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English Journal
- [Methylglyoxal--a test for impaired biological functions of exotrophy and endoecology, low glucose level in the cytosol and gluconeogenesis from fatty acids (a lecture)].
- Titov VN, Dmitriev LF, Krylin VA, Dmitriev VA.AbstractIn philogenesis, due to the failure to store a great deal of carbohydrates in vivo as glycogen, all animal species began synthesizing from glucose palminitic fatty acid and depositing it as triglycerides. During biological dysfunction of exotrophy (long starvation, early postnatality, hibernation), cells also accomplish a reverse synthesis of glucose from fatty acids under aerobic conditions. Under physiological conditions, acetyl-CoA that is converted to malate and pyruvate in the glyoxalate cycle is a substrate of glyconeogenesis. Under pathological conditions of hypoxia and deficiency of macroerges, gluconeogenesis occurs without ATP consumption through the methylglyoxal pathway when used as a substrate of ketone bodies via the pathway: butyric acid (butyrate) --> beta-hydroxybutyrate --> acetoacetate --> acetone --> acetol --> methylglyoxal --> S-D-lactol-glutathione --> D-lactate --> pyruvate --> D-lactate. Under physiological conditions, this gluconeogenesis pathway does not function. We believe that with low glucose levels in the cell cytosole (glycopenia), under pathological conditions of hypoxia and due to failure to mitochondria to oxidize fatty acids, gene expression and gluconeogenesis occur through the methylglyoxal pathway. At the same time, the cytosol, intercellular environment, and plasma shows the elevated levels of methylglyoxal and D-lactate that it is converted to by the action of glyoxalases I and II. Under pathological conditions, glycopenia develops in starvation, diabetes, and metabolic acidosis, neoplasms, renal failure, and possibly, metabolic syndrome. The chemical interaction of methylglyoxal with the amino acid residues of lysine and arginine results in the denaturation of circulating and structurized proteins via carbonylation--glycosylation.
- Klinicheskaia laboratornaia diagnostika.Klin Lab Diagn.2010 Mar;(3):22-36.
- In philogenesis, due to the failure to store a great deal of carbohydrates in vivo as glycogen, all animal species began synthesizing from glucose palminitic fatty acid and depositing it as triglycerides. During biological dysfunction of exotrophy (long starvation, early postnatality, hibernation),
- PMID 20737676
- Glycogen resynthesis in the absence of food ingestion during recovery from moderate or high intensity physical activity: novel insights from rat and human studies.
- Fournier PA, Bräu L, Ferreira LD, Fairchild T, Raja G, James A, Palmer TN.SourceDepartment of Human Movement and Exercise Science, The University of Western Australia, Western Australia, Crawley, Australia, 6009. fournier@cyllene.uwa.edu.au
- Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2002 Nov;133(3):755-63.
- The finding that during recovery from high intensity exercise, rats have the capacity to replenish their muscle glycogen stores even in the absence of food intake has provided us with an experimental model of choice to explore further this process. Our objective here is to share those questions aris
- PMID 12443931
Related Links
- 1. Pediatr Nephrol. 1995 Jun;9(3):287-91. Diabetes-like renal glomerular disease in Fanconi-Bickel syndrome. Berry GT, Baker L, Kaplan FS, Witzleben CL. Division of Biochemical Developmental and Molecular Diseases, Children's ...
- CLS 500 Application and Interpretation of Clinical Laboratory Data: NPN Compounds 4 19 Interpretation of BUN Values Reference range Dehydration Overhydration Impairment of GFR Severe renal impairment 5 – 20 mg/dl 20 – 26 mg ...
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- 関
- kidney、renally