- 同
- Treg
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- any of various controls or devices for regulating or controlling fluid flow, pressure, temperature, etc.
- an official responsible for control and supervision of a particular activity or area of public interest
- the 20th letter of the Roman alphabet (同)t
- a tough youth of 1950s and 1960s wearing Edwardian style clothes (同)Teddy boy
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 取り締まり人;調整者 / 調整装置
- tritiumの化学記号
UpToDate Contents
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- 1. ヘルパーT細胞サブセット：疾患における分化および役割 t helper subsets differentiation and role in disease
- 2. 移植片対宿主病の病因 pathogenesis of graft versus host disease
- 3. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
- 4. 適応細胞性免疫応答 the adaptive cellular immune response
- 5. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
English Journal
- Alteration in Frequency and Function of CD4+CD25+FOXP3+ Regulatory T cells in Patients with Immune Thrombocytopenic Purpura.
- Arandi N, Mirshafiey A, Jeddi-Tehrani M, Shaghaghi M, Sadeghi B, Abolhassani H, Sharifian RA, Rahiminejad MS, Aghamohammadi A.Author information Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. nargess_786@yahoo.com.AbstractImmune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder characterized by production of auto-antibodies against platelet antigens. It is obvious that regulatory T cells (Tregs) have a major role in controlling immune homeostasis and preventing autoimmunity.To investigate the frequency and functions of Tregs, twenty ITP patients and twenty age- and sex-matched healthy controls were recruited. The peripheral blood mononuclear cells were isolated and the proportion of Tregs was defined by flow cytometry method. The expression of immune-regulatory markers, cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and glucocorticoid induced tumor necrosis factor receptor (GITR) were also assessed by quantitative Real-time PCR TaqMan method. For evaluation of Treg function, Tregs were enriched and their ability to inhibit proliferation of T cells was measured and levels of immune-regulatory cytokines IL-10 and TGF-β were also measured.Results showed that the frequency of Tregs and the mean fluorescence intensity of FOXP3 protein significantly decreased in ITP patients compared to those in healthy controls. In addition, there was a significant reduction in relative expression of both CTLA-4 and GITR mRNA in ITP patients (P=0.02 and P=0.006, respectively). The suppressive function of Tregs also diminished in ITP patients compared to that in controls. Both IL-10 and TGF-β cytokines were produced in lower amounts in ITP patients than controls.It could be concluded that alteration in Treg frequency and functional characteristics might be responsible for loss of self-tolerance and subsequently destructive immune responses observed in ITP patients.
- Iranian journal of allergy, asthma, and immunology.Iran J Allergy Asthma Immunol.2014 Apr;13(2):85-92.
- Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder characterized by production of auto-antibodies against platelet antigens. It is obvious that regulatory T cells (Tregs) have a major role in controlling immune homeostasis and preventing autoimmunity.To investigate the frequenc
- PMID 24338252
- Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared with their peripheral counterparts.
- Maenhout SK, Van Lint S, Emeagi PU, Thielemans K, Aerts JL.Author information Department of Immunology-Physiology, Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Jette, Belgium.AbstractAlthough the main site of action for myeloid-derived suppressor cells (MDSCs) is most likely the tumor microenvironment, so far the study of these cells has been largely restricted to spleen-derived MDSCs. In this study, we compared the suppressive capacity of splenic and tumor-derived MDSCs in different subcutaneous mouse tumor models. We investigated which suppressive mechanisms were involved. Finally, we investigated whether MDSCs and regulatory T cells (Treg ) cooperate in the suppression of T-cell responses. In all models, splenic granulocytic MDSCs (grMDSC) strongly suppress CD4(+) T-cell proliferation while the suppressive effect on CD8(+) T cells is less pronounced. Splenic monocytic MDSCs (moMDSC) have a lower suppressive capacity, compared to grMDSC, on both CD4(+) and CD8(+) T-cell proliferation. Both grMDSC and moMDSC isolated from the tumor have a much stronger suppressive activity compared to MDSCs isolated from the spleen of tumor-bearing mice, associated with a higher NO2 (-) production by the tumor-derived moMDSC and arginase activity for both subsets. The expression of CD80 is also elevated on tumor-derived grMDSC compared with their peripheral counterparts. Direct contact with tumor cells is required for the upregulation of CD80 and CD80(+) MDSCs are more suppressive than CD80(-) MDSCs. Coculture of Treg and MDSCs leads to a stronger suppression of CD8(+) T-cell proliferation compared to the suppression observed by Treg or MDSCs alone. Thus, we showed that tumor-infiltrating MDSCs possess a stronger suppressive capacity than their peripheral counterparts and that various suppressive mechanisms account for this difference.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 1;134(5):1077-90. doi: 10.1002/ijc.28449. Epub 2013 Sep 23.
- Although the main site of action for myeloid-derived suppressor cells (MDSCs) is most likely the tumor microenvironment, so far the study of these cells has been largely restricted to spleen-derived MDSCs. In this study, we compared the suppressive capacity of splenic and tumor-derived MDSCs in diff
- PMID 23983191
- T cells from autoimmune patients display reduced sensitivity to immunoregulation by mesenchymal stem cells: Role of IL-2.
