7,8.
• Journal of molecular modeling.J Mol Model.2016 Jul;22(7):156. doi: 10.1007/s00894-016-3017-x. Epub 2016 Jun 16.
• Nucleotide excision repair (NER) is a pivotal life process for repairing DNA nucleotide mismatch caused by chemicals, metal ions, radiation, and other factors. As the initiation step of NER, the xeroderma pigmentosum complementation group A protein (XPA) recognizes damaged DNA molecules, and recruit
• PMID 27307058

• CTF18 interacts with replication protein A in response to replication stress.

• Kaneko Y1, Daitoku H1, Komeno C1, Fukamizu A1.
• Molecular medicine reports.Mol Med Rep.2016 Jul;14(1):367-72. doi: 10.3892/mmr.2016.5262. Epub 2016 May 13.
• Replication stress response is a protective mechanism against defects in chromosome replication for maintaining genome integrity in eukaryotic cells. An alternative clamp loader complex termed chromosome transmission fidelity protein 18 and replication factor C (CTF18‑RFC) has been shown to act a
• PMID 27175616

• Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage.

• Acevedo J1, Yan S2, Michael WM3.
• The Journal of biological chemistry.J Biol Chem.2016 Jun 17;291(25):13124-31. doi: 10.1074/jbc.M116.729194. Epub 2016 Apr 26.
• A critical event for the ability of cells to tolerate DNA damage and replication stress is activation of the ATR kinase. ATR activation is dependent on the BRCT (BRCA1 C terminus) repeat-containing protein TopBP1. Previous work has shown that recruitment of TopBP1 to sites of DNA damage and stalled
• PMID 27129245

Japanese Journal

• Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

• PLOS Pathogens 12(1), 2016-01-06
• NAID 120005763386

• Protection from lethal herpes simplex virus type 1 infection by vaccination with a UL41-deficient recombinant strain

• FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 62(1), 36-42, 2016
• NAID 130005156335

• Akabane virus nonstructural protein NSm regulates viral growth and pathogenicity in a mouse model

• Journal of Veterinary Medical Science advpub(0), 2016
• NAID 130005150764

Related Links

• Replication protein Aとは - goo Wikipedia (ウィキペディア)

Replication protein A (RPA) is a protein that binds single-stranded DNA in eukaryotic cells. [1] During DNA replication, RPA prevents single-stranded DNA (ssDNA) from winding back on itself or from forming secondary structures.

• replication protein a

Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein involved in DNA replication, recombination and repair. In Saccharomyces cerevisiae, several mutants in the RFA1 gene encoding the large subunit of ...

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