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abnormal softening of bones caused by deficiencies of phosphorus or calcium or vitamin D

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1. 骨軟化症の疫学および病因 epidemiology and etiology of osteomalacia
2. 遺伝性低リン血症性くる病と腫瘍誘発性骨軟化症 hereditary hypophosphatemic rickets and tumor induced osteomalacia
3. 小児における、慢性腎臓病に伴う骨ミネラル代謝異常（CKD-MBD） pediatric chronic kidney disease mineral and bone disorder ckd mbd
4. 腎性骨異栄養症の骨生検および診断 bone biopsy and the diagnosis of renal osteodystrophy
5. 骨軟化症の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of osteomalacia

Pathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced by Adefovir Dipivoxil Therapy for Hepatitis B.

Lee YS1, Kim BK1, Lee HJ1, Dan J1.
Clinics in orthopedic surgery.Clin Orthop Surg.2016 Jun;8(2):232-6. doi: 10.4055/cios.2016.8.2.232. Epub 2016 May 10.
In Fanconi syndrome, hypophosphatemic osteomalacia is caused by proximal renal tubule dysfunction which leads to impaired reabsorption of amino acids, glucose, urate, and phosphate. We present a rare case of a 43-year-old Korean male who was found to have insufficiency stress fracture of the femoral
PMID 27247753

Complete resection of a large phosphaturic mesenchymal tumour by chest wall resection and reconstruction.

Okiror L1, Khalil H2, Vaiyapuri S3, Kalkat M4.
General thoracic and cardiovascular surgery.Gen Thorac Cardiovasc Surg.2016 Jun;64(6):355-8. doi: 10.1007/s11748-014-0505-8. Epub 2014 Dec 13.
Phosphaturic mesenchymal tumour is an extremely rare mesenchymal neoplasm of bone or soft tissue. It is associated with paraneoplastic oncogenic osteomalacia through secretion of fibroblast growth factor-23 (FGF-23) which inhibits renal proximal tubule phosphate re-uptake. We report a case of a 36-
PMID 25503563

Aluminum and bone: Review of new clinical circumstances associated with Al(3+) deposition in the calcified matrix of bone.

Chappard D1, Bizot P2, Mabilleau G3, Hubert L2.
Morphologie : bulletin de l'Association des anatomistes.Morphologie.2016 Jun;100(329):95-105. doi: 10.1016/j.morpho.2015.12.001. Epub 2016 Jan 4.
Several decades ago, aluminum encephalopathy associated with osteomalacia has been recognized as the major complication of chronic renal failure in dialyzed patients. Removal of aluminum from the dialysate has led to a disappearance of the disease. However, aluminum deposit occurs in the hydroxyapat
PMID 26762722

Histopathological analysis for osteomalacia and tubulopathy in itai-itai disease

Baba Hayato,Tsuneyama Koichi,Kumada Tokimasa [他]
The Journal of toxicological sciences : an official journal of the Japanese Society of Toxicology 39(1), 91-96, 2014-02
NAID 40019974910

Long-term Observation of Osteomalacia Caused by Adefovir-Induced Fanconi's Syndrome

Terasaka Tomohiro,Ueta Eijiro,Ebara Hirotaka,Waseda Koichi,Hanayama Yoshihisa,Takaki Akinobu,Kawabata Tomoko,Sugiyama Hitoshi,Hidan Ko,Otsuka Fumio
Acta Medica Okayama 68(1), 53-56, 2014-02
… Renal dysfunction,hypophosphatemia and increased levels of bone alkaline phosphatase were found. … This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconiʼs syndrome for 8 years after adefovir administration. … Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis. …
NAID 120005372647

飯塚泰弘,酒井英樹,小林小の実,飯塚和絵,伊東英里,望月奈穂子,朝比奈靖浩,渡辺守
Nippon Shokakibyo Gakkai Zasshi 111(8), 1618-1623, 2014
症例は64歳女性．B型慢性肝炎に対しLamivudineとAdefovir（ADV）を投与中に血清クレアチニン（Cre）は最高値で1.01 mg/dlと軽度上昇であったが骨痛が出現し，Fanconi症候群・骨軟化症と診断した．Entecavir（ETV）の開始，ADVの中止により軽快した後に，ETV耐性変異のためADVの少量での投与を再開し，HBV-DNAや尿細管機能を慎重に観察しコントロールを得 …
NAID 130004678085