- Ben-Ami E, Miller A, Berrih-Aknin S.Author information Rappaport Faculty of Medicine, Technion, Haifa, Israel.AbstractMesenchymal stem cells (MSCs) are multipotent progenitor cells which have been shown to possess broad immunoregulatory and anti-inflammatory capabilities, making them a promising tool to treat autoimmune diseases (AIDs). Nevertheless, as in recent years T cells from AID patients have been found to resist suppression by regulatory T cells, the question of whether they could be regulated by MSCs arises. To use MSCs as a therapeutic tool in human autoimmune diseases, one prerequisite is that T cells from autoimmune patients will be sensitive to these stem cells. The aim of this work was to investigate the ability of healthy donor derived MSCs to inhibit the proliferation of T cells from two pathophysiologically different AIDs: Multiple Sclerosis (MS) and Myasthenia Gravis (MG). We show that MSC-induced inhibition of interferon-γ production and surface expression of the CD3, CD4 and CD28 receptors by activated lymphocytes was similar in the AID patients and healthy controls. Contrarily, the MSCs' ability to suppress the proliferation of T cells of both diseases was significantly weaker compared to their ability to affect T cells of healthy individuals. Although we found that the inhibitory mechanism is mediated through CD14+ monocytes, the faulty cellular component is the patients' T cells. MSC-treated MS and MG lymphocytes were shown to produce significantly more IL-2 than healthy subjects while coupling of the MSC treatment with neutralizing IL-2 antibodies resulted in inhibition levels similar to those of the healthy controls. MSCs were also found to down-regulate the lymphocyte surface expression of the IL-2 receptor (CD25) through both transcription inhibition and induction of receptor shedding. Addition of IL-2 to MSC-inhibited lymphocytes restored proliferation thus suggesting a key role played by this cytokine in the inhibitory mechanism. Taken together, these results demonstrate the potential of a MSC-based cellular therapy for MS, MG and possibly other autoimmune diseases but also highlight the need for a better understanding of the underlying mechanisms for development and optimization of clinical protocols.
- Autoimmunity reviews.Autoimmun Rev.2014 Feb;13(2):187-96. doi: 10.1016/j.autrev.2013.09.007. Epub 2013 Oct 11.
- Mesenchymal stem cells (MSCs) are multipotent progenitor cells which have been shown to possess broad immunoregulatory and anti-inflammatory capabilities, making them a promising tool to treat autoimmune diseases (AIDs). Nevertheless, as in recent years T cells from AID patients have been found to r
- PMID 24121085
Japanese Journal
- ビフィドバクテリウムによるTr1細胞の誘導 (特集 共生菌と免疫)
- 香山 尚子,竹田 潔
- 臨床免疫・アレルギー科 62(2), 134-139, 2014-08
- NAID 40020184822
- 腸管関連リンパ組織におけるストローマ細胞の役割 (特集 組織における免疫応答の特性)
- 八村 敏志
- 臨床免疫・アレルギー科 62(1), 14-16, 2014-07
- NAID 40020155195
- Minor contribution of cytotoxic T lymphocyte antigen 4 and programmed cell death 1 ligand 1 in immune tolerance against mouse thyrotropin receptor in mice
- Yasui Junichi,Nakahara Mami,Shimamura Mika,Kurashige Tomomi,Yasui Kazuaki,Abiru Norio,Kawakami Atsushi,Nagayama Yuji
- Acta medica Nagasakiensia 59(1), 13-17, 2014-07
- … We here explored the contribution of a peripheral arm of immune tolerance against the mTSHR by using antibodies to deplete regulatory T cells (Tregs), to antagonize co-inhibitory molecules and/or to stimulate co-stimulatory molecules. … Antagonistic anti-co-inhibitory molecules, cytotoxic T lymphocyte antigen 4 (CTLA4) and programmed cell death 1 ligand 1 (PDL1), induced only low levels of anti-TSHR antibodies without induction of hyperthyroidism in a mouse Graves'model. …
- NAID 120005468237
Related Links
- Learn about the immune system regulatory cell, the T Regulator Cell (Treg). ... Regulators of the Immune System Regulatory T cells (Tregs) are critical to the maintenance of immune cell homeostasis as evidenced by the ...
- Regulatory T Cells For many years, different laboratories — usually using different protocols — have found evidence of lymphocytes that suppress immune responses: antibody-mediated and/or cell-mediated. But these cells have been ...
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★リンクテーブル★
| リンク元 | 「制御性T細胞」 |
| 関連記事 | 「regulatory」「T」「regulator」「cell」 |
「制御性T細胞」
- 英
- regulatory T-cell, regulatory T cell, regulatory T-cells, T regulatory cells
- 同
- 調節性T細胞, Treg
- 関
- 自己寛容
「regulatory」
- adj.
- 制御の、調節性の、制御的な、(法律)規制の
「T」
「regulator」
- n.