関: renal glycosuria

WordNet

the presence of abnormally high levels of glucose in the urine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/29 05:55:16」(JST)

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Renal glycosuria, also known as renal glucosuria, is a rare condition in which the simple sugar glucose is excreted in the urine^[1] despite normal or low blood glucose levels. With normal kidney (renal) function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in the blood. However, in those with renal glycosuria, glucose is abnormally elevated in the urine due to improper functioning of the renal tubules, which are primary components of nephrons, the filtering units of the kidneys.

Diagnosis

A doctor normally can diagnose renal glycosuria when a routine urine test (Urinalysis) detects glucose in the urine, while a blood test indicates that the blood glucose level is normal.

Presentation

In most affected individuals, the condition causes no apparent symptoms (asymptomatic) or serious effects. When renal glycosuria occurs as an isolated finding with otherwise normal kidney function, the condition is thought to be inherited as an autosomal recessive trait^{[citation needed]}.

Genetics

It is associated with SLC5A2, coding the sodium glucose cotransporter 2.

Synonyms

Benign glycosuria
Familial renal glycosuria
Nondiabetic glycosuria
Primary renal glycosuria
Diabetes renalis
Renal diabetes
Diabetes innocence

References

^ KHACHADURIAN AK, KHACHADURIAN LA (June 1964). "THE INHERITANCE OF RENAL GLYCOSURIA". Am. J. Hum. Genet. 16: 189–94. PMC 1932305. PMID 14174800.

UpToDate Contents

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1. 遠位（I型）および近位（II型）尿細管性アシドーシスの病因および診断 etiology and diagnosis of distal type 1 and proximal type 2 renal tubular acidosis
2. 腎疾患の診断における尿検査 urinalysis in the diagnosis of renal disease
3. 尿細管性アシドーシスの概要 overview of renal tubular acidosis
4. 糖尿病のスクリーニング screening for diabetes mellitus
5. 幼児および小児における尿細管性アシドーシスの病因および臨床症状 etiology and clinical manifestations of renal tubular acidosis in infants and children

English Journal

Changes in kidney function and in the rate of tubular dysfunction after tenofovir withdrawal or continuation in HIV-infected patients.

Casado JL1, Del Rey JM, Bañón S, Santiuste C, Rodriguez M, Moreno A, Perez-Elías MJ, Liaño F, Moreno S.
Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2016 Mar 9. [Epub ahead of print]
INTRODUCTION: Longitudinal data on the changes in kidney function and tubular abnormalities in case of tenofovir disoproxil fumarate (TDF) withdrawal or continuation are scarce.METHODS: Prospective study of 228 patients receiving TDF, with 3 sequential determinations of serum creatinine, estimated g
PMID 26962850

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria.

Chhabra KH1, Adams JM2, Fagel B1, Lam DD1, Qi N3, Rubinstein M4, Low MJ5.
Diabetes.Diabetes.2016 Mar;65(3):660-72. doi: 10.2337/db15-0804. Epub 2015 Oct 14.
Hypothalamic proopiomelanocortin (POMC) is essential for the physiological regulation of energy balance; however, its role in glucose homeostasis remains less clear. We show that hypothalamic arcuate nucleus (Arc)POMC-deficient mice, which develop severe obesity and insulin resistance, unexpectedly
PMID 26467632

Bone mineral density decline according to renal tubular dysfunction and phosphaturia in tenofovir-exposed HIV-infected patients.

Casado JL1, Santiuste C, Vazquez M, Bañón S, Rosillo M, Gomez A, Perez-Elías MJ, Caballero C, Rey JM, Moreno S.
AIDS (London, England).AIDS.2016 Feb 25. [Epub ahead of print]
INTRODUCTION: The mechanisms underlying the effect of tenofovir disoproxil fumarate (TDF) on the decline of bone mineral density (BMD) have not been established, specially the effect of renal tubular dysfunction.METHODS: Longitudinal study of 90 patients with two successive dual X-ray absorptiometry
PMID 26919733

Japanese Journal

The Effect of Antioxidant on Development of Fibrosis by Cisplatin in Rats

KAWAI Yoshiko,SATOH Tomohiko,HIBI Daisuke,OHNO Yukihiro,KOHDA Yuka,MIURA Katsuyuki,GEMBA Munekazu
Journal of pharmacological sciences 111(4), 433-439, 2009-12-20
… Cisplatin increased blood urea nitrogen (BUN), plasma creatinine, and elicited glucosuria and enzymuria at 3 days after administration, but these changes were restored to the normal level after 14 days. … Sustained renal fibrosis worsened renal function again at 56 days. …
NAID 10026154860

Multiple bone fracture due to Fanconi's syndrome in primary Sjögren's syndrome complicated with organizing pneumonia.

Nakamura Hideki,Kita Junko,Kawakami Atsushi,Yamasaki Satoshi,Ida Hiroaki,Sakamoto Noriho,Furusu Akira,Eguchi Katsumi
Rheumatology international 30(2), 265-267, 2009-12
… A 66-year-old woman showing renal dysfunction with elevated serum alkaline phosphatase and anti-SS-A antibody was admitted. … Fanconi's syndrome was diagnosed by renal tubular acidosis along with renal glucosuria or aminoaciduria and multiple bone fractures on bone scintigraphy. …
NAID 120001629865

バルプロ酸による Fanconi 症候群から急性腎不全を呈した難治性てんかんの1例

田中幸代,鈴川純子,荒木敦,今井雄一郎,高屋淳二,谷内昇一郎,蓮井正史,金子一成
日本小児腎臓病学会雑誌 = Japanese journal of pediatric nephrology 21(2), 182-187, 2008-11-15
　バルプロ酸 (valproate: VPA) によるFanconi症候群 (以下，本症) を呈していた22歳の重症心身障害者が，肺炎を契機に急性腎不全を合併した。本症に急性腎不全を合併した報告は，検索した範囲では見あたらなかった。　患者は生後8ヵ月からWest症候群の治療としてVPAを投与されており，定期的な血液，尿検査を受けていたが，21歳7ヵ月から低尿酸血症を，21歳9ヵ月から尿糖・蛋白尿を …
NAID 10025170507

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関連記事	「renal」「glucosuria」

「renal」

Renal glycosuria
	Glucose
Classification and external resources
Specialty	endocrinology
ICD-10	E74.8
ICD-9-CM	271.4
OMIM	233100
DiseasesDB	29130
eMedicine	ped/1991
MeSH	D006030